| Tff3 Deficiency Differentially Affects the Morphology of Male and Female Intestines in a Long-Term High-Fat-Diet-Fed Mouse Model. | Tff3 Deficiency Differentially Affects the Morphology of Male and Female Intestines in a Long-Term High-Fat-Diet-Fed Mouse Model.
Šešelja K, Bazina I, Vrecl M, Farger J, Schicht M, Paulsen F, Baus Lončar M, Pirman T., Free PMC Article | 11/28/2023 |
| Tff3[-/-] Knock-Out Mice with Altered Lipid Metabolism Exhibit a Lower Level of Inflammation following the Dietary Intake of Sodium Chloride for One Week. | Tff3(-/-) Knock-Out Mice with Altered Lipid Metabolism Exhibit a Lower Level of Inflammation following the Dietary Intake of Sodium Chloride for One Week.
Kolobarić N, Mihalj M, Kozina N, Matić A, Mihaljević Z, Jukić I, Drenjančević I., Free PMC Article | 05/3/2023 |
| Augmented leptin-induced trefoil factor 3 expression and epidermal growth factor receptor transactivation differentially influences neoplasia progression in the stomach and colorectum of dietary fat-induced obese mice. | Augmented leptin-induced trefoil factor 3 expression and epidermal growth factor receptor transactivation differentially influences neoplasia progression in the stomach and colorectum of dietary fat-induced obese mice.
Kinoshita Y, Arita S, Ogawa T, Takenouchi A, Inagaki-Ohara K. | 10/22/2022 |
| Liver-specific decrease in Tff3 gene expression in infant mice perinatally exposed to 2,3,7,8-tetrabromodibenzofuran or 2,3,7,8-tetrachlorodibenzo-p-dioxin. | Liver-specific decrease in Tff3 gene expression in infant mice perinatally exposed to 2,3,7,8-tetrabromodibenzofuran or 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Kimura E, Suzuki G, Uramaru N, Kakeyama M, Maekawa F. | 02/19/2022 |
| TFF3 mediates the NF-kappaB/COX2 pathway to regulate PMN-MDSCs activation and protect against necrotizing enterocolitis. | TFF3 mediates the NF-κB/COX2 pathway to regulate PMN-MDSCs activation and protect against necrotizing enterocolitis.
Liu J, Yang Q, Chen Z, Lv S, Tang J, Xing Z, Shi M, Lei A, Xiao G, He Y. | 10/2/2021 |
| our results suggested that hepatic Tff3 could be effectively used as a potential therapy target for the treatment of nonalcoholic fatty liver disease | Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-α-mediated fatty acid oxidation.
Wu X, Zheng H, Yang R, Luan X, Zhang L, Jin Q, Jin Y, Xue J. | 03/28/2020 |
| Our results indicate that Tff3 depletion led to diminished ER stress response, specifically the PERK pathway. | Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3(-/-)/C57BL/6N Knockout and WT (C57BL/6N) Control Mice.
Kozina N, Mihaljević Z, Lončar MB, Mihalj M, Mišir M, Radmilović MD, Justić H, Gajović S, Šešelja K, Bazina I, Horvatić A, Matić A, Bijelić N, Rođak E, Jukić I, Drenjančević I., Free PMC Article | 02/29/2020 |
| Elevated expression of TFF3 was shown after skeletal trauma. The stimulatory effects on cell motility and migration of MPCs suggest a role of TFF3 in skeletal repair. | Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair.
Krüger K, Schmid S, Paulsen F, Ignatius A, Klinger P, Hotfiel T, Swoboda B, Gelse K., Free PMC Article | 02/15/2020 |
| Data show that trefoil factor 3 (TFF3) - leucine rich repeat receptor and nogo-interacting protein 2 (LINGO2) interactions disrupt EGFR-LINGO2 complexes resulting in enhanced epidermal growth factor receptor (EGFR) signaling. | TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths.
Belle NM, Ji Y, Herbine K, Wei Y, Park J, Zullo K, Hung LY, Srivatsa S, Young T, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR., Free PMC Article | 01/18/2020 |
| Tff3 deficiency affects the profile and accumulation of fatty acids in the liver, with no obvious oxidative stress increase, although expression/activity of monitored enzymes is changed as well as the level of SIRT1 and PPARgamma protein. | Trefoil Factor 3 Deficiency Affects Liver Lipid Metabolism.
Bujak M, Bujak IT, Sobočanec S, Mihalj M, Novak S, Ćosić A, Levak MT, Kopačin V, Mihaljević B, Balog T, Drenjančević I, Loncar MB. | 07/28/2018 |
| The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation | Localization of trefoil factor family peptide 3 (TFF3) in epithelial tissues originating from the three germ layers of developing mouse embryo.
Bijelić N, Belovari T, Tolušić Levak M, Baus Lončar M., Free PMC Article | 07/14/2018 |
| These studies reveal a new link between hepatic GALE activity and whole-body glucose homeostasis via regulation of hepatic Tff3 expression. | Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression.
Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE., Free PMC Article | 11/25/2017 |
| Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.( | Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.
Manko A, Motta JP, Cotton JA, Feener T, Oyeyemi A, Vallance BA, Wallace JL, Buret AG., Free PMC Article | 09/16/2017 |
| the Tg(Tff1-CreERT2;Tff2-rtTA;Tff3-Luc) strain can confer intermittent transgene expression to gastric epithelial cells that have undergone previous gene modification, and may be suitable to genetically model therapeutic intervention during development, tumorigenesis, and other genetically tractable diseases | Inducible gene modification in the gastric epithelium of Tff1-CreERT2, Tff2-rtTA, Tff3-luc mice.
Thiem S, Eissmann MF, Stuart E, Elzer J, Jonas A, Buchert M, Ernst M. | 05/20/2017 |
| TFF3 is regulated by food intake, improves glucose tolerance and induces mucinous metaplasia. | Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia.
Ge H, Gardner J, Wu X, Rulifson I, Wang J, Xiong Y, Ye J, Belouski E, Cao P, Tang J, Lee KJ, Coberly S, Wu X, Gupte J, Miao L, Yang L, Nguyen N, Shan B, Yeh WC, Véniant MM, Li Y, Baribault H., Free PMC Article | 03/12/2016 |
| TFF1 and TFF3 peptides might be involved in the complex processes of nervous system development and differentiation and brain plasticity. | Trefoil factor family peptides TFF1 and TFF3 in the nervous tissues of developing mouse embryo.
Belovari T, Bijelić N, Tolušić Levak M, Baus Lončar M., Free PMC Article | 12/5/2015 |
| The TFF3 was present in cartilage chondrocytes undergoing endochondral ossification, particularly in zone of proliferation, hypertrophy and calcification as well as in zone of cartilage degeneration during the monitored fetal period. | Trefoil factor family protein 3 (TFF3) is present in cartilage during endochondral ossification in the developing mouse fetus.
Bijelić N, Belovari T, Baus Lončar M. | 12/20/2014 |
| Intravenous administration of recombinant TFF3 reversed changes in cerebral injury. | Trefoil factor 3 as an endocrine neuroprotective factor from the liver in experimental cerebral ischemia/reperfusion injury.
Liu SQ, Roberts D, Zhang B, Ren Y, Zhang LQ, Wu YH., Free PMC Article | 08/9/2014 |
| Tff3 peptides are involved in glucose homeostasis and insulin sensitivity, providing a promising peptide on new therapies against the metabolic disorders associated with type 2 diabetes mellitus. | Tff3, as a novel peptide, regulates hepatic glucose metabolism.
Xue Y, Shen L, Cui Y, Zhang H, Chen Q, Cui A, Fang F, Chang Y., Free PMC Article | 07/12/2014 |
| The genetically deleting Tff3 in mice altered down-regulated Pttg1 and up-regulated serpina3n expression, indicating a potential role of these factors during the development of presbyacusis. | Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice.
Lubka-Pathak M, Shah AA, Gallozzi M, Müller M, Zimmermann U, Löwenheim H, Pfister M, Knipper M, Blin N, Schimmang T., Free PMC Article | 10/1/2011 |
| Tff3 knock out mice have lower body weight than wild-type mice. | The intestinal factor Tff3 and a miRNA network regulate murine caloric metabolism.
Shah AA, Leidinger P, Keller A, Wendschlag A, Backes C, Baus-Loncar M, Meese E, Blin N. | 09/17/2011 |
| Soy protein diet, but not Lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-alpha in colon of dextran sodium sulfate-induced colitis. | Soy protein diet, but not Lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-α in colon of dextran sodium sulfate-treated C57BL/6 mice.
Jiang H, Przybyszewski J, Mitra D, Becker C, Brehm-Stecher B, Tentinger A, MacDonald RS. | 08/27/2011 |
| results suggest that a diminution of the intestinal trefoil factor system may be involved in the acceleration of aging in SAM-P6 mice | Downregulation of trefoil factor 3 gene expression in the colon of the senescence-accelerated mouse (SAM)-P6 revealed by oligonucleotide microarray analysis.
Kawashima T, Okamoto K, Muraguchi T, Oku T, Shidoji Y. | 10/23/2010 |
| Loss of the barrier protective molecule TFF3 leads to a profound increase in susceptibility to DSS-induced colitis, and this can be abrogated by reducing Fuc-TVII-dependent leukocyte recruitment. | Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.
Beck PL, Ihara E, Hirota SA, MacDonald JA, Meng D, Nanthakumar NN, Podolsky DK, Xavier RJ., Free PMC Article | 07/19/2010 |
| Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. | Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency.
Podolsky DK, Gerken G, Eyking A, Cario E., Free PMC Article | 01/21/2010 |