| Modified iPOND revealed the role of mutant p53 in promoting helicase function and telomere maintenance. | Modified iPOND revealed the role of mutant p53 in promoting helicase function and telomere maintenance.
Wang Q, Hou K, Yang J, Li H, Li C, Zhang Y, Tian J, Li C, Guo B, Jia S, Luo Y., Free PMC Article | 10/24/2023 |
| EPS15-NTRK1: a novel NTRK1 oncogenic fusion in patient with lung adenocarcinoma. | EPS15-NTRK1: a novel NTRK1 oncogenic fusion in patient with lung adenocarcinoma.
Yang S, Li L, Chen D, Xiao M, Xian L. | 07/31/2021 |
| Fcho1/2Eps15/RAP-2 ternary complexes to facilitate conformational activation of AP-2 by the Fcho1/2 interdomain linker to promote AP-2 cargo engagement. | Transient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding.
Ma L, Umasankar PK, Wrobel AG, Lymar A, McCoy AJ, Holkar SS, Jha A, Pradhan-Sundd T, Watkins SC, Owen DJ, Traub LM., Free PMC Article | 06/24/2017 |
| An interaction of Eps15 and pS227-FIP2 at the appropriate time and location in polarizing cells is necessary for proper establishment of epithelial polarity. | Interaction of phosphorylated Rab11-FIP2 with Eps15 regulates apical junction composition.
Lapierre LA, Manning EH, Mitchell KM, Caldwell CM, Goldenring JR., Free PMC Article | 06/3/2017 |
| RAB11FIP3 combines with Eps15 homology domain 1 to promote the endocytosis recycling of phosphorylation of epithelial growth factor receptor. | Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate breast cancer progression via promoting epithelial growth factor receptor recycling.
Tong D, Liang YN, Stepanova AA, Liu Y, Li X, Wang L, Zhang F, Vasilyeva NV. | 03/4/2017 |
| Together, the data indicate that a CUL3-SPOPL E3 ubiquitin ligase complex regulates endocytic trafficking and formation of multivesicular bodies by ubiquitinating and degrading EPS15 at endosomes. | A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes.
Gschweitl M, Ulbricht A, Barnes CA, Enchev RI, Stoffel-Studer I, Meyer-Schaller N, Huotari J, Yamauchi Y, Greber UF, Helenius A, Peter M., Free PMC Article | 12/24/2016 |
| identify USP9X as a novel regulator of EGFR endocytosis | USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15.
Savio MG, Wollscheid N, Cavallaro E, Algisi V, Di Fiore PP, Sigismund S, Maspero E, Polo S. | 12/17/2016 |
| over-expression of EPS15 is a potential favorable prognostic marker in breast cancer. | Over-expression of EPS15 is a favorable prognostic factor in breast cancer.
Dai X, Liu Z, Zhang S. | 08/6/2016 |
| MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins are associated with acute lymphoblastic leukemia. | Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins with acute lymphoblastic leukemia.
Kotecha RS, Ford J, Beesley AH, Anderson D, Cole CH, Kees UR., Free PMC Article | 04/18/2015 |
| Ubiquitin is sufficient for Eps15 recruitment to endosomes. | UIM domain-dependent recruitment of the endocytic adaptor protein Eps15 to ubiquitin-enriched endosomes.
Gucwa AL, Brown DA., Free PMC Article | 01/24/2015 |
| Results indicate that phosphorylation of epidermal growth factor receptor pathway substrate 15 (Eps15) at Ser-796 is catalyzed by p38 directly. | p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.
Zhou Y, Tanaka T, Sugiyama N, Yokoyama S, Kawasaki Y, Sakuma T, Ishihama Y, Saiki I, Sakurai H. | 03/1/2014 |
| distinct forms of Eps15 direct EGFR to either the late endosome/lysosome for degradation (Eps15) or to the recycling endosome for transit back to the cell surface (Eps15S) | Recycling of the epidermal growth factor receptor is mediated by a novel form of the clathrin adaptor protein Eps15.
Chi S, Cao H, Wang Y, McNiven MA., Free PMC Article | 12/10/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC., Free PMC Article | 09/15/2010 |
| analysis of the selective interaction of C-terminal Eps15 homology domain proteins with specific Asn-Pro-Phe-containing partners | Mechanism for the selective interaction of C-terminal Eps15 homology domain proteins with specific Asn-Pro-Phe-containing partners.
Kieken F, Sharma M, Jovic M, Giridharan SS, Naslavsky N, Caplan S, Sorgen PL., Free PMC Article | 04/19/2010 |
| parkin Ubld uses differential surfaces to recruit UIM regions from the S5a proteasomal subunit compared with Eps15 involved in cell signaling. | Differential interaction of the E3 ligase parkin with the proteasomal subunit S5a and the endocytic protein Eps15.
Safadi SS, Shaw GS., Free PMC Article | 02/1/2010 |
| These results indicate that Eps15b is an endosomally localized isoform of Eps15 that is present in the Hrs complex via direct Hrs interaction and important for the sorting function of this complex. | An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor.
Roxrud I, Raiborg C, Pedersen NM, Stang E, Stenmark H., Free PMC Article | 01/21/2010 |
| Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase. | Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase.
Parachoniak CA, Park M., Free PMC Article | 01/21/2010 |
| EPS15 and EPS15R mediated internalization of activated EGF receptor to result in receptor recycling as to reinforce the proliferative response to EGF. | EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
Niehof M, Borlak J. | 01/21/2010 |
| SGIP1alpha plays an essential role in clathrin-mediated endocytosis by interacting with phospholipids and Eps15. | SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15.
Uezu A, Horiuchi A, Kanda K, Kikuchi N, Umeda K, Tsujita K, Suetsugu S, Araki N, Yamamoto H, Takenawa T, Nakanishi H. | 01/21/2010 |
| Eps15 regulates clathrin coat assembly in vivo, and interactions between Eps15 homology domains and NPF motifs are involved in clathrin-coated vesicle formation during synaptic vesicle recycling | Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling.
Morgan JR, Prasad K, Jin S, Augustine GJ, Lafer EM. | 01/21/2010 |
| Data show that the first ubiquitin-interacting motif of Eps15 (UIM1) interacts directly with the UBL domain of ubiquilin, whereas it does not bind to ubiquitinated proteins. | Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.
Regan-Klapisz E, Sorokina I, Voortman J, de Keizer P, Roovers RC, Verheesen P, Urbé S, Fallon L, Fon EA, Verkleij A, Benmerah A, van Bergen en Henegouwen PM. | 01/21/2010 |
| However, GFP-EH21 (a mutant Eps15) expression caused a 50% reduction in released enveloped virions, decreased formation of satellite plaques, and delayed virus spread, indicating an important role for receptor-mediated endocytosis. | Role of receptor-mediated endocytosis in the formation of vaccinia virus extracellular enveloped particles.
Husain M, Moss B., Free PMC Article | 01/21/2010 |
| JC virus binding to human glial cells induces an intracellular signal that is critical for entry and infection by a ligand-inducible clathrin and eps15-dependent mechanism. | A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway.
Querbes W, Benmerah A, Tosoni D, Di Fiore PP, Atwood WJ., Free PMC Article | 01/21/2010 |
| Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome. | The Troyer syndrome (SPG20) protein spartin interacts with Eps15.
Bakowska JC, Jenkins R, Pendleton J, Blackstone C. | 01/21/2010 |