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    FGF5 fibroblast growth factor 5 [ Homo sapiens (human) ]

    Gene ID: 2250, updated on 24-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Fibroblast growth factor 5 as a target for atrial fibrillation treatment: Evidence from mendelian randomization.

    Fibroblast growth factor 5 as a target for atrial fibrillation treatment: Evidence from mendelian randomization.
    Gao C, Wang W, Jia H.

    09/21/2024
    Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the Progression of Non-small Cell Lung Cancer via Upregulating the Level of FGF5.

    Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the Progression of Non-small Cell Lung Cancer via Upregulating the Level of FGF5.
    Zhang Q, Ding F, Zhang C, Han X, Cheng H.

    11/6/2023
    Improving the Efficiency of Precise Genome Editing with CRISPR/Cas9 to Generate Goats Overexpressing Human Butyrylcholinesterase.

    Improving the Efficiency of Precise Genome Editing with CRISPR/Cas9 to Generate Goats Overexpressing Human Butyrylcholinesterase.
    Wang JH, Wu SJ, Li Y, Zhao Y, Liu ZM, Deng SL, Lian ZX., Free PMC Article

    08/14/2023
    FGF5 protects heart from sepsis injury by attenuating cardiomyocyte pyroptosis through inhibiting CaMKII/NFkappaB signaling.

    FGF5 protects heart from sepsis injury by attenuating cardiomyocyte pyroptosis through inhibiting CaMKII/NFκB signaling.
    Cui S, Li Y, Zhang X, Wu B, Li M, Gao J, Xia H, Xu L.

    11/29/2022
    miR4913p functions as a tumor suppressor in nonsmall cell lung cancer by targeting fibroblast growth factor 5.

    miR‑491‑3p functions as a tumor suppressor in non‑small cell lung cancer by targeting fibroblast growth factor 5.
    Zhang G, Zheng H, Wang L., Free PMC Article

    07/30/2022
    Genetic susceptibility analysis of FGF5 polymorphism to preeclampsia in Chinese Han population.

    Genetic susceptibility analysis of FGF5 polymorphism to preeclampsia in Chinese Han population.
    Xin Q, Han Y, Jiang W, Wang J, Luan Y, Ji Q, Sun W.

    06/11/2022
    The rs1458038 variant near FGF5 is associated with poor response to calcium channel blockers among Filipinos.

    The rs1458038 variant near FGF5 is associated with poor response to calcium channel blockers among Filipinos.
    Punzalan FER, Cutiongco-de la Paz EMC, Nevado JJB, Magno JDA, Ona DID, Aman AYCL, Tiongson MDA, Llanes EJB, Reganit PFM, Tiongco RHP 2nd, Santos LEG, Aherrera JAM, Abrahan LL 4th, Agustin CF, Bejarin AJP, Sy RG., Free PMC Article

    02/19/2022
    Hsa_circ_0016760 exacerbates the malignant development of nonsmall cell lung cancer by sponging miR1455p/FGF5.

    Hsa_circ_0016760 exacerbates the malignant development of non‑small cell lung cancer by sponging miR‑145‑5p/FGF5.
    Zhu Z, Wu Q, Zhang M, Tong J, Zhong B, Yuan K., Free PMC Article

    11/22/2021
    High Expression of FGF5 Is an Independent Prognostic Factor for Poor Overall Survival and Relapse-Free Survival in Lung Adenocarcinoma.

    High Expression of FGF5 Is an Independent Prognostic Factor for Poor Overall Survival and Relapse-Free Survival in Lung Adenocarcinoma.
    Zhao T, Qian K, Zhang Y.

    09/18/2021
    Identifying Interactions between Dietary Sodium, Potassium, Sodium-Potassium Ratios, and FGF5 rs16998073 Variants and Their Associated Risk for Hypertension in Korean Adults.

    Identifying Interactions between Dietary Sodium, Potassium, Sodium-Potassium Ratios, and FGF5 rs16998073 Variants and Their Associated Risk for Hypertension in Korean Adults.
    Jeong H, Jin HS, Kim SS, Shin D., Free PMC Article

    05/15/2021
    FGF5 methylation is a sensitivity marker of esophageal squamous cell carcinoma to definitive chemoradiotherapy.

    FGF5 methylation is a sensitivity marker of esophageal squamous cell carcinoma to definitive chemoradiotherapy.
    Iwabu J, Yamashita S, Takeshima H, Kishino T, Takahashi T, Oda I, Koyanagi K, Igaki H, Tachimori Y, Daiko H, Nakazato H, Nishiyama K, Lee YC, Hanazaki K, Ushijima T., Free PMC Article

    10/31/2020
    FGF5, a growth factor that downregulated in SCOS Sertoli cells, could promote SSCs proliferation via ERK and AKT activation.

    Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation.
    Tian R, Yao C, Yang C, Zhu Z, Li C, Zhi E, Wang J, Li P, Chen H, Yuan Q, He Z, Li Z., Free PMC Article

    04/11/2020
    dual-luciferase reporter assay confirmed FGF5 as a target gene of miR-145-5p. FGF5 knockdown could partially reverse the protective effects of miR-145-5p on RGC-5 cells

    Downregulation of miR-145-5p elevates retinal ganglion cell survival to delay diabetic retinopathy progress by targeting FGF5.
    Zhang J, Cui C, Xu H.

    09/14/2019
    Study indicated that MTHFR rs1801133, FGF5 rs16998073 and CSK rs1378942 were associated with increased the risk of obesity in the Chinese children.

    Gene-gene interactions and associations of six hypertension related single nucleotide polymorphisms with obesity risk in a Chinese children population.
    Fu L, Zhang M, Hu YQ, Zhao X, Cheng H, Hou D, Mi J.

    10/27/2018
    FGF5 is an independent protective factor for breast cancer patients.

    Expression of Fibroblast Growth Factor 5 (FGF5) and Its Influence on Survival of Breast Cancer Patients.
    Huang Y, Wang H, Yang Y., Free PMC Article

    10/6/2018
    The results suggest that FGF2/rs1048201, FGF5/rs3733336 and FGF9/rs546782 are associated with the risk of non-syndromic orofacial cleft and that these miRNA-FGF interactions may affect non-syndromic orofacial cleft development.

    Associations between microRNA binding site SNPs in FGFs and FGFRs and the risk of non-syndromic orofacial cleft.
    Li D, Zhang H, Ma L, Han Y, Xu M, Wang Z, Jiang H, Zhang W, Wang L, Pan Y., Free PMC Article

    05/5/2018
    These results provide new insight into the functions of miR-9-3p and HBGF-5 in HCC and identify miR-9-3p as a potential therapeutic target for HCC

    Exosomal miR-9-3p suppresses HBGF-5 expression and is a functional biomarker in hepatocellular carcinoma.
    Tang J, Li Y, Liu K, Zhu Q, Yang WH, Xiong LK, Guo DL.

    02/3/2018
    FGF5 facilitates cell proliferation through ERK1/2 activation, and it influences the osteogenic differentiation of tonsil-derived mesenchymal stem cells.

    Role of Fibroblast Growth Factor-5 on the Proliferation of Human Tonsil-Derived Mesenchymal Stem Cells.
    Park GC, Song JS, Park HY, Shin SC, Jang JY, Lee JC, Wang SG, Lee BJ, Jung JS.

    09/16/2017
    These findings collectively demonstrate a tumor suppressor role of miR-188-5p in HCC progression via targeting FGF5

    MicroRNA-188-5p suppresses tumor cell proliferation and metastasis by directly targeting FGF5 in hepatocellular carcinoma.
    Fang F, Chang RM, Yu L, Lei X, Xiao S, Yang H, Yang LY.

    07/30/2016
    High BMI increases the effect of the blood pressure-increasing allele at rs1458038 near FGF5 in a Chinese population.

    Variant Near FGF5 Has Stronger Effects on Blood Pressure in Chinese With a Higher Body Mass Index.
    Li J, Shi J, Huang W, Sun J, Wu Y, Duan Q, Luo J, Lange LA, Gordon-Larsen P, Zheng SL, Yuan W, Wang Y, Popkin BM, Mo Z, Xu J, Du S, Mohlke KL, Lange EM., Free PMC Article

    04/9/2016
    In Chinese children, no association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension.

    Association of common variants in/near six genes (ATP2B1, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children.
    Xi B, Shen Y, Zhao X, Chandak GR, Cheng H, Hou D, Li Y, Ott J, Zhang Y, Wang X, Mi J.

    01/31/2015
    FGF5 is a crucial regulator of hair growth in humans.

    FGF5 is a crucial regulator of hair length in humans.
    Higgins CA, Petukhova L, Harel S, Ho YY, Drill E, Shapiro L, Wajid M, Christiano AM., Free PMC Article

    10/4/2014
    Meta-analysis indicated significant associations of both CYP17A1 rs11191548 and FGF5 rs16998073 polymorphisms with hypertension susceptibility in East Asians.

    Recapitulation of four hypertension susceptibility genes (CSK, CYP17A1, MTHFR, and FGF5) in East Asians.
    Xi B, Shen Y, Reilly KH, Wang X, Mi J.

    06/8/2013
    Variants in or near FGF5, CYP17A1 and MTHFR contributed to variation in BP and hypertension risk. Effect sizes of these three loci tended to be larger in Chinese than in white Europeans

    Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.
    Liu C, Li H, Qi Q, Lu L, Gan W, Loos RJ, Lin X.

    04/30/2011
    Observational study and meta-analysis of gene-disease association. (HuGE Navigator)

    Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study.
    Ho JE, Levy D, Rose L, Johnson AD, Ridker PM, Chasman DI., Free PMC Article

    12/5/2010
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