| Transcriptome analysis revealed that deletion of NAPE-PLD activates a transcriptional program for nutrient transportation, including lipids and lipoproteins, and inactivates cell-cycle or mitosis-related genes in Caco-2 cells. | NAPE-PLD controls OEA synthesis and fat absorption by regulating lipoprotein synthesis in an in vitro model of intestinal epithelial cells.
Igarashi M, Watanabe K, Tsuduki T, Kimura I, Kubota N. | 11/23/2019 |
| The AC genotype and C allele of NAPE-PLD rs12540583 locus are risk factors for schizophrenia. | [Association of polymorphisms of NAPE-PLD and FAAH genes with schizophrenia in Chinese Han population].
Si P, Liu S, Tong D, Cheng M, Wang L, Cheng X. | 08/25/2018 |
| NAPE-PLD forms homodimers partly separated by an internal channel and uniquely adapted to associate with phospholipids. | Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids.
Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G., Free PMC Article | 12/5/2015 |
| our results do not support a clear role of FAAH, CNR1 and NAPE-PLD in BD and lithium response. | No association of endocannabinoid genes with bipolar disorder or lithium response in a Sardinian sample.
Pisanu C, Congiu D, Costa M, Sestu M, Chillotti C, Ardau R, Deiana V, Manchia M, Squassina A, Del Zompo M. | 08/8/2015 |
| a major physiological role of NAPE-PLD | Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D.
Guo L, Gragg SD, Chen Z, Zhang Y, Amarnath V, Davies SS., Free PMC Article | 05/17/2014 |
| The differential expression of NAPE-PLD and FAAH suggests that Anandamide could play an important role in the pathophysiology of preeclampsia. | Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis.
Abán C, Leguizamón GF, Cella M, Damiano A, Franchi AM, Farina MG. | 06/15/2013 |
| NAPE-PLD expression increase steadily after infancy, peaking in adulthood. | Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex.
Long LE, Lind J, Webster M, Weickert CS., Free PMC Article | 03/9/2013 |
| The results of this study suggested that NAPEPLD was alterated in multip;e sclerosis. | Cannabinoid receptor and N-acyl phosphatidylethanolamine phospholipase D--evidence for altered expression in multiple sclerosis.
Zhang H, Hilton DA, Hanemann CO, Zajicek J., Free PMC Article | 12/24/2011 |
| a common haplotype in NAPEPLD, an enzyme involved in endocannabinoid synthesis, was protective against obesity. | A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study).
Wangensteen T, Akselsen H, Holmen J, Undlien D, Retterstøl L, Wangensteen T, Akselsen H, Holmen J, Undlien D, Retterstøl L. | 10/8/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study).
Wangensteen T, Akselsen H, Holmen J, Undlien D, Retterstøl L, Wangensteen T, Akselsen H, Holmen J, Undlien D, Retterstøl L. | 12/5/2010 |
| During the menstrual cycle, NAPE-PLD immunoreactivity was down-regulated in the secretory epithelial gland compared to the proliferative epithelial gland and unaffected in the stroma. | Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle.
Taylor AH, Abbas MS, Habiba MA, Konje JC. | 09/27/2010 |
| The human NAPE-PLD was activated by phosphatidylethanolamine and inhibited by the beta-lactamase substrate nitrocefin. | Effect of synthetic and natural phospholipids on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D activity.
Petersen G, Pedersen AH, Pickering DS, Begtrup M, Hansen HS. | 03/15/2010 |