| The role of cyclin Y in normal and pathological cells. | The role of cyclin Y in normal and pathological cells.
Opacka A, Żuryń A, Krajewski A, Mikołajczyk K., Free PMC Article | 03/28/2023 |
| Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling. | Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling.
Chen L, Wang X, Cheng H, Zhang W, Liu Y, Zeng W, Yu L, Huang C, Liu G. | 03/28/2021 |
| Cyclin Y is expressed in Platelets and Modulates Integrin Outside-in Signaling. | Cyclin Y is expressed in Platelets and Modulates Integrin Outside-in Signaling.
Kyselova A, Siragusa M, Anthes J, Solari FA, Loroch S, Zahedi RP, Walter U, Fleming I, Randriamboavonjy V., Free PMC Article | 03/13/2021 |
| Fisetin inhibits TET1 expression and reduces 5hmC modification in specific loci in the promoters of CCNY/CDK16 in HuRSCs. | Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell.
Si Y, Liu J, Shen H, Zhang C, Wu Y, Huang Y, Gong Z, Xue J, Liu T., Free PMC Article | 06/20/2020 |
| Cyclin Y and CDK16 complex is necessary for efficient AMPK-dependent activation of autophagy.This functional interaction is mediated by AMPK phosphorylating Serine 326 of Cyclin Y. | AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy.
Dohmen M, Krieg S, Agalaridis G, Zhu X, Shehata SN, Pfeiffenberger E, Amelang J, Bütepage M, Buerova E, Pfaff CM, Chanda D, Geley S, Preisinger C, Sakamoto K, Lüscher B, Neumann D, Vervoorts J., Free PMC Article | 05/23/2020 |
| increased expression of CCNY was significantly associated with cell proliferation and migration. | Cyclin Y Modulates the Proliferation, Invasion, and Metastasis of Hepatocellular Carcinoma Cells.
Shi K, Ru Q, Zhang C, Huang J., Free PMC Article | 09/8/2018 |
| Amplification of gene CCNY is associated with metastatic lung adenocarcinoma. | The genomic dynamics during progression of lung adenocarcinomas.
Yang B, Luo L, Luo W, Zhou Y, Yang C, Xiong T, Li X, Meng X, Li L, Zhang X, Wang Z, Wang Z., Free PMC Article | 05/19/2018 |
| findings revealed an unrecognized role of Caprin-2 in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14, Cyclin Y, and LRP5/6. | Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation.
Wang X, Jia Y, Fei C, Song X, Li L., Free PMC Article | 06/3/2017 |
| we believe that CCNY has biological effect in breast cancer (BC) development, and its inhibition via an RNA interference lentiviral system may provide a therapeutic option for BC | RNAi-mediated downregulation of cyclin Y to attenuate human breast cancer cell growth.
Yan F, Wang X, Zhu M, Hu X. | 03/11/2017 |
| CCNY was significantly upregulated in ovarian cancer cell lines and tissues. Significant association was observed between CCNY expression and clinicopathological stage and lymph node metastasis. It significantly exacerbated proliferation, migration, and invasion of A2780 cells, in vitro and in nude mice. It significantly increased c-Myc, cyclin D1, PFTK1, ki67, and OGT protein expressions in xenograft tumor tissues. | Cyclin Y regulates the proliferation, migration, and invasion of ovarian cancer cells via Wnt signaling pathway.
Liu H, Shi H, Fan Q, Sun X. | 02/18/2017 |
| Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3. | Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.
Shehata SN, Deak M, Morrice NA, Ohta E, Hunter RW, Kalscheuer VM, Sakamoto K., Free PMC Article | 11/14/2015 |
| Our findings highlight a PFTK1-CCNY complex in activating noncanonical Wnt signaling in HCC cells. | PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinoma.
Sun T, Co NN, Wong N. | 07/26/2014 |
| Human cyclin Y (CCNY) is a phosphoprotein in vivo and phosphorylation of CCNY by CDK14 triggers its ubiquitination and degradation. | Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation.
Li S, Song W, Jiang M, Zeng L, Zhu X, Chen J. | 07/12/2014 |
| Cyclin Y regulates the expression and membrane trafficing of PCTAIRE kinases (PCTK). (Review) | Orphan kinases turn eccentric: a new class of cyclin Y-activated, membrane-targeted CDKs.
Mikolcevic P, Rainer J, Geley S., Free PMC Article | 03/2/2013 |
| CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site. | Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.
Mikolcevic P, Sigl R, Rauch V, Hess MW, Pfaller K, Barisic M, Pelliniemi LJ, Boesl M, Geley S., Free PMC Article | 03/31/2012 |
| these results validated the role of CCNY as a clinically relevant human oncoprotein | Cell cycle protein cyclin Y is associated with human non-small-cell lung cancer proliferation and tumorigenesis.
Yue W, Zhao X, Zhang L, Xu S, Liu Z, Ma L, Jia W, Qian Z, Zhang C, Wang Y, Yang X. | 04/30/2011 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.
Cleynen I, Mahachie John JM, Henckaerts L, Van Moerkercke W, Rutgeerts P, Van Steen K, Vermeire S., Free PMC Article | 12/5/2010 |
| CCNY might play an important role in glioma tumorigenisis. | Lentivirus-mediated knockdown of cyclin Y (CCNY) inhibits glioma cell proliferation.
Xu Y, Wang Z, Wang J, Li J, Wang H, Yue W. | 05/31/2010 |
| Single nucleotide polymorphism in CCNY gene is associated with Crohn's disease and ulcerative colitis | Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.
Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S, Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (8) articlesComparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.
Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, Annese V, Dubinsky M, Rotter JI, Russell RK, Bradfield JP, Sleiman PM, Glessner JT, Walters T, Hou C, Kim C, Frackelton EC, Garris M, Doran J, Romano C, Catassi C, Van Limbergen J, Guthery SL, Denson L, Piccoli D, Silverberg MS, Stanley CA, Monos D, Wilson DC, Griffiths A, Grant SF, Satsangi J, Polychronakos C, Hakonarson H. Genetic risk profiling and prediction of disease course in Crohn's disease patients.
Henckaerts L, Van Steen K, Verstreken I, Cleynen I, Franke A, Schreiber S, Rutgeerts P, Vermeire S. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.
Weersma RK, Stokkers PC, Cleynen I, Wolfkamp SC, Henckaerts L, Schreiber S, Dijkstra G, Franke A, Nolte IM, Rutgeerts P, Wijmenga C, Vermeire S. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
Anderson CA, Massey DC, Barrett JC, Prescott NJ, Tremelling M, Fisher SA, Gwilliam R, Jacob J, Nimmo ER, Drummond H, Lees CW, Onnie CM, Hanson C, Blaszczyk K, Ravindrarajah R, Hunt S, Varma D, Hammond N, Lewis G, Attlesey H, Watkins N, Ouwehand W, Strachan D, McArdle W, Lewis CM, Wellcome Trust Case Control Consortium, Lobo A, Sanderson J, Jewell DP, Deloukas P, Mansfield JC, Mathew CG, Satsangi J, Parkes M. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.
Argyropoulos G, Stütz AM, Ilnytska O, Rice T, Teran-Garcia M, Rao DC, Bouchard C, Rankinen T. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.
Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S, Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 05/11/2008 |