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    FCGR3B Fc gamma receptor IIIb [ Homo sapiens (human) ]

    Gene ID: 2215, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of Fc Gamma Receptor 3B Gene Copy Number Variation with Rheumatoid Arthritis Susceptibility.

    Association of Fc Gamma Receptor 3B Gene Copy Number Variation with Rheumatoid Arthritis Susceptibility.
    Aslam MM, John P, Fan KH, Malik JM, Feingold E, Demirci FY, Kamboh MI., Free PMC Article

    01/11/2023
    Single-cell analyses identify dysfunctional CD16(+) CD8 T cells in smokers.

    Single-cell analyses identify dysfunctional CD16(+) CD8 T cells in smokers.
    Martos SN, Campbell MR, Lozoya OA, Wang X, Bennett BD, Thompson IJB, Wan M, Pittman GS, Bell DA., Free PMC Article

    02/26/2022
    Significant differences in FcgammaRIIa, FcgammaRIIIa and FcgammaRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.

    Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.
    Nasr A, Aljada A, Hamid O, Elsheikh HA, Masuadi E, Al-Bawab A, Alenazi TH, Abushouk A, Salah AM., Free PMC Article

    01/15/2022
    Low-affinity immunoglobulin gamma Fc region receptor III-B (FcgammaRIIIB, CD16B) deficiency in patients with blood and immune system disorders.

    Low-affinity immunoglobulin gamma Fc region receptor III-B (FcγRIIIB, CD16B) deficiency in patients with blood and immune system disorders.
    Minguela A, Salido EJ, Soto-Ramírez MF, Olga MA, Leal JD, García-Garay MC, Periago A, Berenguer M, Blanque M, Campillo JA.

    01/8/2022
    The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils.

    The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils.
    Alemán OR, Mora N, Rosales C., Free PMC Article

    10/2/2021
    Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.

    Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.
    Xiang Y, Liang B, Zhang X, Zheng F., Free PMC Article

    07/10/2021
    FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.

    FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.
    Moraru M, Perez-Portilla A, Al-Akioui Sanz K, Blazquez-Moreno A, Arnaiz-Villena A, Reyburn HT, Vilches C., Free PMC Article

    07/3/2021
    Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB.

    Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB.
    Fall AKDJ, Dechavanne C, Sabbagh A, Guitard E, Milet J, Garcia A, Dugoujon JM, Courtin D, Migot-Nabias F., Free PMC Article

    06/26/2021
    Aberrant FcgammaRIIb and FcgammaRIII expression on monocytes from patients with Behcet's disease.

    Aberrant FcγRIIb and FcγRIII expression on monocytes from patients with Behçet's disease.
    Huang L, Yu X, Li L, Liu J, Wu X, Zeng Y, Liao X, Liu W, Zhang F, Zhang X, Chen H, Zheng W.

    05/22/2021
    FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis.

    FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis.
    Alberici F, Bonatti F, Adorni A, Daminelli G, Sinico RA, Gregorini G, Marvisi C, Fenaroli P, Peyronel F, Maritati F, Palmisano A, Urban ML, Percesepe A, Emmi G, Martorana D, Vaglio A.

    04/24/2021
    Primary structure of human neutrophil antigens 1a and 1b.

    Primary structure of human neutrophil antigens 1a and 1b.
    Sachs UJ, Radke C, Bein G, Grabowski C, Simtong P, Bux J, Bayat B, Reil A.

    09/12/2020
    CCL3L1 and FCGR3B copy number variants may not be involved in susceptibility to ankylosing spondylitis risk in the Algerian population.

    Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population.
    Dahmani CA, Benzaoui A, Amroun H, Zemani-Fodil F, Petit-Teixeira E, Boudjema A.

    04/18/2020
    Study identified FcgammaRIIIb specific Asn45 glycosylation and an allelic effect on glycosylation at Asn162. FcgammaRIIIb specific glycosylation allows for assignment of FcgammaRIIIb alleles and relative copy number of the two alleles where DNA/RNA is not available. The types of structures found to be elevated at Asn162 in the NA2 allele are found to destabilize the Fc:FcgammaRIII interaction resulting in a faster diss...

    Characterization of Endogenous Human FcγRIII by Mass Spectrometry Reveals Site, Allele and Sequence Specific Glycosylation.
    Washburn N, Meccariello R, Duffner J, Getchell K, Holte K, Prod'homme T, Srinivasan K, Prenovitz R, Lansing J, Capila I, Kaundinya G, Manning AM, Bosques CJ., Free PMC Article

    11/30/2019
    Study data confirm FcgammaRIIIb as a negative regulator of neutrophil antibody-dependent cellular cytotoxicity toward tumor cells and a potential target for enhancing tumor cell destruction by neutrophils.

    FcγRIIIb Restricts Antibody-Dependent Destruction of Cancer Cells by Human Neutrophils.
    Treffers LW, van Houdt M, Bruggeman CW, Heineke MH, Zhao XW, van der Heijden J, Nagelkerke SQ, Verkuijlen PJJH, Geissler J, Lissenberg-Thunnissen S, Valerius T, Peipp M, Franke K, van Bruggen R, Kuijpers TW, van Egmond M, Vidarsson G, Matlung HL, van den Berg TK., Free PMC Article

    10/26/2019
    Collectively, these results indicate that the amino acid substitution Ala78Asp resulting in the HNA-1c allotype leads to higher affinity toward human IgG, enhancement of neutrophil activation, and possibly effective clearance of malaria by intracellular reactive oxygen species.

    Molecular and Functional Characterization of Fcγ Receptor IIIb-Ligand Interaction: Implications for Neutrophil-Mediated Immune Mechanisms in Malaria.
    Simtong P, Romphruk AV, Traum A, Burg-Roderfeld M, Bein G, Jakubowski K, Dominik A, Theisen M, Kana IH, Sachs UJ, Santoso S., Free PMC Article

    03/9/2019
    SHP-2 is activated by CD16b crosslinking in neutrophils.

    Neutrophil CD16b crosslinking induces lipid raft-mediated activation of SHP-2 and affects cytokine expression and retarded neutrophil apoptosis.
    Yang H, Jiang H, Song Y, Chen DJ, Shen XJ, Chen JH.

    09/8/2018
    FCGR3B deficiency due to copy number variations may predispose to eosinophilic granulomatosis with polyangiitis.

    Fcγ-receptor 3B (FCGR3B) copy number variations in patients with eosinophilic granulomatosis with polyangiitis.
    Martorana D, Bonatti F, Alberici F, Gioffredi A, Reina M, Urban ML, Maritati F, Adorni A, Radice A, Pizzolato S, Gregorini G, Jeannin G, Guida G, Boita M, Pesci A, Moroni G, Neri TM, Sinico RA, Vaglio A.

    07/21/2018
    low copy numbers of FCGR2A and FCGR3B to be common risk factors for systemic lupus nephritis (SLE) and ANCA-associated systemic vasculitis (AASV).

    Low copy numbers of FCGR3A and FCGR3B associated with Chinese patients with SLE and AASV.
    Qi Y, Zhou X, Bu D, Hou P, Lv J, Zhang H.

    06/9/2018
    The FCGR3B NA1/NA1 genotype is associated with hypersensitivity reactions to adalimumab in Japanese patients with Rheumatoid Arthritis.

    Fcγ receptor 3B polymorphism is associated with hypersensitivity reactions to adalimumab in Japanese patients with rheumatoid arthritis.
    Tsukamoto M, Kameda H, Ohshige T, Kaneko Y, Yoshimoto K, Suzuki K, Takeuchi T.

    04/14/2018
    Data suggest association of FCGR3B deletion with increased risk of rheumatoid arthritis (RA) in a large cohort.

    Understanding the Genomic Structure of Copy-Number Variation of the Low-Affinity Fcγ Receptor Region Allows Confirmation of the Association of FCGR3B Deletion with Rheumatoid Arthritis.
    Rahbari R, Zuccherato LW, Tischler G, Chihota B, Ozturk H, Saleem S, Tarazona-Santos E, Machado LR, Hollox EJ., Free PMC Article

    01/13/2018
    Gene copy number variation (CNV) of the PKLR, FCGR2A, FCGR2C, and FCGR3 genes is associated with malaria severity, and our results provide evidence for a role of CNV in host responses to malaria.

    Pyruvate Kinase and Fcγ Receptor Gene Copy Numbers Associated With Malaria Phenotypes.
    Faik I, van Tong H, Lell B, Meyer CG, Kremsner PG, Velavan TP.

    09/9/2017
    Association between Fc gamma Receptor IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya.

    Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya.
    Munde EO, Okeyo WA, Raballah E, Anyona SB, Were T, Ong'echa JM, Perkins DJ, Ouma C., Free PMC Article

    08/12/2017
    We conclude that FCGR3A CNVs are a major risk factor for female sarcoidosis and FCGR3B CNVs may also affect the development of sarcoidosis.

    FCGR3A and FCGR3B copy number variations are risk factors for sarcoidosis.
    Wu J, Li Y, Guan W, Viken K, Perlman DM, Bhargava M.

    06/24/2017
    CD16 and CD35 are important for neutrophil internalization of M. tuberculosis, whereas HIV-1 infection adversely affects opsonophagocytosis.

    Brief Report: HIV-1 Infection Impairs CD16 and CD35 Mediated Opsonophagocytosis of Mycobacterium tuberculosis by Human Neutrophils.
    Bangani N, Nakiwala J, Martineau AR, Wilkinson RJ, Wilkinson KA, Lowe DM., Free PMC Article

    06/24/2017
    There was no aberration in FCGR3B allele/genotype frequencies in sarcoidosis patients compared to controls.

    Polymorphism of FCGR2A, FCGR2C, and FCGR3B Genes in the Pathogenesis of Sarcoidosis.
    Typiak M, Rębała K, Dudziak M, Słomiński JM, Dubaniewicz A.

    06/24/2017
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