| Unveiling the Significance of FGF8 Overexpression in Orchestrating the Progression of Ovarian Cancer. | Unveiling the Significance of FGF8 Overexpression in Orchestrating the Progression of Ovarian Cancer.
Chandra KB, Kumar V, Ranjan S, Saini A, Tomar AK, Sharma JB, Mathur SR, Yadav S., Free PMC Article | 10/5/2023 |
| NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b. | NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b.
Hargittay B, Mineev KS, Richter C, Sreeramulu S, Jonker HRA, Saxena K, Schwalbe H., Free PMC Article | 06/5/2023 |
| FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex. | FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex.
Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y, Wang W., Free PMC Article | 09/25/2021 |
| Position effects at the FGF8 locus are associated with femoral hypoplasia. | Position effects at the FGF8 locus are associated with femoral hypoplasia.
Socha M, Sowińska-Seidler A, Melo US, Kragesteen BK, Franke M, Heinrich V, Schöpflin R, Nagel I, Gruchy N, Mundlos S, Sreenivasan VKA, López C, Vingron M, Bukowska-Olech E, Spielmann M, Jamsheer A., Free PMC Article | 09/18/2021 |
| Dissecting the Interaction of FGF8 with Receptor FGFRL1. | Dissecting the Interaction of FGF8 with Receptor FGFRL1.
Zhuang L, Vogel M, Villiger PM, Trueb B., Free PMC Article | 07/3/2021 |
| Mutations in fibroblast growth factor (FGF8) and FGF10 identified in patients with conotruncal defects. | Mutations in fibroblast growth factor (FGF8) and FGF10 identified in patients with conotruncal defects.
Zhou S, Wang Q, Meng Z, Peng J, Zhou Y, Song W, Wang J, Chen S, Sun K., Free PMC Article | 07/3/2021 |
| FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma. | FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma.
Hao Y, Xiao Y, Liao X, Tang S, Xie X, Liu R, Chen Q., Free PMC Article | 05/8/2021 |
| FGF8, FGF10 and FGF receptor 2 in foreskin of children with hypospadias: an analysis of immunohistochemical expression patterns and gene transcription. | FGF8, FGF10 and FGF receptor 2 in foreskin of children with hypospadias: an analysis of immunohistochemical expression patterns and gene transcription.
Haid B, Pechriggl E, Nägele F, Dudas J, Webersinke G, Rammer M, Fritsch H, Oswald J. | 03/6/2021 |
| The FGF8 is promising candidates for prognostic factors in adenocarcinomas of the esophago-gastric junction and new potential targets for new anti-cancer therapies. | Expression of FGF8, FGF18, and FGFR4 in Gastroesophageal Adenocarcinomas.
Jomrich G, Hudec X, Harpain F, Winkler D, Timelthaler G, Mohr T, Marian B, Schoppmann SF., Free PMC Article | 06/6/2020 |
| A missense mutation of FGF8 causing isiolated congenital anosmia is reported. | A novel FGF8 mutation in a female patient with isolated congenital anosmia.
Stamou MI, Plummer L, Koika V, Galli-Tsinopoulou A, Georgopoulos NA., Free PMC Article | 05/16/2020 |
| The first step is initiated either by the overactivation of the WNT canonical pathway or the suppression of the Bone Morphogenetic Protein (BMP) canonical pathway. This leads to an overexpression of Fibroblast Growth Factor 8 (FGF8) | A Review of the Genetics and Pathogenesis of Syndactyly in Humans and Experimental Animals: A 3-Step Pathway of Pathogenesis.
Al-Qattan MM., Free PMC Article | 02/29/2020 |
| proteome and qRT PCR data with regard to the future application and biological relevance of FGF8 in dental regenerative medicine. | Proteome response of dental pulp cells to exogenous FGF8.
Tsikandelova R, Mladenov P, Planchon S, Kalenderova S, Praskova M, Mihaylova Z, Stanimirov P, Mitev V, Renaut J, Ishkitiev N. | 10/19/2019 |
| we employ a sensitive assay of human FGF8 variants in zebrafish to demonstrate that the spectrum of isoforms of FGF8 produced by alternative splicing can provide key insights into the genetic susceptibility to human malformations | Loss-of-function mutations in FGF8 can be independent risk factors for holoprosencephaly.
Hong S, Hu P, Roessler E, Hu T, Muenke M., Free PMC Article | 02/16/2019 |
| results of this study suggest that FGF8 and Survivin contribute to radiation resistance in rectal cancer and may serve as markers to select patients who may not benefit from neoadjuvant radiotherapy | FGF8 induces therapy resistance in neoadjuvantly radiated rectal cancer.
Harpain F, Ahmed MA, Hudec X, Timelthaler G, Jomrich G, Müllauer L, Selzer E, Dörr W, Bergmann M, Holzmann K, Grasl-Kraupp B, Grusch M, Berger W, Marian B, Silberhumer GR., Free PMC Article | 02/2/2019 |
| The expression of BMP4 and FGF8 corelates well with the proliferative component of the pathologies, indicating a possible role in the pathogenesis and progression of Odontogenic Cyst and Tumors. | Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors.
Swarup N, Nayak MT, Chowdhary Z, Mehendiratta M, Khatana S, Choi SJ, Sagolsem C., Free PMC Article | 10/27/2018 |
| Study demonstrated that FGF8 can regulate germ cell fate by modulating the dynamic equilibrium between differentiation and self-renewal. | Regulation of fibroblast growth factor 8 (FGF8) in chicken embryonic stem cells differentiation into spermatogonial stem cells.
Wang M, Zhang C, Huang C, Cheng S, He N, Wang Y, Ahmed MF, Zhao R, Jin J, Zuo Q, Zhang Y, Li B. | 10/20/2018 |
| FGF8 and FGFR3 may therefore play an important role in the onset of deep zone necrosis and pathogenesis in Kashin-Beck disease in adolescent children. | FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease.
Liu H, Fang Q, Wang M, Wang W, Zhang M, Zhang D, He Y, Zhang Y, Wang H, Otero M, Ma T, Chen J. | 09/22/2018 |
| we also found that FGF8 increased the expression of YAP1 and knockdown of YAP1 eliminated the upregulation of EGFR and the resistance to EGFR inhibition induced by FGF8. Our study provides evidence that FGF8 plays an important role in the resistance to EGFR inhibition of human hepatocellular carcinoma cells | FGF8 promotes cell proliferation and resistance to EGFR inhibitors via upregulation of EGFR in human hepatocellular carcinoma cells.
Pei Y, Sun X, Guo X, Yin H, Wang L, Tian F, Jing H, Liang X, Xu J, Shi P. | 05/12/2018 |
| Genetic testing identified a de novo, heterozygous mutation in fibroblast growth factor receptor 1 (FGFR1 p.L630P). L630 resides on the ATP binding cleft of the FGFR1 tyrosine kinase domain, and L630P is predicted to cause a complete loss of receptor function. Cell-based assays confirmed that L630P abolishes FGF8 signaling activity | Genetic testing facilitates prepubertal diagnosis of congenital hypogonadotropic hypogonadism.
Xu C, Lang-Muritano M, Phan-Hug F, Dwyer AA, Sykiotis GP, Cassatella D, Acierno J Jr, Mohammadi M, Pitteloud N., Free PMC Article | 04/21/2018 |
| Bonferroni adjusted p-value: 0.04). No statistically significant associations were identified in the other ethnic groups. In conclusion, variant/s in FGF2 and FGF8 may predispose diabetics with CKD to LEA. | Variants in genes belonging to the fibroblast growth factor family are associated with lower extremity amputation in non-Hispanic whites: Findings from the chronic renal insufficiency cohort study.
Gupta J, Mitra N, Townsend RR, Fischer M, Schelling JR, Margolis DJ., Free PMC Article | 04/7/2018 |
| in one holoprosencephaly (HPE) family, a deleterious FGFR1 allele was transmitted from one parent and a loss-of-function allele in FGF8 from the other parent to both affected daughters. This family is one of the clearest examples to date of gene:gene synergistic interactions causing HPE in humans. | Dominant-negative kinase domain mutations in FGFR1 can explain the clinical severity of Hartsfield syndrome.
Hong S, Hu P, Marino J, Hufnagel SB, Hopkin RJ, Toromanović A, Richieri-Costa A, Ribeiro-Bicudo LA, Kruszka P, Roessler E, Muenke M., Free PMC Article | 07/29/2017 |
| The FBLN1/FGF8 interaction may also be involved in the survival of neural crest cell population during development. | Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: EFFECTS ON EMBRYO SURVIVAL.
Fresco VM, Kern CB, Mohammadi M, Twal WO., Free PMC Article | 05/20/2017 |
| Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed. | Fgf8 signaling for development of the midbrain and hindbrain.
Harada H, Sato T, Nakamura H. | 02/18/2017 |
| Regulation of neurogenesis by Fgf8a requires Cdc42 signaling and a novel Cdc42 effector protein | Regulation of neurogenesis by Fgf8a requires Cdc42 signaling and a novel Cdc42 effector protein.
Hulstrand AM, Houston DW., Free PMC Article | 09/21/2016 |
| Our results link FGF8, c-Abl and p300 in a regulatory pathway that controls DeltaNp63alpha protein stability and transcriptional activity. | FGF8, c-Abl and p300 participate in a pathway that controls stability and function of the ΔNp63α protein.
Restelli M, Molinari E, Marinari B, Conte D, Gnesutta N, Costanzo A, Merlo GR, Guerrini L., Free PMC Article | 05/21/2016 |