| Role of Thyrotropin-Releasing Hormone in Regulating Fibroblast Growth Factor 21 in Mouse Pancreatic beta Cells. | Role of Thyrotropin-Releasing Hormone in Regulating Fibroblast Growth Factor 21 in Mouse Pancreatic β Cells.
Garay Guerrero J, Ishida E, Shibusawa N, Lei X, Yamada S, Horiguchi K, Yamada M. | 02/22/2023 |
| Our results point out that cardiac TRH is required for AngII-induced hypertrophic and fibrotic effects. | Angiotensin II requires an intact cardiac thyrotropin-releasing hormone (TRH) system to induce cardiac hypertrophy in mouse.
Peres Diaz LS, Schuman ML, Aisicovich M, Toblli JE, Pirola CJ, Landa MS, García SI. | 10/26/2019 |
| TGFbeta2 regulates hypothalamic TRH expression through TIEG1 during fetal development. | TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
Martínez-Armenta M, Díaz de León-Guerrero S, Catalán A, Alvarez-Arellano L, Uribe RM, Subramaniam M, Charli JL, Pérez-Martínez L., Free PMC Article | 08/15/2015 |
| co-regulation of the enzyme glutaminyl cyclase and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta deposits | Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes.
Waniek A, Hartlage-Rübsamen M, Höfling C, Kehlen A, Schilling S, Demuth HU, Roßner S. | 03/21/2015 |
| RXRA and RXRB display specific roles in modulating T3-dependent regulation of thyrotropin releasing hormone. | Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription.
Decherf S, Seugnet I, Becker N, Demeneix BA, Clerget-Froidevaux MS. | 05/3/2014 |
| Reversal of hypothyroidism in female patient after treatment with thyrotropin releasing hormone. | Hypothalamic hypothyroidism due to isolated thyrotropin-releasing hormone (TRH) deficiency.
Katakami H, Kato Y, Inada M, Imura H. | 04/29/2013 |
| Data suggest that expression of TRH is up-regulated by CREM (cAMP responsive element modulator protein) in hypothalamus; however, regulation of TRH by triiodothyronine appears independent of CREM or CREB (cAMP responsive element binding protein). | Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus.
Chiappini F, Ramadoss P, Vella KR, Cunha LL, Ye FD, Stuart RC, Nillni EA, Hollenberg AN., Free PMC Article | 04/20/2013 |
| Thyrotropin-releasing hormone altered the basal expression of the TSHbeta gene and the responsiveness of the gene to thyroid hormone. | NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice.
Nakajima Y, Yamada M, Taguchi R, Shibusawa N, Ozawa A, Tomaru T, Hashimoto K, Saito T, Tsuchiya T, Okada S, Satoh T, Mori M., Free PMC Article | 04/6/2013 |
| Klf4 plays a key role in the maturation of TRH expression in hypothalamic neurons. | The Krüppel-like factor 4 controls biosynthesis of thyrotropin-releasing hormone during hypothalamus development.
Pérez-Monter C, Martínez-Armenta M, Miquelajauregui A, Furlan-Magaril M, Varela-Echavarría A, Recillas-Targa F, May V, Charli JL, Pérez-Martínez L. | 06/18/2011 |
| Data demonstrate that the distribution of hypophysiotropic TRH neurons in mice is vastly different from the pattern in rats, with a dominant occurrence of these neurosecretory cells in the compact part and adjacent regions at the mid-level of the PVN. | Distribution of hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons in the hypothalamic paraventricular nucleus of the mouse.
Kádár A, Sánchez E, Wittmann G, Singru PS, Füzesi T, Marsili A, Larsen PR, Liposits Z, Lechan RM, Fekete C., Free PMC Article | 12/11/2010 |
| These demonstrations of PPARgamma effects on hypothalamic Trh transcription in vivo consolidate the role of the TRH neuron as a central integrator of energy homeostasis. | Peroxisome proliferator-activated receptor-gamma (PPARgamma) modulates hypothalamic Trh regulation in vivo.
Kouidhi S, Seugnet I, Decherf S, Guissouma H, Elgaaied AB, Demeneix B, Clerget-Froidevaux MS. | 04/12/2010 |
| Results identify TRH as a modulator of orexin neuron firing in the hypothalamus, and suggest that orexin cell excitation may contribute to the arousal-enhancing actions of TRH. | Stimulation of orexin/hypocretin neurones by thyrotropin-releasing hormone.
González JA, Horjales-Araujo E, Fugger L, Broberger C, Burdakov D., Free PMC Article | 01/21/2010 |
| Direct receptor-mediated excitation of histaminergic tuberomamillary neurons by TRH demands activation of nonselective cation channels as well as electrogenic sodium/divalent calcium ion exchange. | Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone.
Parmentier R, Kolbaev S, Klyuch BP, Vandael D, Lin JS, Selbach O, Haas HL, Sergeeva OA., Free PMC Article | 01/21/2010 |
| TRH modulates behavioral arousal, in part, through the Hcrt system. | Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons.
Hara J, Gerashchenko D, Wisor JP, Sakurai T, Xie X, Kilduff TS., Free PMC Article | 01/21/2010 |
| TRH neurons in the hypothalamic paraventricular nucleus suggest that CB1 endocannabinoids may influence both excitatory and inhibitory inputs of these neurons. | Type 1 cannabinoid receptor-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons.
Deli L, Wittmann G, Kalló I, Lechan RM, Watanabe M, Liposits Z, Fekete C., Free PMC Article | 01/21/2010 |
| provide evidence in mice that TSH participates in this photoperiodic signal transduction | Involvement of thyrotropin in photoperiodic signal transduction in mice.
Ono H, Hoshino Y, Yasuo S, Watanabe M, Nakane Y, Murai A, Ebihara S, Korf HW, Yoshimura T., Free PMC Article | 01/21/2010 |
| Trh is expressed dynamically and specifically in the developing mouse definitive endoderm from E7.0 to E8.5 | Dynamic expression of thyrotropin-releasing hormone in the mouse definitive endoderm.
McKnight KD, Hou J, Hoodless PA. | 01/21/2010 |
| study provides functional in vivo data showing that both thyroid hormone receptor beta1 and beta2 isoforms have specific roles in regulating thyrotropin releasing hormone transcription | Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone.
Dupré SM, Guissouma H, Flamant F, Seugnet I, Scanlan TS, Baxter JD, Samarut J, Demeneix BA, Becker N. | 01/21/2010 |
| Detailed analysis of TRH-knockout mice might provide insight into physiological significance of endogenous TRH. Present review focuses on phenotypic findings of mice deficient in TRH. | Mice lacking the thyrotropin-releasing hormone gene: what do they tell us?
Yamada M, Satoh T, Mori M. | 01/21/2010 |
| TRH is not essential for pregnancy and lactation, but is required for full function of the lactotrophs, and the PRL mRNA level in the pituitary is regulated by TRH, both directly and indirectly via thyroid hormone | Prolactin secretion in mice with thyrotropin-releasing hormone deficiency.
Yamada M, Shibusawa N, Ishii S, Horiguchi K, Umezawa R, Hashimoto K, Monden T, Satoh T, Hirato J, Mori M. | 01/21/2010 |
| TRH is absolutely required for both TSH and TH synthesis but is not necessary for thyrotroph cell development | Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis.
Nikrodhanond AA, Ortiga-Carvalho TM, Shibusawa N, Hashimoto K, Liao XH, Refetoff S, Yamada M, Mori M, Wondisford FE. | 01/21/2010 |
| Expression of thyrotorpin receptors 1 and 2, key elements in TRH regulation, was modified by thyroid status in the hypothalamus but not in the cortex. | Thyroid status co-regulates thyroid hormone receptor and co-modulator genes specifically in the hypothalamus.
Clerget-Froidevaux MS, Seugnet I, Demeneix BA. | 01/21/2010 |
| experiments demonstrate that signal transducer and activator of transcription 3(STAT3) mediates transcriptional effects of leptin in vivo and that thyrotropin releasing hormone promoter is a likely direct site of leptin action | Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo.
Guo F, Bakal K, Minokoshi Y, Hollenberg AN. | 01/21/2010 |
| Released TRH is inactivated by an ectopeptidase, pyroglutamyl aminopeptidase II (PPII). Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions. | Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions.
de Gortari P, Romero F, Cisneros M, Joseph-Bravo P. | 06/21/2007 |
| There is considerable evidence linking alcohol consumption, sedation, and thyrotropin-releasing hormone (TRH) in the brain septum. | Effect of immobilization on in vitro thyrotropin-releasing hormone release from brain septum in wild-type and corticotropin-releasing hormone knock-out mice.
Kiss A, Adameová A, Kubovcáková L, Jamal B, Bacová Z, Zórad S, Tybitanclová K, Kvetnanský R, Strbák V. | 06/19/2007 |