| Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma. | Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma.
Xu S, Wang H, Zhu Y, Han Y, Liu L, Zhang X, Hu J, Zhang W, Duan S, Deng J, Zhang Z, Liu S., Free PMC Article | 07/5/2024 |
| The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex. | The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex.
Cubillos P, Ditzer N, Kolodziejczyk A, Schwenk G, Hoffmann J, Schütze TM, Derihaci RP, Birdir C, Köllner JE, Petzold A, Sarov M, Martin U, Long KR, Wimberger P, Albert M., Free PMC Article | 04/24/2024 |
| IGF2BP2 promotes cell invasion and epithelial-mesenchymal transition through Src-mediated upregulation of EREG in oral cancer. | IGF2BP2 promotes cell invasion and epithelial-mesenchymal transition through Src-mediated upregulation of EREG in oral cancer.
Lin CW, Yang WE, Su CW, Lu HJ, Su SC, Yang SF., Free PMC Article | 02/16/2024 |
| MicroRNA-1179 targets Epiregulin (EREG) regulates the proliferation and metastasis of human multiple myeloma cells. | MicroRNA-1179 targets Epiregulin (EREG) regulates the proliferation and metastasis of human multiple myeloma cells.
Liu X, Qin L, Li W, Fei F. | 06/23/2023 |
| Two Cases of Biphasic Synovial Sarcoma With Expression of PAX8 and ER: A Diagnostic Pitfall. | Two Cases of Biphasic Synovial Sarcoma With Expression of PAX8 and ER: A Diagnostic Pitfall.
Zheng L, Wang XI, Chen S, Moosvi AM, Wan DQ, Zhang S. | 05/8/2023 |
| Differentially expressed EREG and SPP1 are independent prognostic markers in cervical squamous cell carcinoma. | Differentially expressed EREG and SPP1 are independent prognostic markers in cervical squamous cell carcinoma.
Zhang L, Nan F, Yang L, Dong Y, Tian Y. | 07/9/2022 |
| Epiregulin increases stemness-associated genes expression and promotes chemoresistance of non-small cell lung cancer via ERK signaling. | Epiregulin increases stemness-associated genes expression and promotes chemoresistance of non-small cell lung cancer via ERK signaling.
Zhang Y, Qiu F, Ye T, Lee SH, Xu J, Jia L, Zeng R, Wang X, Hu X, Yan X, Li H, Lu Y, Wang X, Jiang R, Xu W., Free PMC Article | 05/28/2022 |
| MiR-192-5p suppresses M1 macrophage polarization via epiregulin (EREG) downregulation in gouty arthritis. | MiR-192-5p suppresses M1 macrophage polarization via epiregulin (EREG) downregulation in gouty arthritis.
An L, Yin F. | 03/5/2022 |
| Immunohistochemical evaluation of the prognostic and predictive power of epidermal growth factor receptor ligand levels in patients with metastatic colorectal cancer. | Immunohistochemical evaluation of the prognostic and predictive power of epidermal growth factor receptor ligand levels in patients with metastatic colorectal cancer.
Foroughi S, Hutchinson RA, Wong HL, Christie M, Batrouney A, Wong R, Lee M, Tie J, Burgess AW, Gibbs P. | 01/22/2022 |
| p130Cas Is Correlated with EREG Expression and a Prognostic Factor Depending on Colorectal Cancer Stage and Localization Reducing FOLFIRI Efficacy. | p130Cas Is Correlated with EREG Expression and a Prognostic Factor Depending on Colorectal Cancer Stage and Localization Reducing FOLFIRI Efficacy.
Kumbrink J, Li P, Pók-Udvari A, Klauschen F, Kirchner T, Jung A., Free PMC Article | 12/18/2021 |
| Induction of apically mistrafficked epiregulin disrupts epithelial polarity via aberrant EGFR signaling. | Induction of apically mistrafficked epiregulin disrupts epithelial polarity via aberrant EGFR signaling.
Singh B, Bogatcheva G, Krystofiak E, McKinley ET, Hill S, Rose KL, Higginbotham JN, Coffey RJ., Free PMC Article | 10/30/2021 |
| Possible role of epiregulin from dermal fibroblasts in the keratinocyte hyperproliferation of psoriasis. | Possible role of epiregulin from dermal fibroblasts in the keratinocyte hyperproliferation of psoriasis.
Iwata H, Haga N, Ujiie H. | 09/11/2021 |
| Role of the calcium-sensing receptor (CaSR) in cancer metastasis to bone: Identifying a potential therapeutic target. | Role of the calcium-sensing receptor (CaSR) in cancer metastasis to bone: Identifying a potential therapeutic target.
Tuffour A, Kosiba AA, Zhang Y, Peprah FA, Gu J, Shi H. | 07/24/2021 |
| Depletion of EREG enhances the osteo/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment. | Depletion of EREG enhances the osteo/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment.
Ran R, Yang H, Cao Y, Yan W, Jin L, Zheng Y., Free PMC Article | 07/17/2021 |
| EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy. | EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy.
Liu S, Wang Y, Han Y, Xia W, Zhang L, Xu S, Ju H, Zhang X, Ren G, Liu L, Ye W, Zhang Z, Hu J., Free PMC Article | 06/5/2021 |
| Human papillomavirus-positivity is associated with EREG down-regulation and promoter hypermethylation in head and neck squamous cell carcinoma. | Human papillomavirus-positivity is associated with EREG down-regulation and promoter hypermethylation in head and neck squamous cell carcinoma.
Khanal S, Strickley JD, Ha T, Demehri S, Ghim SJ, Jenson AB, Redman RA, Joh JJ. | 02/6/2021 |
| Platelet-derived growth factor-AA-inducible epiregulin promotes elongation of human hair shafts by enhancing proliferation and differentiation of follicular keratinocytes. | Platelet-derived growth factor-AA-inducible epiregulin promotes elongation of human hair shafts by enhancing proliferation and differentiation of follicular keratinocytes.
Jeong HS, Kwack MH, Joo HW, Kim MK, Kim JC, Sung YK. | 11/28/2020 |
| Epiregulin promotes osteogenic differentiation and inhibits neurogenic trans-differentiation of adipose-derived mesenchymal stem cells via MAPKs pathway. | Epiregulin promotes osteogenic differentiation and inhibits neurogenic trans-differentiation of adipose-derived mesenchymal stem cells via MAPKs pathway.
Cao Y, Shi R, Yang H, Zhang J, Ge L, Gao R, Fan Z. | 11/21/2020 |
| High EREG Expression Is Predictive of Better Outcomes in Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy. | High EREG Expression Is Predictive of Better Outcomes in Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy.
Lin CY, Hsieh PL, Chou CL, Yang CC, Lee SW, Tian YF, Shiue YL, Li WS. | 08/29/2020 |
| E2F7, EREG, miR-451a and miR-106b-5p were likely to be related to the cervical cancer development. | E2F7, EREG, miR-451a and miR-106b-5p are associated with the cervical cancer development.
Zong S, Liu X, Zhou N, Yue Y. | 03/7/2020 |
| results reveal a novel molecular mechanism of resistance to hormone therapies in which the miR-186-3p/EREG axis orchestrates tamoxifen resistance and aerobic glycolysis in estrogen receptor-positive breast cancer | The miR-186-3p/EREG axis orchestrates tamoxifen resistance and aerobic glycolysis in breast cancer cells.
He M, Jin Q, Chen C, Liu Y, Ye X, Jiang Y, Ji F, Qian H, Gan D, Yue S, Zhu W, Chen T. | 02/15/2020 |
| These results indicated that EREG improved the migration and chemotaxis ability of adipose-derived mesenchymal stem cells and depended on the activation of MAPK signaling pathways, including p38 MAPK, JNK, and Erk1/2. | Epiregulin promotes the migration and chemotaxis ability of adipose-derived mesenchymal stem cells via mitogen-activated protein kinase signaling pathways.
Cao Y, Wang L, Yang H, Lin X, Li G, Han N, Du J, Fan Z. | 12/21/2019 |
| High EREG expression in cancer-associated fibroblasts correlated with higher T stage, deeper invasion and inferior worst pattern of invasion (WPOI) in oral squamous cell carcinoma patients and predicted shorter overall survival. Overexpression of EREG in NFs activated the cancer-associated fibroblasts phenotype. | Epiregulin reprograms cancer-associated fibroblasts and facilitates oral squamous cell carcinoma invasion via JAK2-STAT3 pathway.
Wang Y, Jing Y, Ding L, Zhang X, Song Y, Chen S, Zhao X, Huang X, Pu Y, Wang Z, Ni Y, Hu Q., Free PMC Article | 12/14/2019 |
| AREG and EREG mRNA expression levels in left-sided CRC were higher than in right-sided tumors. This may help explain why left-sided CRC is more responsive to anti-EGFR antibodies. | Amphiregulin/epiregulin mRNA Expression and Primary Tumor Location in Colorectal Cancer.
Kuramochi H, Nakajima GO, Hayashi K, Araida T, Yamamoto M. | 09/28/2019 |
| finding demonstrate that EREG is an independent prognostic biomarker for gastric cancer | Elevated epiregulin expression predicts poor prognosis in gastric cancer.
Xia Q, Zhou Y, Yong H, Wang X, Zhao W, Ding G, Zhu J, Li X, Feng Z, Wang B. | 08/31/2019 |