| These data show that host cell-associated V-ATPase expression levels can affect breast cancer dissemination, at least in part, through Extracellular matrix remodeling. | Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer.
Katara GK, Kulshrestha A, Mao L, Wang X, Sahoo M, Ibrahim S, Pamarthy S, Suzue K, Shekhawat GS, Gilman-Sachs A, Beaman KD., Free PMC Article | 02/2/2019 |
| a2V deficiency disrupts the endolysosomal route in Notch and TGF signaling, thereby impairing mammary gland development. | The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling.
Pamarthy S, Mao L, Katara GK, Fleetwood S, Kulshreshta A, Gilman-Sachs A, Beaman KD., Free PMC Article | 09/2/2017 |
| The data provide novel evidence showing that a2V can regulate the apoptotic pathways, an essential testicular feature, and is necessary for efficient spermatogenesis. | Male fertility and apoptosis in normal spermatogenesis are regulated by vacuolar-ATPase isoform a2.
Jaiswal MK, Agrawal V, Katara GK, Pamarthy S, Kulshrestha A, Chaouat G, Gilman-Sachs A, Beaman KD. | 09/3/2016 |
| These observations suggest that a2V plays a crucial role in spermatogenesis by regulating testicular immune responses, and its inhibition in males leads to poor pregnancy outcome in females. | Vacuolar-ATPase isoform a2 regulates macrophages and cytokine profile necessary for normal spermatogenesis in testis.
Jaiswal MK, Katara GK, Mallers T, Chaouat G, Gilman-Sachs A, Beaman KD. | 10/4/2014 |
| Report Atp6v0a2 up-regulation/inflammatory response during preimplantation period of pregnancy may lead to successful pregnancy outcome. | V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy.
Jaiswal MK, Mallers TM, Larsen B, Kwak-Kim J, Chaouat G, Gilman-Sachs A, Beaman KD. | 09/1/2012 |
| Deceased expression of Atp6v0a2 in the various immune cell populations of the spleen and blood suggests that the maternal environment is not supportive to fetus and leads to poor pregnancy outcome in the abortion-prone mating model | Abortion-prone mating influences alteration of systemic a2 vacuolar ATPase expression in spleen and blood immune cells.
Jaiswal MK, Mallers TM, Kwong C, Chaouat G, Gilman-Sachs A, Beaman KD. | 08/11/2012 |
| a2V regulates the delicate cytokine and chemokine networks that coordinate the recruitment of macrophages for successful placental development and growth at the feto-maternal interface. | Placental ATPase expression is a link between multiple causes of spontaneous abortion in mice.
Jaiswal MK, Gilman-Sachs A, Chaouat G, Beaman KD. | 01/14/2012 |
| Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO. | Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO.
Merkulova M, Bakulina A, Thaker YR, Grüber G, Marshansky V. | 08/23/2010 |
| Immunolocalization demonstrated expression of all 'a' subunits in the proximal tubule and in the intercalated cells of the collecting system. PCR detected mRNAs encoding all four 'a' isoforms with a relative abundance in the following order: a4>a2=a1>a3. | Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron.
Schulz N, Dave MH, Stehberger PA, Chau T, Wagner CA. | 01/21/2010 |
| Data demonstrate the crucial role of early endosomal acidification and V-ATPase/ARNO/Arf6 interactions in the regulation of the endocytic degradative pathway. | V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V. | 01/21/2010 |
| These results suggest that ISF/ShIF confers stromal cells with enhanced supporting activities for HSCs by modulating Wnt-activity and the extracellular matrix. | Immune suppressor factor confers stromal cell line with enhanced supporting activity for hematopoietic stem cells.
Nakajima H, Shibata F, Fukuchi Y, Goto-Koshino Y, Ito M, Urano A, Nakahata T, Aburatani H, Kitamura T. | 01/21/2010 |