| The endonuclease FEN1 mediates activation of STAT3 and facilitates proliferation and metastasis in breast cancer. | The endonuclease FEN1 mediates activation of STAT3 and facilitates proliferation and metastasis in breast cancer.
Wu M, Huang X, Wu B, Zhu M, Zhu Y, Yu L, Lan T, Liu J. | 05/7/2024 |
| FEN1 Inhibition as a Potential Novel Targeted Therapy against Breast Cancer and the Prognostic Relevance of FEN1. | FEN1 Inhibition as a Potential Novel Targeted Therapy against Breast Cancer and the Prognostic Relevance of FEN1.
Berfelde J, Hildebrand LS, Kuhlmann L, Fietkau R, Distel LV., Free PMC Article | 03/13/2024 |
| Post-translational Modifications by Acyl Groups Regulate FEN1's Activities and Play Essential Roles in Cell Proliferation and DNA Repair. | Post-translational Modifications by Acyl Groups Regulate FEN1's Activities and Play Essential Roles in Cell Proliferation and DNA Repair.
Xiao Y, Yin M, Wang Y, Shi R, Mao S, Hua Y, Xu H. | 08/30/2023 |
| Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-gamma/JAK/STAT-1. | Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1.
Wang S, Wang X, Sun J, Yang J, Wu D, Wu F, Zhou H., Free PMC Article | 05/24/2023 |
| Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair. | Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair.
Laverde EE, Polyzos AA, Tsegay PP, Shaver M, Hutcheson JD, Balakrishnan L, McMurray CT, Liu Y, Laverde EE, Polyzos AA, Tsegay PP, Shaver M, Hutcheson JD, Balakrishnan L, McMurray CT, Liu Y., Free PMC Articles: PMC9859040, PMC9859040 | 02/11/2023 |
| Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair. | Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair.
Laverde EE, Polyzos AA, Tsegay PP, Shaver M, Hutcheson JD, Balakrishnan L, McMurray CT, Liu Y, Laverde EE, Polyzos AA, Tsegay PP, Shaver M, Hutcheson JD, Balakrishnan L, McMurray CT, Liu Y., Free PMC Articles: PMC9859040, PMC9859040 | 02/9/2023 |
| Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics. | Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics.
Raducanu VS, Tehseen M, Al-Amodi A, Joudeh LI, De Biasio A, Hamdan SM., Free PMC Article | 12/3/2022 |
| The Contribution of Flap Endonuclease 1 Genotypes to Oral Cancer Risk. | The Contribution of Flap Endonuclease 1 Genotypes to Oral Cancer Risk.
Pan SH, Chien WC, He JL, Shih LC, Hsu CL, Hsia TC, Wang YC, Tsao HY, Tsai CW, Bau DT, Chang WS. | 09/3/2022 |
| FEN1 Status and Its Correlation with Clinicopathologic Characteristic in Colorectal Cancer. | FEN1 Status and Its Correlation with Clinicopathologic Characteristic in Colorectal Cancer.
Guo Y, Du Z, Zhou Y, Sun H, Liang R, Sun MX, Tang Z, Liu SB. | 05/21/2022 |
| miR-4324 inhibits ovarian cancer progression by targeting FEN1. | miR-4324 inhibits ovarian cancer progression by targeting FEN1.
Wu H, Yan Y, Yuan J, Luo M, Wang Y., Free PMC Article | 03/19/2022 |
| One-Step Enzymatic Labeling Reveals a Critical Role of O-GlcNAcylation in Cell-Cycle Progression and DNA Damage Response. | One-Step Enzymatic Labeling Reveals a Critical Role of O-GlcNAcylation in Cell-Cycle Progression and DNA Damage Response.
Tian Y, Zhu Q, Sun Z, Geng D, Lin B, Su X, He J, Guo M, Xu H, Zhao Y, Qin W, Wang PG, Wen L, Yi W. | 12/18/2021 |
| Setting molecular traps in yeast for identification of anticancer drug targets. | Setting molecular traps in yeast for identification of anticancer drug targets.
Brown GW, Andrews B., Free PMC Article | 12/4/2021 |
| The interaction effects of FEN1 rs174538 polymorphism and polycyclic aromatic hydrocarbon exposure on damage in exon 19 and 21 of EGFR gene in coke oven workers. | The interaction effects of FEN1 rs174538 polymorphism and polycyclic aromatic hydrocarbon exposure on damage in exon 19 and 21 of EGFR gene in coke oven workers.
Chen S, He Y, Yan M, Zhou Y, He Q, Tan J, Yang B. | 11/27/2021 |
| The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ. | The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ.
Al-Kawaz A, Miligy IM, Toss MS, Mohammed OJ, Green AR, Madhusudan S, Rakha EA., Free PMC Article | 09/11/2021 |
| MicroRNA-134-3p inhibits ovarian cancer progression by targeting flap structure-specific endonuclease 1 in vitro. | MicroRNA-134-3p inhibits ovarian cancer progression by targeting flap structure-specific endonuclease 1 in vitro.
Zhao M, Ji H, Fu Q, Cheng Q, Zhang Y, Yang Y., Free PMC Article | 09/4/2021 |
| Targeting FEN1 Suppresses the Proliferation of Chronic Myeloid Leukemia Cells Through Regulating Alternative End-Joining Pathways. | Targeting FEN1 Suppresses the Proliferation of Chronic Myeloid Leukemia Cells Through Regulating Alternative End-Joining Pathways.
Zhu Y, Dai H, Wang Y, Liang Y, Feng W, Yuan Y. | 08/14/2021 |
| Biological and clinical significance of flap endonuclease1 in triplenegative breast cancer: Support of metastasis and a poor prognosis. | Biological and clinical significance of flap endonuclease‑1 in triple‑negative breast cancer: Support of metastasis and a poor prognosis.
Xu L, Qu JL, Song N, Zhang LY, Zeng X, Che XF, Hou KZ, Shi S, Feng ZY, Qu XJ, Liu YP, Teng YE., Free PMC Article | 07/31/2021 |
| Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks. | Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks.
Schilling EM, Scherer M, Rothemund F, Stamminger T., Free PMC Article | 07/24/2021 |
| miR1405p inhibits cervical cancer cell phenotypes via downregulating FEN1 to halt the cell cycle. | miR‑140‑5p inhibits cervical cancer cell phenotypes via downregulating FEN1 to halt the cell cycle.
Guo Y, Luo S. | 05/15/2021 |
| PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells. | PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells.
He L, Hu Z, Sun Y, Zhang M, Zhu H, Jiang L, Zhang Q, Mu D, Zhang J, Gu L, Yang Y, Pan FY, Jia S, Guo Z. | 04/17/2021 |
| Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma. | Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma.
Zhang Y, Liu X, Liu L, Chen J, Hu Q, Shen S, Zhou Y, Chen S, Xue C, Cui G, Yu Z., Free PMC Article | 04/3/2021 |
| Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation. | Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation.
Matsumoto Y, Brooks RC, Sverzhinsky A, Pascal JM, Tomkinson AE., Free PMC Article | 03/6/2021 |
| Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins. | Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins.
Hamza A, Driessen MRM, Tammpere E, O'Neil NJ, Hieter P., Free PMC Article | 01/23/2021 |
| Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability. | Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability.
Shi R, Wang Y, Gao Y, Xu X, Mao S, Xiao Y, Song S, Wang L, Tian B, Zhao Y, Hua Y, Xu H. | 12/19/2020 |
| Endonuclease FEN1 Coregulates ERalpha Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer. | Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer.
Flach KD, Periyasamy M, Jadhav A, Dorjsuren D, Siefert JC, Hickey TE, Opdam M, Patel H, Canisius S, Wilson DM 3rd, Donaldson Collier M, Prekovic S, Nieuwland M, Kluin RJC, Zakharov AV, Wesseling J, Wessels LFA, Linn SC, Tilley WD, Simeonov A, Ali S, Zwart W. | 10/31/2020 |