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    ERBB4 erb-b2 receptor tyrosine kinase 4 [ Homo sapiens (human) ]

    Gene ID: 2066, updated on 12-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    HER4 is a high-affinity dimerization partner for all EGFR/HER/ErbB family proteins.

    HER4 is a high-affinity dimerization partner for all EGFR/HER/ErbB family proteins.
    Singh PK, Kim S, Smith AW.,

    11/7/2024
    The role and mechanism of NRG1/ErbB4 in inducing the differentiation of induced pluripotent stem cells into cardiomyocytes.

    The role and mechanism of NRG1/ErbB4 in inducing the differentiation of induced pluripotent stem cells into cardiomyocytes.
    Li X, Zhang H, Li W, Tuo H, He B, Jiang H., Free PMC Article

    10/20/2024
    Unraveling the Genetic Associations of DENND1A (rs9696009) and ERBB4 (rs2178575) with Infertile Polycystic Ovary Syndrome Females in Pakistan.

    Unraveling the Genetic Associations of DENND1A (rs9696009) and ERBB4 (rs2178575) with Infertile Polycystic Ovary Syndrome Females in Pakistan.
    Samma ZH, Khan HN, Riffat S, Ashraf M, Rehman R.

    07/5/2024
    Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer.

    Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer.
    Adashek JJ, Pandya C, Maragakis NJ, De P, Cohen PR, Kato S, Kurzrock R., Free PMC Article

    03/21/2024
    ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression.

    ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression.
    Tang R, Cui H, Dou R, Tao L, Tan L, Guo T, Luo D.

    01/5/2024
    Genetic variants of ERBB4 gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study.

    Genetic variants of ERBB4 gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study.
    Li R, Wang Y, Yang L, Zhong P, Huang G, Liang Q, Yu X., Free PMC Article

    01/4/2024
    MicroRNA-23a-3p Is Upregulated in Plasma Exosomes of Bulbar-onset ALS Patients and Targets ERBB4.

    MicroRNA-23a-3p Is Upregulated in Plasma Exosomes of Bulbar-onset ALS Patients and Targets ERBB4.
    Liu Y, Ding M, Pan S, Zhou R, Yao J, Fu R, Yu H, Lu Z.

    07/26/2023
    NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders.

    NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders.
    Vulf M, Bograya M, Komar A, Khaziakhmatova O, Malashchenko V, Yurova K, Sirotkina A, Minchenko A, Kirienkova E, Gazatova N, Litvinova L.

    06/30/2023
    miR-433 Inhibits Glioblastoma Progression by Suppressing the PI3K/Akt Signaling Pathway Through Direct Targeting of ERBB4.

    miR-433 Inhibits Glioblastoma Progression by Suppressing the PI3K/Akt Signaling Pathway Through Direct Targeting of ERBB4.
    Jiang H, Su Z, Hu W, Yuan X, Yu T, Yang J, Xiao X, Zheng S, Lin B.

    06/7/2023
    Genetic interaction between GABRA1 and ERBB4 variants in the pathogenesis of genetic generalized epilepsy.

    Genetic interaction between GABRA1 and ERBB4 variants in the pathogenesis of genetic generalized epilepsy.
    Chan CK, Lim KS, Low SK, Tan CT, Ng CC.

    02/4/2023
    Cancer regulator EGFR-ErbB4 heterodimer is stabilized through glycans at the dimeric interface.

    Cancer regulator EGFR-ErbB4 heterodimer is stabilized through glycans at the dimeric interface.
    Motamedi Z, Shahsavari M, Rajabi-Maham H, Azimzadeh Irani M.

    12/24/2022
    The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity.

    The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity.
    Latorre J, Martínez C, Ortega F, Oliveras-Cañellas N, Díaz-Sáez F, Aragonés J, Camps M, Gumà A, Ricart W, Fernández-Real JM, Moreno-Navarrete JM.

    12/3/2022
    Neuregulin-1 regulates the conversion of M1/M2 microglia phenotype via ErbB4-dependent inhibition of the NF-kappaB pathway.

    Neuregulin-1 regulates the conversion of M1/M2 microglia phenotype via ErbB4-dependent inhibition of the NF-κB pathway.
    Ma Y, Fan P, Zhao R, Zhang Y, Wang X, Cui W.

    06/18/2022
    Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3.

    Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3.
    Ahmad T, Vullhorst D, Chaudhuri R, Guardia CM, Chaudhary N, Karavanova I, Bonifacino JS, Buonanno A., Free PMC Article

    05/21/2022
    Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281.

    Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281.
    Wang J, Li J, Duan P, Dang Y, Shi T.

    04/23/2022
    miR-551b is Associated with the Poor Prognosis and Malignant Development of Papillary Thyroid Cancer Through Regulating ERBB4.

    miR-551b is Associated with the Poor Prognosis and Malignant Development of Papillary Thyroid Cancer Through Regulating ERBB4.
    Wang J, Liu H.

    04/16/2022
    miR-93-5p knockdown repressed hepatocellular carcinoma progression via increasing ERBB4 and TETs-dependent DNA demethylation.

    miR-93-5p knockdown repressed hepatocellular carcinoma progression via increasing ERBB4 and TETs-dependent DNA demethylation.
    Li Y, Wu B, Sun R, Zhao M, Li N.

    04/2/2022
    ERBB4 exonic deletions on chromosome 2q34 in patients with intellectual disability or epilepsy.

    ERBB4 exonic deletions on chromosome 2q34 in patients with intellectual disability or epilepsy.
    Hyder Z, Van Paesschen W, Sabir A, Sansbury FH, Burke KB, Khan N, Chandler KE, Cooper NS, Wright R, McHale E, Van Esch H, Banka S., Free PMC Article

    03/26/2022
    ErbB4-mediated regulation of vasculogenic mimicry capability in breast cancer cells.

    ErbB4-mediated regulation of vasculogenic mimicry capability in breast cancer cells.
    Kawahara R, Simizu S., Free PMC Article

    03/12/2022
    The role of ERBB4 mutations in the prognosis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors.

    The role of ERBB4 mutations in the prognosis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors.
    Hu X, Xu H, Xue Q, Wen R, Jiao W, Tian K., Free PMC Article

    02/26/2022
    Genetic association study of ERBB4 SNP rs1351592 with polycystic ovary syndrome in Pakistani population.

    Genetic association study of ERBB4 SNP rs1351592 with polycystic ovary syndrome in Pakistani population.
    Afzal T, Raja GK, Afzal M, Ahmad S, Sultana N, Kalsoom UE.

    02/19/2022
    A Review of HER4 (ErbB4) Kinase, Its Impact on Cancer, and Its Inhibitors.

    A Review of HER4 (ErbB4) Kinase, Its Impact on Cancer, and Its Inhibitors.
    El-Gamal MI, Mewafi NH, Abdelmotteleb NE, Emara MA, Tarazi H, Sbenati RM, Madkour MM, Zaraei SO, Shahin AI, Anbar HS., Free PMC Article

    02/12/2022
    MiR-193b-3p-ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes.

    MiR-193b-3p-ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes.
    Huang C, Zhong W, Ren X, Huang X, Li Z, Chen C, Jiang B, Chen Z, Jian X, Yang L, Liu X, Huang H, Shen C, Chen X, Dou X, Yu B., Free PMC Article

    02/5/2022
    miR-323a regulates ERBB4 and is involved in depression.

    miR-323a regulates ERBB4 and is involved in depression.
    Fiori LM, Kos A, Lin R, Théroux JF, Lopez JP, Kühne C, Eggert C, Holzapfel M, Huettl RE, Mechawar N, Belzung C, Ibrahim EC, Chen A, Turecki G.

    01/29/2022
    Association of NRG3 and ERBB4 gene polymorphism with nicotine dependence in Turkish population.

    Association of NRG3 and ERBB4 gene polymorphism with nicotine dependence in Turkish population.
    Kara HG, Erdal ME, Yılmaz SG, Şengül C, Şengül CB, Karakülah K.

    01/22/2022
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