| USP12 regulates ER stress-associated osteogenesis in human periodontal ligament cells under tension stress. | USP12 regulates ER stress-associated osteogenesis in human periodontal ligament cells under tension stress.
Liu X, Wang B, Chang M, Zhang X, Zou H, Zhang Z, Han G. | 01/5/2024 |
| USP12 promotes nonsmall cell lung cancer progression through deubiquitinating and stabilizing RRM2. | USP12 promotes nonsmall cell lung cancer progression through deubiquitinating and stabilizing RRM2.
Chen C, Xue N, Liu K, He Q, Wang C, Guo Y, Tian J, Liu X, Pan Y, Chen G. | 09/23/2023 |
| USP12 positively regulates M-MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65. | USP12 positively regulates M-MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65.
Zhan X, He Q, Sheng J, Jiang X, Lin L, Huang Y, He S, Chen Y, Li L, Zeng Z, Hu S, Wang P, Zhang Y. | 12/3/2022 |
| USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade. | USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Yang Z, Xu G, Wang B, Liu Y, Zhang L, Jing T, Tang M, Xu X, Jiao K, Xiang L, Fu Y, Tang D, Zhang X, Jin W, Zhuang G, Zhao X, Liu Y., Free PMC Article | 08/28/2021 |
| Downregulation of USP12 inhibits tumor growth via the p38/MAPK pathway in hepatocellular carcinoma. | Downregulation of USP12 inhibits tumor growth via the p38/MAPK pathway in hepatocellular carcinoma.
Liu C, Li X, Feng G, Cao M, Liu F, Zhang G, Lu Y. | 05/15/2021 |
| WDR20 plays a crucial role in as a "targeting subunit" that modulates CRM1-dependent shuttling of the USP12/UAF1/WDR20 complex between the plasma membrane, cytoplasm and nucleus. | WDR20 regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus.
Olazabal-Herrero A, Sendino M, Arganda-Carreras I, Rodríguez JA. | 03/9/2019 |
| USP12 deubiquitinates MDM2 and AR, which in turn controls the levels of the TP53 tumour suppressor and AR oncogene in prostate cancer. | Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12.
McClurg UL, Chit NCTH, Azizyan M, Edwards J, Nabbi A, Riabowol KT, Nakjang S, McCracken SR, Robson CN. | 03/2/2019 |
| Findings indicate that deubiquitinase Usp12 (Usp12) overexpression accelerates autophagic flux and induces an approximately sixfold increase in autophagic structures as determined by ultrastructural analyses. | Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease.
Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Oliveira AO, Wong JS, Daub AC, Giorgini F, Muchowski P, Finkbeiner S., Free PMC Article | 01/5/2019 |
| Our results highlight the interfaces essential for regulation of USP12 activity and show a conserved second binding of UAF1 which could be important for regulatory functions independent of USP12 activity. | A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
Dharadhar S, Clerici M, van Dijk WJ, Fish A, Sixma TK., Free PMC Article | 12/23/2017 |
| UAF1 and WDR20 interact with USP12 at two distinct sites far from its catalytic center, allosterically activating the enzyme. | Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20.
Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D'Andrea AD, Zheng N., Free PMC Article | 08/26/2017 |
| Usp12 deubiquitylates and prevents lysosomal degradation of LAT and Trat1 to maintain the proximal TCR complex for the duration of signaling. | Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S., Free PMC Article | 07/16/2016 |
| Results suggest role for USP46/USP12 in Epstein-Barr virus induced growth transformation. | The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth.
Ohashi M, Holthaus AM, Calderwood MA, Lai CY, Krastins B, Sarracino D, Johannsen E., Free PMC Article | 04/2/2016 |
| Usp12 directly deubiquitinates and stabilises the Akt phosphatases PHLPP and PHLPPL resulting in decreased levels of active pAkt. | Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.
McClurg UL, Summerscales EE, Harle VJ, Gaughan L, Robson CN., Free PMC Article | 06/6/2015 |
| Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 and any one of these three USPs: USP1, USP12 and USP46. | E1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replication.
Lehoux M, Gagnon D, Archambault J., Free PMC Article | 10/4/2014 |
| our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival | WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1).
Gangula NR, Maddika S., Free PMC Article | 02/22/2014 |
| Usp12 acts in a pro-proliferative manner by stabilizing AR and enhancing its cellular function. | Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor.
Burska UL, Harle VJ, Coffey K, Darby S, Ramsey H, O'Neill D, Logan IR, Gaughan L, Robson CN., Free PMC Article | 01/25/2014 |
| The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. | The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.
Moretti J, Chastagner P, Liang CC, Cohn MA, Israël A, Brou C., Free PMC Article | 11/24/2012 |
| WDR20 serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP12 complexes | WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex.
Kee Y, Yang K, Cohn MA, Haas W, Gygi SP, D'Andrea AD., Free PMC Article | 05/10/2010 |
| two novel multisubunit deubiquitinating enzyme complexes containing USP12 and USP46, respectively. Both complexes contain the UAF1 protein as a bona fide subunit. Interestingly, UAF1 | UAF1 is a subunit of multiple deubiquitinating enzyme complexes.
Cohn MA, Kee Y, Haas W, Gygi SP, D'Andrea AD., Free PMC Article | 01/21/2010 |