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    F2R coagulation factor II thrombin receptor [ Homo sapiens (human) ]

    Gene ID: 2149, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    PAR1-mediated Non-periodical Synchronized Calcium Oscillations in Human Mesangial Cells.

    PAR1-mediated Non-periodical Synchronized Calcium Oscillations in Human Mesangial Cells.
    Stefanenko M, Fedoriuk M, Mamenko M, Semenikhina M, Nowling TK, Lipschutz JH, Maximyuk O, Staruschenko A, Palygin O., Free PMC Article

    10/30/2024
    PAR1 Activation, via LMBR1/BMP Axis, Promotes the Osteogenesis of Periodontal Ligament Stem Cells (PDLSCs) and Alleviates the Inhibitory Effect of Sodium Butyrate on PDLSCs Osteogenesis.

    PAR1 Activation, via LMBR1/BMP Axis, Promotes the Osteogenesis of Periodontal Ligament Stem Cells (PDLSCs) and Alleviates the Inhibitory Effect of Sodium Butyrate on PDLSCs Osteogenesis.
    Xia L, Yang Z, Hu C.

    09/9/2024
    Amyloid beta protein negatively regulates human platelet activation induced by thrombin receptor-activating protein.

    Amyloid β protein negatively regulates human platelet activation induced by thrombin receptor-activating protein.
    Mizutani D, Tokuda H, Onuma T, Uematsu K, Nakashima D, Ueda K, Doi T, Enomoto Y, Matsushima-Nishiwaki R, Ogura S, Iida H, Kozawa O, Iwama T.

    07/28/2024
    KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.

    KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
    Wu K, Wu B, Yan K, Ding Q, Miao Z.

    03/13/2024
    Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin.

    Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin.
    Biswas I, Giri H, Panicker SR, Rezaie AR.,

    02/23/2024
    Thrombin receptor PAR1 silencing in endothelial colony-forming cells modifies stemness and vasculogenic properties.

    Thrombin receptor PAR1 silencing in endothelial colony-forming cells modifies stemness and vasculogenic properties.
    Smadja DM, Rossi E, Haviari S, Bieche I, Cras A, Gaussem P.

    12/15/2023
    Protease-Activated Receptor 1-Mediated Damage of Podocytes in Diabetic Nephropathy.

    Protease-Activated Receptor 1-Mediated Damage of Podocytes in Diabetic Nephropathy.
    Bohovyk R, Khedr S, Levchenko V, Stefanenko M, Semenikhina M, Kravtsova O, Isaeva E, Geurts AM, Klemens CA, Palygin O, Staruschenko A.,

    11/22/2023
    PAR1 regulates sepsis-induced vascular endothelial barrier dysfunction by mediating ERM phosphorylation via the RhoA/ROCK signaling pathway.

    PAR1 regulates sepsis-induced vascular endothelial barrier dysfunction by mediating ERM phosphorylation via the RhoA/ROCK signaling pathway.
    Zhao L, Hu J, Zheng P, Mi B, Chen Z, Zhao X, Wu J, Wang Y.

    11/6/2023
    Protease-Activated Receptor 1 (PAR1) Expression Contributes to HPV-Associated Oropharyngeal Cancer Prognosis.

    Protease-Activated Receptor 1 (PAR1) Expression Contributes to HPV-Associated Oropharyngeal Cancer Prognosis.
    Fujita Y, Fukuda Y, Sanuki F, Irei I, Monobe Y, Uno M, Akisada T, Shimoya K, Hara H, Moriya T., Free PMC Article

    09/27/2023
    Stage lighting on PAR-1: a step further in the understanding of acquired focal and segmental glomerulosclerosis.

    Stage lighting on PAR-1: a step further in the understanding of acquired focal and segmental glomerulosclerosis.
    Ollero M, Sahali D.

    07/25/2023
    Elevated serum PAR-1 levels as an emerging biomarker of inflammation to predict the dengue infection severity.

    Elevated serum PAR-1 levels as an emerging biomarker of inflammation to predict the dengue infection severity.
    Sibia RS, Sood A, Subedi A, Sharma A, Mittal A, Singh G, Singh TG, Jaura RS, Goyal S.

    01/28/2023
    Serum protease-activated receptor (PAR-1) levels as a potential biomarker for diagnosis of inflammation in type 2 diabetic patients.

    Serum protease-activated receptor (PAR-1) levels as a potential biomarker for diagnosis of inflammation in type 2 diabetic patients.
    Goyal S, Sood A, Gautam I, Pradhan S, Mondal P, Singh G, Jaura RS, Singh TG, Sibia RS.

    10/22/2022
    Associations of CYP2C19 and F2R genetic polymorphisms with platelet reactivity in Chinese ischemic stroke patients receiving clopidogrel therapy.

    Associations of CYP2C19 and F2R genetic polymorphisms with platelet reactivity in Chinese ischemic stroke patients receiving clopidogrel therapy.
    Zhang S, Zhu J, Li H, Li F, Zhu B, Li T, Fang S, Qin S.

    05/14/2022
    Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma.

    Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma.
    Gao Y, Xu Q, Li X, Guo Y, Zhang B, Jin Y, Zhu C, Shen Y, Yang P, Shi Y, Jin R, Liu D, Ouyang Y, Liu X, Wang W, Chen D, Yang T., Free PMC Article

    04/23/2022
    KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1.

    KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1.
    Hua Q, Sun Z, Liu Y, Shen X, Zhao W, Zhu X, Xu P., Free PMC Article

    02/5/2022
    Sex-specific platelet activation through protease-activated receptor-1 in patients undergoing cardiac catheterization.

    Sex-specific platelet activation through protease-activated receptor-1 in patients undergoing cardiac catheterization.
    Gremmel T, Michelson AD, Wadowski PP, Pultar J, Weikert C, Tscharre M, Lee S, Panzer S, Frelinger AL 3rd.

    02/5/2022
    Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1.

    Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1.
    D'Alessandro E, Scaf B, Munts C, van Hunnik A, Trevelyan CJ, Verheule S, Spronk HMH, Turner NA, Ten Cate H, Schotten U, van Nieuwenhoven FA., Free PMC Article

    01/8/2022
    Autoantibodies from Patients with Scleroderma Renal Crisis Promote PAR-1 Receptor Activation and IL-6 Production in Endothelial Cells.

    Autoantibodies from Patients with Scleroderma Renal Crisis Promote PAR-1 Receptor Activation and IL-6 Production in Endothelial Cells.
    Simon M, Lücht C, Hosp I, Zhao H, Wu D, Heidecke H, Witowski J, Budde K, Riemekasten G, Catar R., Free PMC Article

    12/18/2021
    PAR-1 Antagonism to Promote Gut Mucosa Healing in Crohn's Disease Patients: A New Avenue for CVT120165.

    PAR-1 Antagonism to Promote Gut Mucosa Healing in Crohn's Disease Patients: A New Avenue for CVT120165.
    Motta JP, Deraison C, Le Grand S, Le Grand B, Vergnolle N.

    12/4/2021
    Expression/Activation of PAR-1 in Airway Epithelial Cells of COPD Patients: Ex Vivo/In Vitro Study.

    Expression/Activation of PAR-1 in Airway Epithelial Cells of COPD Patients: Ex Vivo/In Vitro Study.
    Montalbano AM, Chiappara G, Albano GD, Ferraro M, Di Sano C, Vitulo P, Pipitone L, Ricciardolo FLM, Anzalone G, Profita M., Free PMC Article

    10/30/2021
    Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation.

    Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation.
    Tekin C, Aberson HL, Waasdorp C, Hooijer GKJ, de Boer OJ, Dijk F, Bijlsma MF, Spek CA., Free PMC Article

    08/7/2021
    Increased Pro-Thrombotic Platelet Activity Associated with Thrombin/PAR1-Dependent Pathway Disorder in Patients with Secondary Progressive Multiple Sclerosis.

    Increased Pro-Thrombotic Platelet Activity Associated with Thrombin/PAR1-Dependent Pathway Disorder in Patients with Secondary Progressive Multiple Sclerosis.
    Dziedzic A, Miller E, Bijak M, Przyslo L, Saluk-Bijak J., Free PMC Article

    02/27/2021
    KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.

    KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
    Billi AC, Ludwig JE, Fritz Y, Rozic R, Swindell WR, Tsoi LC, Gruzska D, Abdollahi-Roodsaz S, Xing X, Diaconu D, Uppala R, Camhi MI, Klenotic PA, Sarkar MK, Husni ME, Scher JU, McDonald C, Kahlenberg JM, Midura RJ, Gudjonsson JE, Ward NL., Free PMC Article

    02/6/2021
    F2R Polymorphisms and Clopidogrel Efficacy and Safety in Patients With Minor Stroke or TIA.

    F2R Polymorphisms and Clopidogrel Efficacy and Safety in Patients With Minor Stroke or TIA.
    Pan Y, Wangqin R, Li H, Wang Y, Meng X, Johnston SC, Simon T, Lin J, Zhao X, Liu L, Wang D, Wang Y.

    01/16/2021
    Protease-activated receptor signalling initiates alpha5beta1-integrin-mediated adhesion in non-haematopoietic cells.

    Protease-activated receptor signalling initiates α(5)β(1)-integrin-mediated adhesion in non-haematopoietic cells.
    Spoerri PM, Strohmeyer N, Sun Z, Fässler R, Müller DJ.

    11/28/2020
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