| [Clinical Significance of Thrombospondin Type 1 Domain-Containing 7A and Neural Epidermal Growth Factor-Like 1 Protein in M-Type Phospholipase A2 Receptor-Negative Membranous Nephropathy]. | [Clinical Significance of Thrombospondin Type 1 Domain-Containing 7A and Neural Epidermal Growth Factor-Like 1 Protein in M-Type Phospholipase A2 Receptor-Negative Membranous Nephropathy].
Tang XL, DU YY, Yu J, Ye T, Zhu H, Chen YF, Li XH. | 05/13/2023 |
| Comprehensively characterizing cellular changes and the expression of THSD7A and PLA2R1 under multiple in vitro models of podocyte injury. | Comprehensively characterizing cellular changes and the expression of THSD7A and PLA2R1 under multiple in vitro models of podocyte injury.
Zhang R, Shi Y, Lu Y, Wu Y, Chen M, Fan Y, Yuan L, Mao R. | 07/30/2022 |
| Clinical characteristics of thrombospondin type-1 domain-containing 7A-associated membranous nephropathy. | Clinical characteristics of thrombospondin type-1 domain-containing 7A-associated membranous nephropathy.
Suzuki T, Han W, Watanabe S, Terashita M, Nakata M, Ichikawa D, Shirai S, Shibagaki Y., Free PMC Article | 07/31/2021 |
| Case Report: THSD7A-Positive Membranous Nephropathy Caused by Tislelizumab in a Lung Cancer Patient. | Case Report: THSD7A-Positive Membranous Nephropathy Caused by Tislelizumab in a Lung Cancer Patient.
Chen M, Zhang L, Zhong W, Zheng K, Ye W, Wang M., Free PMC Article | 07/3/2021 |
| Autoantigens PLA2R and THSD7A in membranous nephropathy share a common epitope motif in the N-terminal domain. | Autoantigens PLA2R and THSD7A in membranous nephropathy share a common epitope motif in the N-terminal domain.
Fresquet M, Rhoden SJ, Jowitt TA, McKenzie EA, Roberts I, Lennon R, Brenchley PE., Free PMC Article | 06/12/2021 |
| Renal expression of PLA2R, THSD7A, and IgG4 in patients with membranous nephropathy and correlation with clinical findings. | Renal expression of PLA2R, THSD7A, and IgG4 in patients with membranous nephropathy and correlation with clinical findings.
Kaya B, Paydas S, Balal M, Eren Erdogan K, Gonlusen G. | 05/8/2021 |
| Expression of THSD7A in neoplasm tissues and its relationship with proteinuria. | Expression of THSD7A in neoplasm tissues and its relationship with proteinuria.
Xian L, Dong D, Luo J, Zhuo L, Li K, Zhang P, Wang W, Xu Y, Xu G, Wang L, Li G., Free PMC Article | 11/21/2020 |
| Results show a homology model of the extracellular portion of the thrombospondin type-1 domain containing 7A (THSD7A) antigen. | Structure and function insights garnered from in silico modeling of the thrombospondin type-1 domain-containing 7A antigen.
Stoddard SV, Welsh CL, Palopoli MM, Stoddard SD, Aramandla MP, Patel RM, Ma H, Beck LH Jr., Free PMC Article | 03/21/2020 |
| Human anti-THSD7A protein antibodies induce membranous nephropathy through activation of lectin complement pathway. | Human anti-thrombospondin type 1 domain-containing 7A antibodies induce membranous nephropathy through activation of lectin complement pathway.
Wang Z, Wen L, Dou Y, Zhao Z., Free PMC Article | 03/9/2019 |
| SCML4 and THSD7A are identified as novel susceptibility genes for coronary artery disease. | Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease.
Li Y, Wang DW, Chen Y, Chen C, Guo J, Zhang S, Sun Z, Ding H, Yao Y, Zhou L, Xu K, Song C, Yang F, Zhao B, Yan H, Wang WJ, Wu C, Lu X, Yang X, Dong J, Zheng G, Tian S, Cui Y, Jin L, Liu G, Cui H, Wang S, Jiang F, Wang C, Erdmann J, Zeng L, Huang S, Zhong J, Ma Y, Chen W, Sun J, Lei W, Chen S, Rao S, Gu D, Schunkert H, Tian XL. | 01/12/2019 |
| We propose a revised clinical workup flow for patients with MN that recommends assessment of kidney biopsy for PLA2R1 and THSD7A antigen expression, screening for circulating anti-podocytes antibodies, and assessment for secondary causes, especially cancer, in patients with THSD7A antibodies | Membranous Nephropathy and Anti-Podocytes Antibodies: Implications for the Diagnostic Workup and Disease Management.
Pozdzik A, Brochériou I, David C, Touzani F, Goujon JM, Wissing KM., Free PMC Article | 08/25/2018 |
| THSD7A-associated membranous nephropathy has a low prevalence in Chinese patients. | Circulating Antibodies against Thrombospondin Type-I Domain-Containing 7A in Chinese Patients with Idiopathic Membranous Nephropathy.
Wang J, Cui Z, Lu J, Probst C, Zhang YM, Wang X, Qu Z, Wang F, Meng LQ, Cheng XY, Liu G, Debiec H, Ronco P, Zhao MH., Free PMC Article | 06/16/2018 |
| Several risk alleles related to the PLA2R1 gene and within the HLA loci have been identified, whereas epitope spreading of PLA2R may predict treatment response. More recently, thrombospondin type 1 domain-containing 7A (THSD7A) antibodies have been discovered in primary membranous nephropathy . | Recent Progress in Deciphering the Etiopathogenesis of Primary Membranous Nephropathy.
Kronbichler A, Oh J, Meijers B, Mayer G, Shin JI., Free PMC Article | 05/12/2018 |
| Anti-M-type phospholipase A2 receptor (anti-PLA2R) and anti-THSD7A (thrombospondin type-1 domain-containing 7A) were detected only in membranous neurophathy (MN) patient sera and not in controls. | Biomarkers to detect membranous nephropathy in Chinese patients.
Lin L, Wang WM, Pan XX, Xu J, Gao CN, Zhang W, Ren H, Xie JY, Shen PY, Xu YW, Ni LY, Chen N., Free PMC Article | 02/17/2018 |
| High THSD7A expression is associated with membranous nephropathy and cancer. | THSD7A expression in human cancer.
Stahl PR, Hoxha E, Wiech T, Schröder C, Simon R, Stahl RA. | 07/22/2017 |
| This study provides novel data on the function of THSD7A in human placental cells, and extends knowledge of how miR-210 is involved in the development of the preeclampsia. | Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A.
Luo R, Wang Y, Xu P, Cao G, Zhao Y, Shao X, Li YX, Chang C, Peng C, Wang YL., Free PMC Article | 01/14/2017 |
| THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. | A novel gene THSD7A is associated with obesity.
Nizamuddin S, Govindaraj P, Saxena S, Kashyap M, Mishra A, Singh S, Rotti H, Raval R, Nayak J, Bhat BK, Prasanna BV, Dhumal VR, Bhale S, Joshi KS, Dedge AP, Bharadwaj R, Gangadharan GG, Nair S, Gopinath PM, Patwardhan B, Kondaiah P, Satyamoorthy K, Valiathan MS, Thangaraj K. | 09/24/2016 |
| Data indicate that enhanced granular expression of phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) was detected in 9.1% and 52.7%, respectively, of the patients with idiopathic membranous nephropathy (MN). | Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy.
Iwakura T, Ohashi N, Kato A, Baba S, Yasuda H., Free PMC Article | 06/28/2016 |
| 15 of 154 patients with idiopathic membranous nephropathy had circulating autoantibodies to THSD7A but not to PLA2R1, a finding that suggests a distinct subgroup of patients with this condition. | Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
Tomas NM, Beck LH Jr, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, Merchant M, Klein J, Salant DJ, Stahl RAK, Lambeau G., Free PMC Article | 01/10/2015 |
| results suggest that Japanese subjects homozygous for the risk alleles of rs7605378 in FONG and rs12673629 in THSD7A have a significantly higher risk of vertebral fracture | Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases.
Zhou H, Mori S, Kou I, Fuku N, Naka Mieno M, Honma N, Arai T, Sawabe M, Tanaka M, Ikegawa S, Ito H. | 07/27/2013 |
| THSD7A is a membrane-associated N-glycoprotein with a soluble form. | Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis.
Kuo MW, Wang CH, Wu HC, Chang SJ, Chuang YJ., Free PMC Article | 09/1/2012 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Novel association strategy with copy number variation for identifying new risk Loci of human diseases.
Chen X, Li X, Wang P, Liu Y, Zhang Z, Zhao G, Xu H, Zhu J, Qin X, Chen S, Hu L, Kong X., Free PMC Article | 12/5/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Thrombospondin type I domain containing 7A (THSD7A) mediates endothelial cell migration and tube formation. | Thrombospondin type I domain containing 7A (THSD7A) mediates endothelial cell migration and tube formation.
Wang CH, Su PT, Du XY, Kuo MW, Lin CY, Yang CC, Chan HS, Chang SJ, Kuo C, Seo K, Leung LL, Chuang YJ. | 01/25/2010 |
| Variations may be important determinants of osteoporosis in Japanese women. | Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis.
Mori S, Kou I, Sato H, Emi M, Ito H, Hosoi T, Ikegawa S. | 01/21/2010 |