| Spindle and kinetochore-related complex subunit 3 has a protumour function in osteosarcoma by activating the Notch pathway. | Spindle and kinetochore-related complex subunit 3 has a protumour function in osteosarcoma by activating the Notch pathway.
Liang G, Duan C, He J, Shi L. | 06/27/2024 |
| Specific intracellular retention of circSKA3 promotes colorectal cancer metastasis by attenuating ubiquitination and degradation of SLUG. | Specific intracellular retention of circSKA3 promotes colorectal cancer metastasis by attenuating ubiquitination and degradation of SLUG.
Deng J, Liao S, Chen C, Han F, Lei S, Lai X, Ye K, Han Q, E F, Lu C, Lai M, Liu F, Zhang H., Free PMC Article | 11/21/2023 |
| Hypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation. | Hypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation.
Chen Y, Xu X, Wang Y, Zhang Y, Zhou T, Jiang W, Wang Z, Chang J, Liu S, Chen R, Shan J, Wang J, Wang Y, Li C, Li X., Free PMC Article | 11/2/2023 |
| Transcription factor ZEB1 regulates PLK1-mediated SKA3 phosphorylation to promote lung cancer cell proliferation, migration and cell cycle. | Transcription factor ZEB1 regulates PLK1-mediated SKA3 phosphorylation to promote lung cancer cell proliferation, migration and cell cycle.
Ning G, Lu C, Chen Y, Jiang M, Si P, Zhang R. | 07/27/2023 |
| SKA3 is a prognostic biomarker and associated with immune infiltration in bladder cancer. | SKA3 is a prognostic biomarker and associated with immune infiltration in bladder cancer.
Wang C, Liu S, Zhang X, Wang Y, Guan P, Bu F, Wang H, Wang D, Fan Y, Hou S, Qiu Z., Free PMC Article | 06/11/2022 |
| SKA3 promotes glioblastoma proliferation and invasion by enhancing the activation of Wnt/beta-catenin signaling via modulation of the Akt/GSK-3beta axis. | SKA3 promotes glioblastoma proliferation and invasion by enhancing the activation of Wnt/β-catenin signaling via modulation of the Akt/GSK-3β axis.
Li C, Yang J, Lei S, Wang W. | 01/22/2022 |
| MiR-133b suppresses the proliferation, migration and invasion of lung adenocarcinoma cells by targeting SKA3. | MiR-133b suppresses the proliferation, migration and invasion of lung adenocarcinoma cells by targeting SKA3.
Zhang M, Lan X, Chen Y., Free PMC Article | 01/15/2022 |
| SKA3 Promotes Cell Growth in Breast Cancer by Inhibiting PLK-1 Protein Degradation. | SKA3 Promotes Cell Growth in Breast Cancer by Inhibiting PLK-1 Protein Degradation.
Ruan LW, Li PP, Jin LP., Free PMC Article | 12/4/2021 |
| Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma. | Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma.
Yu DC, Chen XY, Li X, Zhou HY, Yu DQ, Yu XL, Hu YC, Zhang RH, Zhang XB, Zhang K, An JD., Free PMC Article | 11/6/2021 |
| Circ-SKA3 Enhances Doxorubicin Toxicity in AC16 Cells Through miR-1303/TLR4 Axis. | Circ-SKA3 Enhances Doxorubicin Toxicity in AC16 Cells Through miR-1303/TLR4 Axis.
Li B, Cai X, Wang Y, Zhu H, Zhang P, Jiang P, Yang X, Sun J, Hong L, Shao L. | 10/16/2021 |
| Upregulation of SKA3 enhances cell proliferation and correlates with poor prognosis in hepatocellular carcinoma. | Upregulation of SKA3 enhances cell proliferation and correlates with poor prognosis in hepatocellular carcinoma.
Tang J, Liu J, Li J, Liang Z, Zeng K, Li H, Zhao Z, Zhou L, Jiang N. | 10/9/2021 |
| Spindle and kinetochoreassociated complex subunit 3 accelerates breast cancer cell proliferation and invasion through the regulation of Akt/Wnt/beta-catenin signaling. | Spindle and kinetochore‑associated complex subunit 3 accelerates breast cancer cell proliferation and invasion through the regulation of Akt/Wnt/β-catenin signaling.
Zhang J, Liu Y, Pu S, He J, Zhou C. | 08/14/2021 |
| Multisite phosphorylation determines the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation during mitosis. | Multisite phosphorylation determines the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation during mitosis.
Zhang Q, Hu L, Chen Y, Tian W, Liu H., Free PMC Article | 06/12/2021 |
| The Circular RNA circSKA3 Binds Integrin beta1 to Induce Invadopodium Formation Enhancing Breast Cancer Invasion. | The Circular RNA circSKA3 Binds Integrin β1 to Induce Invadopodium Formation Enhancing Breast Cancer Invasion.
Du WW, Yang W, Li X, Fang L, Wu N, Li F, Chen Y, He Q, Liu E, Yang Z, Awan FM, Liu M, Yang BB., Free PMC Article | 06/12/2021 |
| Circ-SKA3 upregulates ID3 expression by decoying miR-326 to accelerate the development of medulloblastoma. | Circ-SKA3 upregulates ID3 expression by decoying miR-326 to accelerate the development of medulloblastoma.
Zhao X, Guan J, Luo M. | 06/5/2021 |
| Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis. | Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis.
Gao W, Zhang Y, Luo H, Niu M, Zheng X, Hu W, Cui J, Xue X, Bo Y, Dai F, Lu Y, Yang D, Guo Y, Guo H, Li H, Zhang Y, Yang T, Li L, Zhang L, Hou R, Wen S, An C, Ma T, Jin L, Xu W, Wu Y., Free PMC Article | 05/22/2021 |
| SKA3 promotes lung adenocarcinoma metastasis through the EGFR-PI3K-Akt axis. | SKA3 promotes lung adenocarcinoma metastasis through the EGFR-PI3K-Akt axis.
Hu DD, Chen HL, Lou LM, Zhang H, Yang GL., Free PMC Article | 03/20/2021 |
| SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma. | SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma.
Hou Y, Wang Z, Huang S, Sun C, Zhao J, Shi J, Li Z, Wang Z, He X, Tam NL, Wu L., Free PMC Article | 09/12/2020 |
| decreased neuronal cell SKA complex genes' expression levels affect neuronal cell viability and neurite development | The stress response HPA-axis hormone, glucocorticoid, reduces cellular SKA complex gene expression.
Zhao J, Zhang P, He Z, Chen S, Golden T, Li L, Li M, Wu N. | 11/3/2018 |
| Study shows that Cdk1 phosphorylates Ska3 to promote its direct binding to the Ndc80 complex (Ndc80C), a core outer kinetochore component, also show that this phosphorylation occurs specifically during mitosis and is required for the kinetochore localization of the Ska complex. | Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression.
Zhang Q, Sivakumar S, Chen Y, Gao H, Yang L, Yuan Z, Yu H, Liu H. | 02/3/2018 |
| this report provides clear evidence that overexpression of the AURKA, SKA3, and DSN1 genes strongly correlates with the progression of colorectal adenomas to colorectal cancer | Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression.
Chuang TP, Wang JY, Jao SW, Wu CC, Chen JH, Hsiao KH, Lin CY, Chen SH, Su SY, Chen YJ, Chen YT, Wu DC, Li LH., Free PMC Article | 01/13/2018 |
| Kinetochores mature through Ska1/ska2/Ska3 complex recruitment and this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint. | Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment.
Auckland P, Clarke NI, Royle SJ, McAinsh AD., Free PMC Article | 09/16/2017 |
| over-expression of GNL3 and SKA3 in the PC-3 human prostate cancer cell line decreased in vitro cell migration and invasion | GNL3 and SKA3 are novel prostate cancer metastasis susceptibility genes.
Lee M, Williams KA, Hu Y, Andreas J, Patel SJ, Zhang S, Crawford NP. | 03/5/2016 |
| The structure of the Ska core complex is a W-shaped dimer of coiled coils, formed by intertwined interactions between Ska1, Ska2, and Ska3. | Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface.
Jeyaprakash AA, Santamaria A, Jayachandran U, Chan YW, Benda C, Nigg EA, Conti E. | 07/28/2012 |
| Data suggest that Aurora B phosphorylation antagonizes the interaction between the Ska1-3 complex and the KMN network, thereby controlling Ska recruitment to KTs and stabilization of KT-MT attachments. | Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction.
Chan YW, Jeyaprakash AA, Nigg EA, Santamaria A., Free PMC Article | 06/9/2012 |