| PRG2 and AQPEP are misexpressed in fetal membranes in placenta previa and percretadagger. | PRG2 and AQPEP are misexpressed in fetal membranes in placenta previa and percreta†.
Zhang ET, Hannibal RL, Badillo Rivera KM, Song JHT, McGowan K, Zhu X, Meinhardt G, Knöfler M, Pollheimer J, Urban AE, Folkins AK, Lyell DJ, Baker JC., Free PMC Article | 12/25/2021 |
| Overexpression of LVRN impedes the invasion of trophoblasts by inhibiting epithelial-mesenchymal transition. | Overexpression of LVRN impedes the invasion of trophoblasts by inhibiting epithelial-mesenchymal transition.
Feng X, Wei Z, Zhang S, Zhou J, Wu J, Luan B, Du Y, Zhao H. | 06/12/2021 |
| First trimester maternal serum laeverin level cannot be used to predict preeclampsia. | Maternal serum laeverin (aminopeptidase Q) measured in the first trimester of pregnancy does not predict preeclampsia.
Pihl K, Sørensen S, Nystad M, Acharya G, Jørgensen FS. | 01/25/2020 |
| Laeverin is expressed in all trophoblast cell types of normal and preeclamptic placentas. Expression pattern of laeverin in trophoblast cells is heterogeneous and not necessarily membrane-bound. | Laeverin protein expression in normal and preeclamptic placentas using tissue microarray analysis.
Nystad M, Sitras V, Nordbakken CV, Pedersen MI, Acharya G. | 11/3/2018 |
| In preeclamptic placentas, laeverin is experssed in the cytoplasm and microvesicles, rather than the cell membrane. Laeverin appears to be involved in trophoblast cell migration and invasion through interaction with integrins and matrix metalloprotease 1. | Placental expression of aminopeptidase-Q (laeverin) and its role in the pathophysiology of preeclampsia.
Nystad M, Sitras V, Larsen M, Acharya G. | 01/31/2015 |
| Laeverin is a specific cell-surface marker for human extravillous trophoblast (EVT) and plays a regulatory role in EVT migration. | Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation.
Horie A, Fujiwara H, Sato Y, Suginami K, Matsumoto H, Maruyama M, Konishi I, Hattori A. | 02/2/2013 |
| Replacement of glutamine-238 with alanine caused a significant change in substrate specificity rather than a decrease in enzymatic activity. | Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q.
Goto Y, Yoshioka R, Arisaka N, Hattori A, Tsujimoto M. | 05/21/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| These results indicate that His(379) of laeverin plays essential roles in its distinctive enzymatic properties and contributes to maintaining the appropriate structure of the catalytic cavity of the enzyme. | Histidine 379 of human laeverin/aminopeptidase Q, a nonconserved residue within the exopeptidase motif, defines its distinctive enzymatic properties.
Maruyama M, Arisaka N, Goto Y, Ohsawa Y, Inoue H, Fujiwara H, Hattori A, Tsujimoto M., Free PMC Article | 02/8/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.
Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK., Free PMC Article | 08/12/2009 |
| is a novel bestatin-sensitive leucine aminopeptidase; plays important roles in human placentation by regulating biological activity of key peptides at the embryo-maternal interface | Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases.
Maruyama M, Hattori A, Goto Y, Ueda M, Maeda M, Fujiwara H, Tsujimoto M. | 01/21/2010 |
| The 3 most significantly overexpressed genes in rheumatoid arthritis were laeverin, 11beta-hydroxysteroid dehydrogenase type 2 (a steroid pathway enzyme), and cysteine-rich, angiogenic inducer 61 (a known angiogenic factor). | Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins.
Haas CS, Creighton CJ, Pi X, Maine I, Koch AE, Haines GK, Ling S, Chinnaiyan AM, Holoshitz J. | 01/21/2010 |
| A novel membrane-bound cell surface peptidase, laeverin (FLJ90650), was found to be specifically expressed on extravillous trophoblasts that had almost ceased invasion into maternal decidual tissues. | Regulation of human extravillous trophoblast function by membrane-bound peptidases.
Fujiwara H, Higuchi T, Sato Y, Nishioka Y, Zeng BX, Yoshioka S, Tatsumi K, Ueda M, Maeda M. | 01/17/2006 |
| Extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases(laeverin) | Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases.
Fujiwara H, Higuchi T, Yamada S, Hirano T, Sato Y, Nishioka Y, Yoshioka S, Tatsumi K, Ueda M, Maeda M, Fujii S. | 01/21/2010 |