| Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice. | Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice.
Hoekstra M, Ren B, Laurila PP, Hildebrand RB, Soronen J, Frodermann V, Li Z, Boon MR, Geerling JJ, Rensen PCN, Jauhiainen M, Van Eck M., Free PMC Article | 11/13/2021 |
| Data suggest that the that the upstream transcription factor 1 (USF1) is indispensable for the proper maintenance of mammalian spermatogenesis. | Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice.
Faisal I, Cisneros-Montalvo S, Hamer G, Tuominen MM, Laurila PP, Tumiati M, Jauhiainen M, Kotaja N, Toppari J, Mäkelä JA, Kauppi L. | 12/21/2019 |
| The authors found that USF1 induced miR-125a-3p levels which suppressed Chi3L1 expression. Their results suggest that lung metastasis is suppressed by knock-down of Chi3L1 through miR-125a-3p-mediated up-regulation of USF1. | Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1.
Kim KC, Yun J, Son DJ, Kim JY, Jung JK, Choi JS, Kim YR, Song JK, Kim SY, Kang SK, Shin DH, Roh YS, Han SB, Hong JT., Free PMC Article | 09/7/2019 |
| ILEI contributes to melanoma cell invasiveness in vivo without affecting primary tumor growth and is transcriptionally up-regulated by USF-1. | Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1).
Noguchi K, Dincman TA, Dalton AC, Howley BV, McCall BJ, Mohanty BK, Howe PH., Free PMC Article | 02/9/2019 |
| Our findings identify USF1 as a novel factor regulating HDL functionality, showing that USF1 inactivation boosts cholesterol efflux, reduces macrophage inflammation and attenuates macrophage cholesterol accumulation, linking improved macrophage cholesterol metabolism and inflammatory pathways to the antiatherogenic function of USF1 deficiency. | USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages.
Ruuth M, Soronen J, Kaiharju E, Merikanto K, Perttilä J, Metso J, Lee-Rueckert M, Taskinen MR, Kovanen PT, Öörni K, Olkkonen VM, Jauhiainen MS, Laurila PP., Free PMC Article | 02/2/2019 |
| Mice lacking Usf1 displayed increased BAT-facilitated, diet-induced thermogenesis with up-regulation of mitochondrial respiratory chain complexes, as well as increased BAT activity even at thermoneutrality and after BAT sympathectomy | USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.
Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M. | 10/29/2016 |
| USF1 exclusively bound to the CACGTG E-box motifs in the brain cortex neuron proximal promoter regions. Importantly, functional annotation of the USF1-binding targets revealed an enrichment of genes related to lysosomal functions. | Genome-wide analyses in neuronal cells reveal that upstream transcription factors regulate lysosomal gene expression.
Yamanaka T, Tosaki A, Kurosawa M, Shimogori T, Hattori N, Nukina N. | 08/6/2016 |
| Propose that USF1 is an important modulator of molecular and behavioral circadian rhythms in mammals via DNA-binding of the CLOCK:BMAL1 complex. | Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.
Shimomura K, Kumar V, Koike N, Kim TK, Chong J, Buhr ED, Whiteley AR, Low SS, Omura C, Fenner D, Owens JR, Richards M, Yoo SH, Hong HK, Vitaterna MH, Bass J, Pletcher MT, Wiltshire T, Hogenesch J, Lowrey PL, Takahashi JS., Free PMC Article | 04/16/2016 |
| USF1 but not USF2 supports OPN expression in LRP6-VKO vascular smooth muscle lineage, and immunoprecipitation confirmed increased USF1 association with OPN chromatin. | Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.
Cheng SL, Ramachandran B, Behrmann A, Shao JS, Mead M, Smith C, Krchma K, Bello Arredondo Y, Kovacs A, Kapoor K, Brill LM, Perera R, Williams BO, Towler DA., Free PMC Article | 09/26/2015 |
| They underscore the new role of USF1 and give new clues of how p53 loss of function can occur in any cell type. | p53 requires the stress sensor USF1 to direct appropriate cell fate decision.
Bouafia A, Corre S, Gilot D, Mouchet N, Prince S, Galibert MD., Free PMC Article | 12/20/2014 |
| Pdx1, USF1 and USF2 co-ordinately regulate Alx3 gene expression in pancreatic beta-cells. | Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic β-cells.
Fernández-Pérez A, Vallejo M. | 11/22/2014 |
| USF1-centered regulatory networks were further confirmed by ChIP assays. | An integrated approach for the identification of USF1-centered transcriptional regulatory networks during liver regeneration.
Chen H, Lu S, Zhou J, Bai Z, Fu H, Xu X, Yang S, Jiao B, Sun Y. | 07/5/2014 |
| studies define the critical opposing functions of DREAM and USF1 in inhibiting and inducing A20 expression | The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation.
Tiruppathi C, Soni D, Wang DM, Xue J, Singh V, Thippegowda PB, Cheppudira BP, Mishra RK, Debroy A, Qian Z, Bachmaier K, Zhao YY, Christman JW, Vogel SM, Ma A, Malik AB., Free PMC Article | 04/26/2014 |
| AGTRAP expression is regulated by USF1 and USF2 | Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein.
Matsuda M, Tamura K, Wakui H, Maeda A, Ohsawa M, Kanaoka T, Azushima K, Uneda K, Haku S, Tsurumi-Ikeya Y, Toya Y, Maeshima Y, Yamashita A, Umemura S., Free PMC Article | 09/14/2013 |
| USF1 transactivates GATA5 expression by binding to the E-box in its promoter | Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif.
Chen B, Hsu R, Li Z, Kogut PC, Du Q, Rouser K, Camoretti-Mercado B, Solway J., Free PMC Article | 11/3/2012 |
| Data suggest that both USF1 and USF2 are essential for angiotensinogen (AGT) transcriptional regulation, and distinct sex-specific and tissue-specific mechanisms are involved in the activities of these transcription factors. | Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression.
Park S, Liu X, Davis DR, Sigmund CD., Free PMC Article | 07/28/2012 |
| using a mouse model we show that the loss of USF-1 compromises DNA repair, which suggests that USF-1 plays an important role in maintaining genomic stability. | USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions.
Baron Y, Corre S, Mouchet N, Vaulont S, Prince S, Galibert MD., Free PMC Article | 06/30/2012 |
| USF-1 binds the 5'PDbeta2 repressor element (E-box) in developing double-negative thymocytes. | DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.
Stone JL, McMillan RE, Skaar DA, Bradshaw JM, Jirtle RL, Sikes ML., Free PMC Article | 06/2/2012 |
| critical transcription factor regulating diabetic kidney disease and plays a critical role in albuminuria, mesangial matrix accumulation, and TGF-beta1 and renin stimulation in diabetic kidney disease | Role of the USF1 transcription factor in diabetic kidney disease.
Sanchez AP, Zhao J, You Y, Declèves AE, Diamond-Stanic M, Sharma K., Free PMC Article | 10/8/2011 |
| USF regulates globin gene expression indirectly by enhancing the expression of erythroid transcription factors and directly by mediating the recruitment of transcription complexes to the globin gene locus. | Defective erythropoiesis in transgenic mice expressing dominant-negative upstream stimulatory factor.
Liang SY, Moghimi B, Crusselle-Davis VJ, Lin IJ, Rosenberg MH, Li X, Strouboulis J, Huang S, Bungert J., Free PMC Article | 01/21/2010 |
| USF-1 specificity is directed via p38-mediated phosphorylation-dependent acetylation | Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation.
Corre S, Primot A, Baron Y, Le Seyec J, Goding C, Galibert MD., Free PMC Article | 01/21/2010 |
| Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis. | Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.
Kim JH, Kim K, Jin HM, Youn BU, Song I, Choi HS, Kim N. | 01/21/2010 |
| USF1 and USF2 bind the Fshr promoter and revealed differences between Sertoli and granulosa cells in compensatory responses to USF loss and the USF dimeric composition required for Fshr transcription | In vivo regulation of follicle-stimulating hormone receptor by the transcription factors upstream stimulatory factor 1 and upstream stimulatory factor 2 is cell specific.
Hermann BP, Hornbaker K, Rice DA, Sawadogo M, Heckert LL., Free PMC Article | 01/21/2010 |
| USF1 functionally and differentially regulates AGT expression via the -20 polymorphism and that the differential expression exhibited by -20 can be accounted for by differential association with USF1. | Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism.
Dickson ME, Tian X, Liu X, Davis DR, Sigmund CD., Free PMC Article | 01/21/2010 |
| In this study they asked whether the interactions between USF1/USF2 and E-Box and Nrf1 and GC-Box in the brain of mouse are influenced by postnatal age and what link it has with reported age-related decrease in the expression of Fmr-1 gene. | Interaction of USF1/USF2 and alpha-Pal/Nrf1 to Fmr-1 promoter increases in mouse brain during aging.
Prasad S, Singh K. | 01/21/2010 |