| Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers. | Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers.
Shani S, Goldstein O, Gana-Weisz M, Bar-Shira A, Thaler A, Gurevich T, Mirelman A, Giladi N, Alcalay RN, Orr-Urtreger A. | 06/15/2023 |
| A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr. | A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr.
Perez I, Berndt S, Agarwal R, Castro MA, Vishnivetskiy SA, Smith JC, Sanders CR, Gurevich VV, Iverson TM., Free PMC Article | 02/5/2022 |
| These studies show that Hck and Fgr expression influences inhibitor sensitivity and the pathway to acquired resistance in Flt3-ITD+ AML. | Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance.
Patel RK, Weir MC, Shen K, Snyder D, Cooper VS, Smithgall TE., Free PMC Article | 03/28/2020 |
| Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation | The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.
Shen K, Moroco JA, Patel RK, Shi H, Engen JR, Dorman HR, Smithgall TE. | 12/21/2019 |
| Fgr protein is overexpressed in acute myelogenous leukemia. | Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo.
Weir MC, Shu ST, Patel RK, Hellwig S, Chen L, Tan L, Gray NS, Smithgall TE., Free PMC Article | 04/20/2019 |
| Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer yielded PTAFR and FGR as the most important hub genes for predicting patient survival. | Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer.
Zhang C, Sun Q. | 03/17/2018 |
| the Src tyrosine kinase Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR) is associated with suberoylanilide hydroxamic acid resistance. | A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.
Joosten M, Ginzel S, Blex C, Schmidt D, Gombert M, Chen C, Linka RM, Gräbner O, Hain A, Hirsch B, Sommerfeld A, Seegebarth A, Gruber U, Maneck C, Zhang L, Stenin K, Dieks H, Sefkow M, Münk C, Baldus CD, Thiele R, Borkhardt A, Hummel M, Köster H, Fischer U, Dreger M, Seitz V., Free PMC Article | 11/4/2017 |
| we provide evidence for involvement of HCK and FGR in FCRL4-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 molecule. | Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.
Liu Y, Bezverbnaya K, Zhao T, Parsons MJ, Shi M, Treanor B, Ehrhardt GR., Free PMC Article | 08/22/2015 |
| Data indicate that combined treatment using SFK (LYN, HCK, or FGR) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 activity and enhancing targeting of acute myeloid leukemia (AML) stem cells. | The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.
Dos Santos C, McDonald T, Ho YW, Liu H, Lin A, Forman SJ, Kuo YH, Bhatia R., Free PMC Article | 11/16/2013 |
| Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target | Functional roles of Src and Fgr in ovarian carcinoma.
Kim HS, Han HD, Armaiz-Pena GN, Stone RL, Nam EJ, Lee JW, Shahzad MM, Nick AM, Lee SJ, Roh JW, Nishimura M, Mangala LS, Bottsford-Miller J, Gallick GE, Lopez-Berestein G, Sood AK., Free PMC Article | 07/23/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LAC, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S. | 06/30/2010 |
| Recruitment of the coactivator, SRC2, is coupled to cooperative DNA binding by the progesterone receptor. | Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptor.
Heneghan AF, Connaghan-Jones KD, Miura MT, Bain DL. | 01/21/2010 |
| Substitution of two relevant serines with glutamic acid residues in urokinase prevents urokinase activation of p55fgr needed for cell migration and adhesion. | Inhibition of receptor-dependent urokinase signaling by specific Ser to Glu substitutions.
Carriero MV, Franco P, Gargiulo L, Vocca I, Cito L, Fontana L, Iaccarino C, Del Pozzo G, Guardiola J, Stoppelli MP. | 01/21/2010 |