| Androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng. | Androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng.
Zhai W, Tian H, Liang X, Wu Y, Wen J, Liu Z, Zhao X, Tao L, Zou K., Free PMC Article | 10/20/2024 |
| Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis. | Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis.
Feng J, Xie L, Lu W, Yu X, Dong H, Ma Y, Kong R., Free PMC Article | 10/1/2024 |
| Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases. | Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases.
Chen ZL, Xie C, Zeng W, Huang RQ, Yang JE, Liu JY, Chen YJ, Zhuang SM., Free PMC Article | 08/8/2024 |
| Autophagy modulates the stability of Wee1 and cell cycle G2/M transition. | Autophagy modulates the stability of Wee1 and cell cycle G2/M transition.
Han B, Chen Y, Song C, Chen Y, Chen Y, Ferguson D, Yang Y, He A., Free PMC Article | 02/16/2024 |
| Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-gammaH2AX-MDC1. | Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1.
Zeng F, Peng Y, Qin Y, Wang J, Jiang G, Feng W, Yuan Y., Free PMC Article | 03/3/2023 |
| WEE1 promotes endometriosis via the Wnt/beta-catenin signaling pathway. | WEE1 promotes endometriosis via the Wnt/β-catenin signaling pathway.
Shi L, Xue X, Tian H, Ye H, Wang H, Wang R, Liu Y, Zhang C, Chen Q, Sun L., Free PMC Article | 03/5/2022 |
| WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway. | WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
Guo E, Xiao R, Wu Y, Lu F, Liu C, Yang B, Li X, Fu Y, Wang Z, Li Y, Huang Y, Li F, Wu X, You L, Qin T, Lu Y, Huang X, Ma D, Mills GB, Sun C, Chen G., Free PMC Article | 01/8/2022 |
| Morphine significantly downregulated the expression of miRNA-219-5p, which targets WEE1 to suppress Tyr15 expressions and activate Cdc2, thus inhibiting the morphine-induced macrophage apoptosis. | MicroRNA-219-5p Inhibits Morphine-Induced Apoptosis by Targeting Key Cell Cycle Regulator WEE1.
Lou W, Zhang X, Hu XY, Hu AR., Free PMC Article | 03/4/2017 |
| Results revealed that WEE1 is indispensable for maintaining genomic stability and it functions as a haploinsufficient tumor suppressor. | WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis.
Vassilopoulos A, Tominaga Y, Kim HS, Lahusen T, Li B, Yu H, Gius D, Deng CX., Free PMC Article | 08/8/2015 |
| Wee1 is directly or indirectly involved in the mechanism of the circadian rhythm-dependent changes in docetaxel-induced intestinal damage. | Involvement of Wee1 in the circadian rhythm-dependent intestinal damage induced by docetaxel.
Obi-Ioka Y, Ushijima K, Kusama M, Ishikawa-Kobayashi E, Fujimura A. | 11/30/2013 |
| The induction of Wee1 under hypoxia was confirmed both at the mRNA and protein levels. | Hypoxia induces Wee1 expression and attenuates hydrogen peroxide-induced endothelial damage in MS1 cells.
Hong KS, Kim HS, Kim SH, Lim DJ, Park JY, Kim SD., Free PMC Article | 05/5/2012 |
| In this study, we found that the chromosomal wee1 gene is also down-regulated by KLF3. | Mouse Wee1 gene is repressed by Krüppel-like factor 3 (KLF3) via interaction with multiple upstream elements.
Kitamura T, Suzuki H, Tamura TA. | 02/18/2012 |
| The regulation of Wee1 by SadA and SadB kinases is essential for the differentiation of polarized neurons. | Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.
Müller M, Lutter D, Püschel AW. | 03/8/2010 |
| Mammalian Wee1 plays a critical role in maintaining genome integrity and is essential for embryonic survival at the pre-implantation stage of mouse development. | Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development.
Tominaga Y, Li C, Wang RH, Deng CX., Free PMC Article | 03/1/2010 |
| the suppression of nuclear import of cyclin B1, the induction of Wee1 kinase activity, and the transient nuclear accumulation of p21(CIP1/WAF1) may play important roles in the transient cell cycle delay in response to ionizing radiation | Transient suppression of nuclear Cdc2 activity in response to ionizing radiation.
Kim MJ, Lee JY, Lee SJ. | 01/21/2010 |
| transcription repressive activity of TBP-related factor 2 to wee1 promoter needs association with the promoter and TFIIA | Transcriptional repression of the mouse wee1 gene by TBP-related factor 2.
Tanaka Y, Nanba YA, Park KA, Mabuchi T, Suenaga Y, Shiraishi S, Shimada M, Nakadai T, Tamura TA. | 01/21/2010 |
| expression of wee1 was directly regulated by the molecular components of the circadian clockwork in the regenerating liver | Control mechanism of the circadian clock for timing of cell division in vivo.
Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H. | 01/21/2010 |