| Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication. | Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication.
Lv M, Yao T, Zhang Y, Ma S, Chen J, Tang Z, Zang G, Chen X. | 05/24/2023 |
| These results combined with mutation analyses allow us to propose a molecular model underlying MHC-I peptide selection by tapasin. | Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.
Hafstrand I, Sayitoglu EC, Apavaloaei A, Josey BJ, Sun R, Han X, Pellegrino S, Ozkazanc D, Potens R, Janssen L, Nilvebrant J, Nygren PÅ, Sandalova T, Springer S, Georgoudaki AM, Duru AD, Achour A., Free PMC Article | 05/11/2019 |
| Qa-1b-restricted CD8+ T cells display characteristics of both conventional hypervariable T cells as well as invariant T cells and can be classified as semi-invariant T cells, with only conserved Valpha usage, positioned between these two known T cell subsets. | T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1(b) with TAP-Independent Peptides Are Semi-Invariant Lymphocytes.
Doorduijn EM, Sluijter M, Querido BJ, Seidel UJE, Oliveira CC, van der Burg SH, van Hall T., Free PMC Article | 03/2/2019 |
| Absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. Tpn defined the characteristic carboxy termini of canonical MHC I peptides. | ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.
Kanaseki T, Lind KC, Escobar H, Nagarajan N, Reyes-Vargas E, Rudd B, Rockwood AL, Van Kaer L, Sato N, Delgado JC, Shastri N., Free PMC Article | 03/22/2014 |
| modification of Tapasin can enhance the presentation of targeting antigens via intracellular delivery to DCs and elicit specific CTL immune responses efficiently | The modification of Tapasin enhances cytotoxic T lymphocyte activity of intracellularly delivered CTL epitopes via cytoplasmic transduction peptide.
Chen X, Liu H, Tang Z, Yu Y, Zang G. | 09/14/2013 |
| Data show that tapasin expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms. | Impact of beta 2-microglobulin on tapasin expression and covalent association.
Simone LC, Smith BL, Solheim JC., Free PMC Article | 04/6/2013 |
| Deletion of a loop within the tapasin C-terminal Ig-like domain (Delta334-342) prevented tapasin association with the MHC class I molecule K(d). | Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.
Simone LC, Georgesen CJ, Simone PD, Wang X, Solheim JC., Free PMC Article | 05/12/2012 |
| E2F1 is an essential transcription factor for tapasin. | Identification of E2F1 as an important transcription factor for the regulation of tapasin expression.
Bukur J, Herrmann F, Handke D, Recktenwald C, Seliger B., Free PMC Article | 10/30/2010 |
| showed that a large disulfide-bonded complex was present in the mouse cells that included ERp57, tapasin, and K(d). | Effect of a tapasin mutant on the assembly of the mouse MHC class I molecule H2-K(d).
Simone LC, Wang X, Tuli A, Solheim JC., Free PMC Article | 01/25/2010 |
| Tapasin editing is a contributing factor to the phenomenon of immunodominance. | Absence of tapasin alters immunodominance against a lymphocytic choriomeningitis virus polytope.
Boulanger DS, Oliveira R, Ayers L, Prior SH, James E, Williams AP, Elliott T. | 01/21/2010 |
| the free cysteine 95 in mouse tapasin influences stable expression at the plasma membrane for both MHC class I allotypes, and have shown that tapasin's interaction with folded K(d) is elevated by the C95S substitution in tapasin. | Comparative analysis of the impact of a free cysteine in tapasin on the maturation and surface expression of murine MHC class I allotypes.
Wang X, Simone LC, Tuli A, Solheim JC., Free PMC Article | 01/21/2010 |
| A K408W mutation in the transmembrane/cytoplasmic domain disrupted K(d) folding & release from tapasin, but not interaction with TAP. The C terminus plays a role in enabling class I molecules to be expressed at the surface of mouse cells. | Influence of the tapasin C terminus on the assembly of MHC class I allotypes.
Simone LC, Wang X, Tuli A, McIlhaney MM, Solheim JC., Free PMC Article | 01/21/2010 |
| Mutational analysis of tapasin provides insight into aspects of tapasin structure that are crucial to its ability to assist major histocompatibility complex class I assembly. | The Ig-like domain of tapasin influences intermolecular interactions.
Turnquist HR, Petersen JL, Vargas SE, McIlhaney MM, Bedows E, Mayer WE, Grandea AG 3rd, Van Kaer L, Solheim JC. | 01/21/2010 |
| Data show that cell surface expression of TAP-independent class I complexes is modulated by tapasin levels and is enhanced by interferon-gamma. | Assembly and cell surface expression of TAP-independent, chloroquine-sensitive and interferon-gamma-inducible class I MHC complexes in transformed fibroblast cell lines are regulated by tapasin.
Fromm SV, Duady-Ben Yaakov S, Schechter C, Ehrlich R. | 01/21/2010 |
| Essential for stable expression of the antigen-processing transmembrane domain of the TAP2 protein. | Multiple residues in the transmembrane helix and connecting peptide of mouse tapasin stabilize the transporter associated with the antigen-processing TAP2 subunit.
Papadopoulos M, Momburg F. | 01/21/2010 |
| Mouse tapasin has quantitative and qualitative effects on the HLA-B*2705-bound peptide repertoire, impairing presentation of some suitable ligands and allowing others with suboptimal anchor residues and lower affinity to be presented. | Qualitative and quantitative differences in peptides bound to HLA-B27 in the presence of mouse versus human tapasin define a role for tapasin as a size-dependent peptide editor.
Sesma L, Galocha B, Vázquez M, Purcell AW, Marcilla M, McCluskey J, López de Castro JA. | 01/21/2010 |
| demonstrate a key role for tapasin in shaping the MHC class I peptide repertoire, as enhancement of presentation in the presence of tapasin correlated with peptide half-life. | Tapasin enhances MHC class I peptide presentation according to peptide half-life.
Howarth M, Williams A, Tolstrup AB, Elliott T., Free PMC Article | 01/21/2010 |
| Tapasin links class Ib molecule Qa-1b to the transporter associated with antigen processing (TAP) peptide and facilitates the delivery of Qa-1b to the cell surface. | Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs.
Li L, Sullivan BA, Aldrich CJ, Soloski MJ, Forman J, Grandea AG 3rd, Jensen PE, Van Kaer L. | 01/21/2010 |
| tapasin has a essential function of tapasin in quality control of HLA-G molecules | An essential function of tapasin in quality control of HLA-G molecules.
Park B, Ahn K. | 01/21/2010 |
| A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression. | A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression.
Garbi N, Tiwari N, Momburg F, Hämmerling GJ. | 01/21/2010 |
| Role of tapasin in MHC class I antigen presentation in vivo. | Role of tapasin in MHC class I antigen presentation in vivo.
Garbi N, Tan P, Momburg F, Hämmerling GJ. | 01/21/2010 |
| Tapasin is required for class I major histocompatibility complex (MHC-I) to bind endoplasmic reticulum-derived stabilizing peptides to achieve stability needed for alternate MHC-I processing via peptide exchange in acidic vacuolar processing compartments. | Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH.
Chefalo PJ, Grandea AG 3rd, Van Kaer L, Harding CV. | 01/21/2010 |
| Tapasin is critical for loading of N-formylated peptides onto the intracellular pool of H2-M3 during the assembly of M3-peptide complexes in the endoplasmic reticulum. | Functional roles of TAP and tapasin in the assembly of M3-N-formylated peptide complexes.
Chun T, Grandea AG 3rd, Lybarger L, Forman J, Van Kaer L, Wang CR. | 10/16/2001 |
| During the assembly of H2-M3, tapasin directly facilitates intracellular peptide binding but is not required for intracellular retention of open conformers. | Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers.
Lybarger L, Yu YY, Chun T, Wang CR, Grandea AG 3rd, Van Kaer L, Hansen TH. | 10/30/2001 |