| The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis. | The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis.
Song J, Zhang Y, Bai Y, Sun X, Lu Y, Guo Y, He Y, Gao M, Chi X, Heng BC, Zhang X, Li W, Xu M, Wei Y, You F, Zhang X, Lu D, Deng X., Free PMC Article | 11/1/2023 |
| The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region. | The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region.
Fan G, Wang F, Chen Y, Zheng Q, Xiong J, Lv Q, Wu K, Xiong J, Wei L, Li D, Zhang J, Zhang W, Li F. | 02/11/2023 |
| The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma. | The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma.
Vdovin A, Jelinek T, Zihala D, Sevcikova T, Durech M, Sahinbegovic H, Snaurova R, Radhakrishnan D, Turi M, Chyra Z, Popkova T, Venglar O, Hrdinka M, Hajek R, Simicek M., Free PMC Article | 11/19/2022 |
| OTUD1 deubiquitinase regulates NF-kappaB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways. | OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways.
Oikawa D, Gi M, Kosako H, Shimizu K, Takahashi H, Shiota M, Hosomi S, Komakura K, Wanibuchi H, Tsuruta D, Sawasaki T, Tokunaga F., Free PMC Article | 08/20/2022 |
| Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation. | Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation.
Woo SM, Seo SU, Min KJ, Kwon TK. | 01/22/2022 |
| OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. | OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation.
Luo Q, Wu X, Zhao P, Nan Y, Chang W, Zhu X, Su D, Liu Z., Free PMC Article | 12/4/2021 |
| The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity. | The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity.
Song J, Liu T, Yin Y, Zhao W, Lin Z, Yin Y, Lu D, You F., Free PMC Article | 06/5/2021 |
| OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3. | OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3.
Zhang Z, Wang D, Wang P, Zhao Y, You F. | 10/24/2020 |
| The data demonstrate that OTUD1 is involved in maintaining immune homeostasis and loss-of-function mutations of OTUD1 enhance the immune response and are associated with autoimmunity. | Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders.
Lu D, Song J, Sun Y, Qi F, Liu L, Jin Y, McNutt MA, Yin Y. | 10/5/2019 |
| Report that YAP is subject to non-proteolytic, K63-linked polyubiquitination by the SCF(SKP2) E3 ligase complex (SKP2), which is reversed by the deubiquitinase OTUD1. The non-proteolytic ubiquitination of YAP enhances its interaction with its nuclear binding partner TEAD, thereby inducing YAP's nuclear localization, transcriptional activity, and growth-promoting function. | SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity.
Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L., Free PMC Article | 12/22/2018 |
| we report the establishment of OTUD1-specific monoclonal antibodies (mAbs), using the rat medial iliac lymph node method. The generated antibodies recognize the N-terminal portion (aa. 1-290) of human and mouse OTUD1 proteins | Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 1.
Oikawa D, Shiota M, Goto E, Komakura K, Wanibuchi H, Tokunaga F. | 12/1/2018 |
| OTU deubiquitinase 1 (OTUD1) directly deubiquitinates Smad7 Protein (SMAD7) and prevents its degradation. | Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7.
Zhang Z, Fan Y, Xie F, Zhou H, Jin K, Shao L, Shi W, Fang P, Yang B, van Dam H, Ten Dijke P, Zheng X, Yan X, Jia J, Zheng M, Jin J, Ding C, Ye S, Zhou F, Zhang L., Free PMC Article | 10/6/2018 |
| these results suggest that OTUD1 is a novel regulator of p53 stability and activity. | Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53.
Piao S, Pei HZ, Huang B, Baek SH. | 12/2/2017 |
| OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer. | A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours.
Carneiro AP, Reis CF, Morari EC, Maia YC, Nascimento R, Bonatto JM, de Souza MA, Goulart LR, Ward LS., Free PMC Article | 09/27/2014 |