| REST Promotes Autophagy in Gastric Cancer by Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway. | REST Promotes Autophagy in Gastric Cancer by Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway.
Luo J, Yu H, Yuan Z, Tang W, Wang C. | 07/24/2024 |
| Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein. | Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein.
Horváth G, Balterer B, Micsonai A, Kardos J, Toke O., Free PMC Article | 10/22/2022 |
| Fatty Acid Binding Protein 6 Inhibition Decreases Cell Cycle Progression, Migration and Autophagy in Bladder Cancers. | Fatty Acid Binding Protein 6 Inhibition Decreases Cell Cycle Progression, Migration and Autophagy in Bladder Cancers.
Lin CH, Chang HH, Lai CR, Wang HH, Tsai WC, Tsai YL, Changchien CY, Cheng YC, Wu ST, Chen Y., Free PMC Article | 03/19/2022 |
| Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells. | Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells.
Pai FC, Huang HW, Tsai YL, Tsai WC, Cheng YC, Chang HH, Chen Y., Free PMC Article | 12/4/2021 |
| Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma. | Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma.
Wu G, Zhang Z, Tang Q, Liu L, Liu W, Li Q, Wang Q. | 02/6/2021 |
| Functional suppression of FABP7 significantly inhibited SKRC10 clear cell renal cell carcinoma (ccRCC) cells growth and resulted in a significant reduction of the invasive potential but did not cause growth inhibition of SKRC7 cells. Functional suppression of FABP6 resulted in significant growth inhibition of SKRC7 cells. This is the first report about the complementary role of FABP6 for FABP7 in ccRCC. | Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma.
Nagao K, Shinohara N, Smit F, de Weijert M, Jannink S, Owada Y, Mulders P, Oosterwijk E, Matsuyama H., Free PMC Article | 04/6/2019 |
| Experimental analysis showed the importance of LEF1, ETV4 and FABP6 as three co-regulated prognostic markers in patients with colorectal cancer metastasis. | An integrated study on TFs and miRNAs in colorectal cancer metastasis and evaluation of three co-regulated candidate genes as prognostic markers.
Eskandari E, Mahjoubi F, Motalebzadeh J. | 10/20/2018 |
| Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR | Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.
Horváth G, Bencsura Á, Simon Á, Tochtrop GP, DeKoster GT, Covey DF, Cistola DP, Toke O. | 06/28/2016 |
| Analysis of slow and fast motions in I-BABP indicates largely different energy landscapes for the apo and holo states suggesting that optimization of binding interactions might be achieved by altering the dynamic behavior of specific protein segments. | Temperature dependence of backbone dynamics in human ileal bile acid-binding protein: implications for the mechanism of ligand binding.
Horváth G, Egyed O, Toke O. | 10/25/2014 |
| show, using electrospray ionization mass spectroscopy, that human ILBP binds bile acids with a 3:1 ratio, even at low protein and ligand concentrations | Cooperativity and site selectivity in the ileal lipid binding protein.
Turpin ER, Fang HJ, Thomas NR, Hirst JD. | 02/1/2014 |
| Ursodeoxycholic acid induces unique conformational changes in IBABP. | Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα.
Fang C, Filipp FV, Smith JW., Free PMC Article | 07/7/2012 |
| NMR data are in agreement with a conformational selection model we proposed earlier for I-BABP and support the hypothesis of an allosteric mechanism of ligand binding | Internal motions and exchange processes in human ileal bile acid binding protein as studied by backbone (15)N nuclear magnetic resonance spectroscopy.
Horváth G, Király P, Tárkányi G, Toke O. | 05/5/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| The-putative functional-Thr79Met substitution of FABP6 confers a protective effect on type 2 diabetes in obese individuals. | Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals.
Fisher E, Grallert H, Klapper M, Pfäfflin A, Schrezenmeir J, Illig T, Boeing H, Döring F, Fisher E, Grallert H, Klapper M, Pfäfflin A, Schrezenmeir J, Illig T, Boeing H, Döring F. | 02/8/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals.
Fisher E, Grallert H, Klapper M, Pfäfflin A, Schrezenmeir J, Illig T, Boeing H, Döring F, Fisher E, Grallert H, Klapper M, Pfäfflin A, Schrezenmeir J, Illig T, Boeing H, Döring F. | 09/20/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation.
Fisher E, Nitz I, Lindner I, Rubin D, Boeing H, Möhlig M, Hampe J, Schreiber S, Schrezenmeir J, Döring F. | 03/13/2008 |
| The expression of FABP6 was higher in primary colorectal cancers and adenomas than in normal epithelium, but was dramatically decreased in lymph node metastases, suggesting that FABP6 may play an important role in early carcinogenesis. | Fatty acid binding protein 6 is overexpressed in colorectal cancer.
Ohmachi T, Inoue H, Mimori K, Tanaka F, Sasaki A, Kanda T, Fujii H, Yanaga K, Mori M. | 01/21/2010 |
| NMR structure of human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures | Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures.
Kurz M, Brachvogel V, Matter H, Stengelin S, Thüring H, Kramer W. | 01/21/2010 |
| ASBT and ILBP protein were 48% and 67% lower in normal weight gallstone carriers than in controls (P < 0.05); similar differences were found for mRNA expression levels. | Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers.
Bergheim I, Harsch S, Mueller O, Schimmel S, Fritz P, Stange EF. | 01/21/2010 |
| the I-BABP gene may be a novel target for PPAR in humans | The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors.
Landrier JF, Thomas C, Grober J, Zaghini I, Petit V, Poirier H, Niot I, Besnard P. | 01/21/2010 |
| In keeping with its role in the enterohepatic circulation and ileal reabsorption of bile acids, the gene promoter contains consensus elements for CDX2 and FXR. More than one transcription start site has been identified. | Human ileal bile acid-binding protein promoter and the effects of CDX2.
Barley NF, Taylor V, Shaw-Smith CJ, Chakravarty P, Howard A, Legon S, Walters JR. | 07/23/2004 |