| Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion. | Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion.
Pilliod J, Desjardins A, Pernègre C, Jamann H, Larochelle C, Fon EA, Leclerc N., Free PMC Article | 04/3/2021 |
| in addition to a secretory role, VAMP8-mediates trafficking of NOX2 to endosomes and phagosomes and this promotes induction of cytolytic T cell immune responses | VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release.
Dingjan I, Paardekooper LM, Verboogen DRJ, von Mollard GF, Ter Beest M, van den Bogaart G., Free PMC Article | 06/9/2018 |
| This report highlights the importance of the VAMP8 secretory machinery in facilitating mucus release from intestinal goblet cells and the dire consequences that occur during disease pathogenesis if these pathways are not functional. | Entamoeba histolytica-Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense.
Cornick S, Moreau F, Gaisano HY, Chadee K., Free PMC Article | 05/26/2018 |
| acute inhibition of VAMP8-mediated secretion during pancreatitis triggers intracellular trypsin accumulation and loss of the early endosomal compartment | Acute acinar pancreatitis blocks vesicle-associated membrane protein 8 (VAMP8)-dependent secretion, resulting in intracellular trypsin accumulation.
Messenger SW, Jones EK, Holthaus CL, Thomas DDH, Cooley MM, Byrne JA, Mareninova OA, Gukovskaya AS, Groblewski GE., Free PMC Article | 07/15/2017 |
| These findings reveal a role for VAMP8 in LC3-associated phagocytosis and highlight a novel mechanism exploited by L. major promastigotes to interfere with the host antimicrobial machinery | Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63.
Matte C, Casgrain PA, Séguin O, Moradin N, Hong WJ, Descoteaux A., Free PMC Article | 06/24/2017 |
| VAMP8-mediated secretion is dependent on anterograde endosomal trafficking. | Vesicle associated membrane protein 8 (VAMP8)-mediated zymogen granule exocytosis is dependent on endosomal trafficking via the constitutive-like secretory pathway.
Messenger SW, Falkowski MA, Thomas DD, Jones EK, Hong W, Gaisano HY, Boulis NM, Groblewski GE., Free PMC Article | 12/20/2014 |
| Leishmania evades host immunity by GP63-mediated VAMP8 cleavage. | Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8.
Matheoud D, Moradin N, Bellemare-Pelletier A, Shio MT, Hong WJ, Olivier M, Gagnon E, Desjardins M, Descoteaux A. | 02/22/2014 |
| VAMP8 mediates insulin granule recruitment to the plasma membrane, which partly accounts for GLP-1 potentiation of glucose-stimulated insulin secretion. | Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth.
Zhu D, Zhang Y, Lam PP, Dolai S, Liu Y, Cai EP, Choi D, Schroer SA, Kang Y, Allister EM, Qin T, Wheeler MB, Wang CC, Hong WJ, Woo M, Gaisano HY. | 01/12/2013 |
| VAMP8 knockout mice were used to show that the SNARE machinery plays a critical role in the process of granule homotypic fusion. | VAMP8/endobrevin is a critical factor for the homotypic granule growth in pancreatic acinar cells.
Hammel I, Wang CC, Hong W, Amihai D. | 10/6/2012 |
| VAMP8 regulates mucin granule exocytosis in airway goblet cells, and reduction of its expression may provide a novel therapeutic target to ameliorate airway mucus obstruction in lung diseases | VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells.
Jones LC, Moussa L, Fulcher ML, Zhu Y, Hudson EJ, O'Neal WK, Randell SH, Lazarowski ER, Boucher RC, Kreda SM., Free PMC Article | 06/23/2012 |
| that granule-to-granule fusion is regulated by VAMP8 containing SNARE complexes distinct from those that regulate primary granule fusion. | Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion.
Behrendorff N, Dolai S, Hong W, Gaisano HY, Thorn P., Free PMC Article | 10/22/2011 |
| data demonstrate that, in the absence of VAMP8, the relative subcellular distribution of GLUT4 is altered, resulting in increased sarcolemma levels that can account for increased glucose clearance and insulin sensitivity | Enhanced energy expenditure, glucose utilization, and insulin sensitivity in VAMP8 null mice.
Zong H, Wang CC, Vaitheesvaran B, Kurland IJ, Hong W, Pessin JE., Free PMC Article | 02/26/2011 |
| VAMP8 mediates the regulated fusion of AQP2-positive vesicles with the plasma membrane. | A role for VAMP8/endobrevin in surface deployment of the water channel aquaporin 2.
Wang CC, Ng CP, Shi H, Liew HC, Guo K, Zeng Q, Hong W., Free PMC Article | 01/21/2010 |
| Results clearly show that VAMP8 is one of the v-SNARE that regulate the lytic ability of CTL by influencing the ability of the lytic granules to fuse with the plasma membrane and release its contents. | A role for endobrevin/VAMP8 in CTL lytic granule exocytosis.
Loo LS, Hwang LA, Ong YM, Tay HS, Wang CC, Hong W. | 01/21/2010 |
| Data show that in VAMP-8-deficient cells constitutive vesicular trafficking mechanisms are perturbed as indicated by increased SNARE complex formation between VAMP-3 and SNAP-23. | Increased formation of VAMP-3-containing SNARE complexes in mast cells from VAMP-8 deficient cells. appetite.
Tiwari N, Wang CC, Brochetta C, Scandiuzzi L, Hong W, Blank U. | 01/21/2010 |
| Simultaneous disruption of VAMPs 2, 3 and 8 completely inhibited insulin-stimulated GLUT4 insertion into the plasma membrane. | Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes.
Zhao P, Yang L, Lopez JA, Fan J, Burchfield JG, Bai L, Hong W, Xu T, James DE. | 01/21/2010 |
| these results highlight the role of caspases in regulating VAMP-8 expression and subsequently phagocytosis during maturation of dendritic cells. | Caspases regulate VAMP-8 expression and phagocytosis in dendritic cells.
Ho YH, Cai DT, Huang D, Wang CC, Wong SH. | 01/21/2010 |
| VAMP8 has a specific function in the thymic stroma affecting the proliferation and apoptosis of T lymphocytes during maturation in the thymus. | Thymic alterations in mice deficient for the SNARE protein VAMP8/endobrevin.
Kanwar N, Fayyazi A, Backofen B, Nitsche M, Dressel R, von Mollard GF., Free PMC Article | 01/21/2010 |
| VAMP8 is the zymogen granule-SNARE that mediates basolateral exocytosis in alcoholic pancreatitis. In addition, VAMP8 is critical for zymogen granule-zymogen granule homotypic fusion. | VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis.
Cosen-Binker LI, Binker MG, Wang CC, Hong W, Gaisano HY., Free PMC Article | 01/21/2010 |
| Functionally inhibits phagocytosis in dendritic cells upon exposure to bacteria | Vesicle-associated membrane protein-8/endobrevin negatively regulates phagocytosis of bacteria in dendritic cells.
Ho YH, Cai DT, Wang CC, Huang D, Wong SH. | 01/21/2010 |
| VAMP-8 segregates secretory lysosomal granule exocytosis in mast cells from cytokine/chemokine molecular trafficking pathways. | VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways.
Tiwari N, Wang CC, Brochetta C, Ke G, Vita F, Qi Z, Rivera J, Soranzo MR, Zabucchi G, Hong W, Blank U. | 01/21/2010 |
| These results suggest that VAMP8 may act as a v-SNARE for regulated secretion of the entire exocrine system. | VAMP8/endobrevin as a general vesicular SNARE for regulated exocytosis of the exocrine system.
Wang CC, Shi H, Guo K, Ng CP, Li J, Gan BQ, Chien Liew H, Leinonen J, Rajaniemi H, Zhou ZH, Zeng Q, Hong W., Free PMC Article | 01/21/2010 |
| VAMP8 has a role in regulated exocytosis of pancreatic acinar cells by serving as a v-SNARE of zymogen granules | A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells.
Wang CC, Ng CP, Lu L, Atlashkin V, Zhang W, Seet LF, Hong W. | 01/21/2010 |
| VAMP-8 is required for release from dense core granules, alpha granules, and lysosomes. | Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reaction.
Ren Q, Barber HK, Crawford GL, Karim ZA, Zhao C, Choi W, Wang CC, Hong W, Whiteheart SW., Free PMC Article | 01/21/2010 |