| BIGH3 mediates apoptosis and gap junction failure in osteocytes during renal cell carcinoma bone metastasis progression. | BIGH3 mediates apoptosis and gap junction failure in osteocytes during renal cell carcinoma bone metastasis progression.
Pan T, Liu F, Hao X, Wang S, Wasi M, Song JH, Lewis VO, Lin PP, Moon B, Bird JE, Panaretakis T, Lin SH, Wu D, Farach-Carson MC, Wang L, Zhang N, An Z, Zhang XH, Satcher RL. | 07/1/2024 |
| A novel role of TGFBI in macrophage polarization and macrophage-induced pancreatic cancer growth and therapeutic resistance. | A novel role of TGFBI in macrophage polarization and macrophage-induced pancreatic cancer growth and therapeutic resistance.
Zhou J, Lyu N, Wang Q, Yang M, Kimchi ET, Cheng K, Joshi T, Tukuli AR, Staveley-O'Carroll KF, Li G. | 11/30/2023 |
| Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice. | Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice.
Leibing T, Riedel A, Xi Y, Adrian M, Krzistetzko J, Kirkamm C, Dormann C, Schledzewski K, Goerdt S, Géraud C., Free PMC Article | 09/15/2023 |
| TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway. | TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway.
Lee SG, Chae J, Woo SM, Seo SU, Kim HJ, Kim SY, Schlaepfer DD, Kim IS, Park HS, Kwon TK, Nam JO., Free PMC Article | 04/6/2023 |
| Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI. | Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI.
Lee SG, Kim JS, Kim HJ, Schlaepfer DD, Kim IS, Nam JO., Free PMC Article | 10/23/2021 |
| Protein Analysis of the TGFBI(R124H) Mouse Model Gives Insight into Phenotype Development of Granular Corneal Dystrophy. | Protein Analysis of the TGFBI(R124H) Mouse Model Gives Insight into Phenotype Development of Granular Corneal Dystrophy.
Lukassen MV, Poulsen ET, Donaghy J, Mogensen EH, Christie KA, Roshanravan H, DeDioniso L, Nesbit MA, Moore T, Enghild JJ. | 09/25/2021 |
| Transforming Growth Factor-induced Protein Promotes NF-kappaB-mediated Angiogenesis during Postnatal Lung Development. | Transforming Growth Factor-induced Protein Promotes NF-κB-mediated Angiogenesis during Postnatal Lung Development.
Liu M, Iosef C, Rao S, Domingo-Gonzalez R, Fu S, Snider P, Conway SJ, Umbach GS, Heilshorn SC, Dewi RE, Dahl MJ, Null DM, Albertine KH, Alvira CM., Free PMC Article | 03/28/2021 |
| Data suggest that big-h3 protein (BIGH3) acts as a tumor suppressor in the retina. | Bigh3 silencing increases retinoblastoma tumor growth in the murine SV40-TAg-Rb model.
Allaman-Pillet N, Oberson A, Schorderet DF., Free PMC Article | 09/2/2017 |
| findings demonstrate a novel role of lithium in the inhibition of colon cancer metastasis by blocking TGFBIp expression, and thereby TGFBIp-induced lymphangiogenesis, in primary tumors. | Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells.
Maeng YS, Lee R, Lee B, Choi SI, Kim EK., Free PMC Article | 12/24/2016 |
| TGF-beta-induced matricellular protein-null lungs displayed diminished elastic recoil and gas exchange efficiency | Initial Suppression of Transforming Growth Factor-β Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia.
Ahlfeld SK, Wang J, Gao Y, Snider P, Conway SJ., Free PMC Article | 09/10/2016 |
| Vicenin-2 and scolymoside could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. | Ameliorative Effect of Vicenin-2 and Scolymoside on TGFBIp-Induced Septic Responses.
Lee W, Ku SK, Bae JS. | 08/27/2016 |
| the data suggest a model by which cytokine-induced Myt3 suppression leads to Tgfbi de-repression and subsequently to impaired islet-cell migration, revealing a novel role for Myt3 in regulating islet-cell migration. | Myt3 Mediates Laminin-V/Integrin-β1-Induced Islet-Cell Migration via Tgfbi.
Tennant BR, Chen J, Shih AZ, Luciani DS, Hoffman BG., Free PMC Article | 06/28/2016 |
| Studies reveal that growth hormone (GH)increases TGFBI expression in a mouse and rat models of diabetic nephropathy (DN) which correlate with clinical results, and suggest that this mechanism can explain the podocytes depletion in DN. | Growth Hormone Induces Transforming Growth Factor-Beta-Induced Protein in Podocytes: Implications for Podocyte Depletion and Proteinuria.
Chitra PS, Swathi T, Sahay R, Reddy GB, Menon RK, Kumar PA. | 05/14/2016 |
| Tgfbi deficiency is associated with the degradation of cartilage matrix | Tgfbi deficiency leads to a reduction in skeletal size and degradation of the bone matrix.
Lee JM, Lee EH, Kim IS, Kim JE. | 10/3/2015 |
| The results support a novel inflammatory pathway for diabetic retinopathy. This pathway is initiated by TGFbeta released from macrophages, which promotes synthesis and release of BIGH3 protein by REC and REC apoptosis. | BIGH3 protein and macrophages in retinal endothelial cell apoptosis.
Mondragon AA, Betts-Obregon BS, Moritz RJ, Parvathaneni K, Navarro MM, Kim HS, Lee CF, LeBaron RG, Asmis R, Tsin AT., Free PMC Article | 08/22/2015 |
| TGFBI is a potential risk gene for human diabetes. | TGFBI (βIG-H3) is a diabetes-risk gene based on mouse and human genetic studies.
Han B, Luo H, Raelson J, Huang J, Li Y, Tremblay J, Hu B, Qi S, Wu J., Free PMC Article | 04/4/2015 |
| High blood TGFBIp levels were observed in cecal ligation and puncture (CLP)-induced septic mice. The absence of the TGFBIp gene in mice attenuated CLP-induced sepsis. | Transforming growth factor β-induced protein promotes severe vascular inflammatory responses.
Bae JS, Lee W, Nam JO, Kim JE, Kim SW, Kim IS. | 05/31/2014 |
| Collectively, our findings indicate that betaig-h3 promotes the fibrogenic influence of TGFbeta signaling, neutralizing the prochondrogenic influence of the hypoxic-inducible factor 1 activated by the microenvironment of limb mesenchymal aggregates. | βig-h3 potentiates the profibrogenic effect of TGFβ signaling on connective tissue progenitor cells through the negative regulation of master chondrogenic genes.
Lorda-Diez CI, Montero JA, Diaz-Mendoza MJ, Garcia-Porrero JA, Hurle JM., Free PMC Article | 07/13/2013 |
| the observed effect of TGFBI on bone mass and bone size was largely caused by the effect of TGFBI on periosteal bone formation | Targeted disruption of TGFBI in mice reveals its role in regulating bone mass and bone size through periosteal bone formation.
Yu H, Wergedal JE, Zhao Y, Mohan S. | 10/20/2012 |
| Blocking of betaig-h3 expression in E12.5 embryos with antisense oligodeoxynucleotides resulted in cleft of the secondary palate | A TGF-beta-induced gene, betaig-h3, is crucial for the apoptotic disappearance of the medial edge epithelium in palate fusion.
Choi KY, Kim HJ, Cho BC, Kim IS, Kim HJ, Ryoo HM. | 01/21/2010 |
| keratoepithelin may help to build up a bridge between collagen VI and yet unidentified muscle receptor | First molecular characterization and immunolocalization of keratoepithelin in adult human skeletal muscle.
Sciandra F, Morlacchi S, Allamand V, De Benedetti G, Macchia G, Petrucci TC, Bozzi M, Brancaccio A. | 01/21/2010 |
| Betaig-h3 may play a critical role as a regulator of chondrogenic differentiation in endochondral ossification. | Expression patterns of betaig-h3 in chondrocyte differentiation during endochondral ossification.
Han MS, Kim JE, Shin HI, Kim IS., Free PMC Article | 01/21/2010 |
| Recombinant beta ig-h3 and its FAS1 domain significantly inhibit in vitro osteoblast differentiation as evaluated by matrix mineralization/bone nodule formation. | Beta ig-h3 mediates osteoblast adhesion and inhibits differentiation.
Thapa N, Kang KB, Kim IS. | 01/21/2010 |
| During pregnancy, high levels of betaig-h3 mRNA were detected in the uterus on Day 4 of gestation, when the trophoblastic invasion of the implanted blastocysts was very active. | Dynamics of betaig-h3 mRNA expression during pregnancy in the uterus and the placenta of the mouse: a possible regulatory factor for trophoblastic invasion.
Uekita T, Kim YJ, Yamanouchi K, Tojo H, Tachi C. | 01/21/2010 |
| The spatiotemporal distribution of Beta-ig during various stages of murine development was examined and its ability to support adhesion of various cell types assessed | Developmental expression patterns of Beta-ig (betaIG-H3) and its function as a cell adhesion protein.
Ferguson JW, Mikesh MF, Wheeler EF, LeBaron RG. | 01/21/2010 |