| Long-term safety and efficacy outcomes of valoctocogene roxaparvovec gene transfer up to 6 years post-treatment. | Long-term safety and efficacy outcomes of valoctocogene roxaparvovec gene transfer up to 6 years post-treatment.
Symington E, Rangarajan S, Lester W, Madan B, Pierce GF, Raheja P, Robinson TM, Osmond D, Russell CB, Vettermann C, Agarwal SK, Li M, Wong WY, Laffan M. | 03/29/2024 |
| An intronic RNA element modulates Factor VIII exon-16 splicing. | An intronic RNA element modulates Factor VIII exon-16 splicing.
Tse V, Chacaltana G, Gutierrez M, Forino NM, Jimenez AG, Tao H, Do PH, Oh C, Chary P, Quesada I, Hamrick A, Lee S, Stone MD, Sanford JR., Free PMC Article | 01/26/2024 |
| The role of proteolytic cleavage at Arg[336] and Arg[372] of the A1 domain in factor VIIa/tissue factor-catalyzed reactions of B domain-deleted factor VIII. | The role of proteolytic cleavage at Arg(336) and Arg(372) of the A1 domain in factor VIIa/tissue factor-catalyzed reactions of B domain-deleted factor VIII.
Nakajima Y, Nogami K. | 12/21/2023 |
| Coagulation factor VIII regulates von Willebrand factor homeostasis invivo. | Coagulation factor VIII regulates von Willebrand factor homeostasis invivo.
Cao W, Trask AR, Bignotti AI, George LA, Doshi BS, Sabatino DE, Yada N, Zheng L, Camire RM, Zheng XL., | 12/20/2023 |
| Factor VIII mutated with Lys1813Ala within the factor IXa-binding region enhances intrinsic coagulation potential. | Factor VIII mutated with Lys1813Ala within the factor IXa-binding region enhances intrinsic coagulation potential.
Nakajima Y, Takeyama M, Oda A, Shimonishi N, Nogami K., Free PMC Article | 08/11/2023 |
| Mechano-covalent protection of coagulation factor VIII by von Willebrand factor. | Mechano-covalent protection of coagulation factor VIII by von Willebrand factor.
Butera D, Wang HJ, Woon HG, Zhao YC, Ju LA, Hogg PJ., Free PMC Article | 05/31/2023 |
| Translational readthrough at F8 nonsense variants in the factor VIII B domain contributes to residual expression and lowers inhibitor association. | Translational readthrough at F8 nonsense variants in the factor VIII B domain contributes to residual expression and lowers inhibitor association.
Testa MF, Lombardi S, Bernardi F, Ferrarese M, Belvini D, Radossi P, Castaman G, Pinotti M, Branchini A., Free PMC Article | 02/11/2023 |
| Heterogeneity and reciprocity of FVIII and VWF expression, and the response to shear stress in cultured human endothelial cells. | Heterogeneity and reciprocity of FVIII and VWF expression, and the response to shear stress in cultured human endothelial cells.
Hough C, Notley C, Mo A, Videl B, Lillicrap D., Free PMC Article | 10/29/2022 |
| [Correlation Analysis of FGene Mutation and the Production of F Inhibitor with Severe Hemophilia A Patients in a Single Medical Center]. | [Correlation Analysis of FⅧGene Mutation and the Production of FⅧ Inhibitor with Severe Hemophilia A Patients in a Single Medical Center].
Zhu LK, Zhang XL, Liu XE, Qin XY, Wang G, Yang LH. | 10/15/2022 |
| Factor XIII-A Val34Leu and Tyr204Phe variants influence clot kinetics in a cohort of South African type 2 diabetes mellitus patients. | Factor XIII-A Val34Leu and Tyr204Phe variants influence clot kinetics in a cohort of South African type 2 diabetes mellitus patients.
Phasha MN, Soma P, Bester J, Pretorius E, Phulukdaree A. | 06/25/2022 |
| Unveiling the influence of factor VIII physicochemical properties on hemophilia A phenotype through an in silico methodology. | Unveiling the influence of factor VIII physicochemical properties on hemophilia A phenotype through an in silico methodology.
Meireles MR, Stelmach LH, Bandinelli E, Vieira GF. | 05/14/2022 |
| The role of factor XIII in surgery for advanced stage of epithelial ovarian cancer. | The role of factor XIII in surgery for advanced stage of epithelial ovarian cancer.
Yazdian M, Groeben H, Ataseven B, Schneider S, Baert T, Bommert M, Traut A, Elfers-Wassenhoven A, Brüß U, Schwameis R, du Bois A, Wagner U, Harter P. | 04/30/2022 |
| Factor VIII as a potential player in cancer pathophysiology. | Factor VIII as a potential player in cancer pathophysiology.
Walker GE, Merlin S, Zanolini D, Vandoni A, Volpe A, Gaidano G, Valente G, Olivero M, Follenzi A., Free PMC Article | 03/19/2022 |
| Exploring the Complex Role of Coagulation Factor VIII in Chronic Liver Disease. | Exploring the Complex Role of Coagulation Factor VIII in Chronic Liver Disease.
Pradhan-Sundd T, Gudapati S, Kaminski TW, Ragni MV., Free PMC Article | 03/12/2022 |
| Ectopic Expression of FVIII in HPCs and MSCs Derived from hiPSCs with Site-Specific Integration of ITGA2B Promoter-Driven BDDF8 Gene in Hemophilia A. | Ectopic Expression of FVIII in HPCs and MSCs Derived from hiPSCs with Site-Specific Integration of ITGA2B Promoter-Driven BDDF8 Gene in Hemophilia A.
Zhao J, Zhou M, Wang Z, Wu L, Hu Z, Liang D., Free PMC Article | 02/26/2022 |
| A founder effect in hemophilia A patients from Russian Ural region with a new p.(His634Arg) variant in F8 gene. | A founder effect in hemophilia A patients from Russian Ural region with a new p.(His634Arg) variant in F8 gene.
Salomashkina VV, Pshenichnikova OS, Perina FG, Surin VL. | 02/19/2022 |
| Acidic Region Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg1689. | Acidic Region Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg1689.
Nakajima Y, Minami H, Nogami K. | 02/12/2022 |
| Serum TNF-alpha Level as a Possible Predictor of Inhibitor Levels in Severe Hemophilia A. | Serum TNF-α Level as a Possible Predictor of Inhibitor Levels in Severe Hemophilia A.
Susanah S, Raspati H, Sari NM, Rakhmilla LE, Sribudiani Y, Moestopo O, Sinaga P, Idjradinata P, Maskoen AM., Free PMC Article | 01/22/2022 |
| X Chromosome inactivation: a modifier of factor VIII and IX plasma levels and bleeding phenotype in Haemophilia carriers. | X Chromosome inactivation: a modifier of factor VIII and IX plasma levels and bleeding phenotype in Haemophilia carriers.
Garagiola I, Mortarino M, Siboni SM, Boscarino M, Mancuso ME, Biganzoli M, Santagostino E, Peyvandi F., Free PMC Article | 01/22/2022 |
| Genetics and Hemostatic Potential in Persons with Mild to Moderate Hemophilia A with a Discrepancy between One-Stage and Chromogenic FVIII Assays. | Genetics and Hemostatic Potential in Persons with Mild to Moderate Hemophilia A with a Discrepancy between One-Stage and Chromogenic FVIII Assays.
Strålfors A, Mikovic D, Schmidt D, Onelöv L, Soutari NMH, Berndtson M, Chaireti R, Holmström M, Antovic JP, Bruzelius M. | 01/15/2022 |
| Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor. | Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor.
Ronayne EK, Peters SC, Gish JS, Wilson C, Spencer HT, Doering CB, Lollar P, Spiegel PC Jr, Childers KC., Free PMC Article | 12/18/2021 |
| Partial F8 gene duplication (factor VIII Padua) associated with high factor VIII levels and familial thrombophilia. | Partial F8 gene duplication (factor VIII Padua) associated with high factor VIII levels and familial thrombophilia.
Simioni P, Cagnin S, Sartorello F, Sales G, Pagani L, Bulato C, Gavasso S, Nuzzo F, Chemello F, Radu CM, Tormene D, Spiezia L, Hackeng TM, Campello E, Castoldi E. | 12/11/2021 |
| IVIg increases interleukin-11 levels, which in turn contribute to increased platelets, VWF and FVIII in mice and humans. | IVIg increases interleukin-11 levels, which in turn contribute to increased platelets, VWF and FVIII in mice and humans.
Nguyen A, Repesse Y, Ebbo M, Allenbach Y, Benveniste O, Vallat JM, Magy L, Deshayes S, Maigné G, de Boysson H, Karnam A, Delignat S, Lacroix-Desmazes S, Bayry J, Aouba A., Free PMC Article | 12/4/2021 |
| Spectrum of F8 Genotype and Genetic Impact on Inhibitor Development in Patients with Hemophilia A from Multicenter Cohort Studies (J-HIS) in Japan. | Spectrum of F8 Genotype and Genetic Impact on Inhibitor Development in Patients with Hemophilia A from Multicenter Cohort Studies (J-HIS) in Japan.
Shinozawa K, Yada K, Kojima T, Nogami K, Taki M, Fukutake K, Yoshioka A, Shirahata A, Shima M, study group on JAPAN HEMOPHILIA INHIBITOR STUDY (J-HIS). | 12/4/2021 |
| Role of ADAMTS13, VWF and F8 genes in deep vein thrombosis. | Role of ADAMTS13, VWF and F8 genes in deep vein thrombosis.
Pagliari MT, Cairo A, Boscarino M, Mancini I, Pappalardo E, Bucciarelli P, Martinelli I, Rosendaal FR, Peyvandi F., Free PMC Article | 11/27/2021 |