| Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer. | Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer.
Chen X, Yu Y, Su Y, Shi L, Xie S, Hong Y, Liu X, Yin F. | 03/12/2024 |
| Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity. | Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.
Luo Q, Pan Y, Fu Q, Zhang X, Zhou S, Yu P, Tian H, Liu P, Chen S, Zhang H, Qin T., Free PMC Article | 10/8/2023 |
| Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients. | Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients.
Lin Y, Ban R, Qiao L, Chen J, Liu M, Liu J, Shi Q. | 07/3/2023 |
| Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells. | Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells.
van Essen MF, Peereboom ETM, Schlagwein N, van Gijlswijk-Janssen DJ, Nelemans T, Joeloemsingh JV, van den Berg CW, Prins J, Clark SJ, Schmidt CQ, Trouw LA, van Kooten C. | 06/22/2023 |
| FHL1 as a novel prognostic biomarker and correlation with immune infiltration levels in lung adenocarcinoma. | FHL1 as a novel prognostic biomarker and correlation with immune infiltration levels in lung adenocarcinoma.
Zhang J, Li H, Guo M, Zhang J, Zhang G, Sun N, Feng Y, Cui W, Xu F. | 02/24/2023 |
| Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells. | Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells.
Liu Y, Li H, Zhao Y, Li D, Zhang Q, Fu J, Fan S. | 09/24/2022 |
| MiR-96-5p Facilitates Lung Adenocarcinoma Cell Phenotypes by Inhibiting FHL1. | MiR-96-5p Facilitates Lung Adenocarcinoma Cell Phenotypes by Inhibiting FHL1.
Zhou F, Qian C, Chen T, Zang X., Free PMC Article | 09/3/2022 |
| Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation. | Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.
Eshibona N, Giwa A, Rossouw SC, Gamieldien J, Christoffels A, Bendou H. | 08/27/2022 |
| Three novel FHL1 variants cause a mild phenotype of Emery-Dreifuss muscular dystrophy. | Three novel FHL1 variants cause a mild phenotype of Emery-Dreifuss muscular dystrophy.
Borch JDS, Krag T, Holm-Yildiz SD, Cetin H, Solheim TA, Fornander F, Straub V, Duno M, Vissing J., Free PMC Article | 08/13/2022 |
| A Dominant C150Y Mutation in FHL1 Induces Structural Alterations in LIM2 Domain Causing Protein Aggregation In Human and Drosophila Indirect Flight Muscles. | A Dominant C150Y Mutation in FHL1 Induces Structural Alterations in LIM2 Domain Causing Protein Aggregation In Human and Drosophila Indirect Flight Muscles.
Santhoshkumar R, Preethish-Kumar V, Mangalaparthi KK, Unni S, Padmanabhan B, T S KP, Nongthomba U, Atchayaram N, Narayanappa G. | 02/26/2022 |
| FHL1 promotes glioblastoma aggressiveness through regulating EGFR expression. | FHL1 promotes glioblastoma aggressiveness through regulating EGFR expression.
Sun L, Chen L, Zhu H, Li Y, Chen CC, Li M. | 07/10/2021 |
| Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein. | Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.
Lukash T, Agback T, Dominguez F, Shiliaev N, Meshram C, Frolova EI, Agback P, Frolov I., Free PMC Article | 03/20/2021 |
| results suggest that FHL1A specifically interacts with PLEKHG2 to regulate a function of PLEKHG2 that is modified by the interaction of Gbetagamma and Galphas. | Specific activation of PLEKHG2-induced serum response element-dependent gene transcription by four-and-a-half LIM domains (FHL) 1, but not FHL2 or FHL3.
Nishikawa M, Sato K, Nakano S, Yamakawa H, Nagase T, Ueda H., Free PMC Article | 04/11/2020 |
| FHL1-related clinical, muscle MRI and genetic features in six Chinese patients with reducing body myopathy. | FHL1-related clinical, muscle MRI and genetic features in six Chinese patients with reducing body myopathy.
Hu Z, Zhu Y, Liu X, Zhang W, Liu J, Wu S, Xiao J, Yuan Y, Wang Z. | 12/28/2019 |
| study shows that FHL1 is a key factor expressed by the host that enables chikungunya virus (CHIKV) infection and identifies the interaction between nsP3 and FHL1 as a promising target for the development of anti-CHIKV therapies | FHL1 is a major host factor for chikungunya virus infection.
Meertens L, Hafirassou ML, Couderc T, Bonnet-Madin L, Kril V, Kümmerer BM, Labeau A, Brugier A, Simon-Loriere E, Burlaud-Gaillard J, Doyen C, Pezzi L, Goupil T, Rafasse S, Vidalain PO, Bertrand-Legout A, Gueneau L, Juntas-Morales R, Ben Yaou R, Bonne G, de Lamballerie X, Benkirane M, Roingeard P, Delaugerre C, Lecuit M, Amara A. | 11/30/2019 |
| This study revealed that miR-483-3p derived from IGF2 was associated with Hirschsprung's disease by targeting FHL1 and may provide a new pathway to understand the aetiology of Hirschsprung's disease. | IGF2-derived miR-483-3p associated with Hirschsprung's disease by targeting FHL1.
Zhi Z, Zhu H, Lv X, Lu C, Li Y, Wu F, Zhou L, Li H, Tang W., Free PMC Article | 11/23/2019 |
| Based on bioinformatic analysis, MMP1 and FHL1 are potentially functional proteins associated with differences of highly-metastatic prostate cancer PC-3M-1E8 cell line and poorly-metastatic PC-3M-2B4 cell line. | Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential.
Zhang S, Zheng C, Yao S, Wang Z, Xu L, Yang R, Meng X, Wu J, Zhou L, Sun Z., Free PMC Article | 03/30/2019 |
| FHL1 can either suppress or promote tumor cell growth depending on the status of the sites for phosphorylation by Src. | Src-mediated phosphorylation converts FHL1 from tumor suppressor to tumor promoter.
Wang X, Wei X, Yuan Y, Sun Q, Zhan J, Zhang J, Tang Y, Li F, Ding L, Ye Q, Zhang H., Free PMC Article | 03/23/2019 |
| FHL1 increase inhibitory CDC25 phosphorylation by forming a complex with CHK2 and CDC25, and sequester CDC25 in the cytoplasm by forming another complex with 14-3-3 and CDC25, resulting in increased radioresistance in cancer cells. | A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.
Xu X, Fan Z, Liang C, Li L, Wang L, Liang Y, Wu J, Chang S, Yan Z, Lv Z, Fu J, Liu Y, Jin S, Wang T, Hong T, Dong Y, Ding L, Cheng L, Liu R, Fu S, Jiao S, Ye Q., Free PMC Article | 11/17/2018 |
| FHL1 promote paclitaxel resistance in hepatocellular carcinomas cells through regulating apoptosis induced by paclitaxel, suggesting that FHL1 may be a promising molecular target for Hepatocellular carcinoma therapy. | Four-and-a-half LIM protein 1 promotes paclitaxel resistance in hepatic carcinoma cells through the regulation of caspase-3 activation.
Zhou L, Ding L, Liu J, Zhang Y, Luo X, Zhao L, Ren J. | 11/3/2018 |
| Altogether, the specific localization of FHL1B and its modulation in disease-patient's myoblasts confirmed FHL1-related Emery-Dreifuss muscular dystrophy as a nuclear envelope disease. | FHL1B Interacts with Lamin A/C and Emerin at the Nuclear Lamina and is Misregulated in Emery-Dreifuss Muscular Dystrophy.
Ziat E, Mamchaoui K, Beuvin M, Nelson I, Azibani F, Spuler S, Bonne G, Bertrand AT. | 03/17/2018 |
| Low FHL1 expression is associated with head and neck squamous cell carcinoma. | X-linked FHL1 as a novel therapeutic target for head and neck squamous cell carcinoma.
Cao W, Liu J, Xia R, Lin L, Wang X, Xiao M, Zhang C, Li J, Ji T, Chen W., Free PMC Article | 01/6/2018 |
| We have uncovered FHL1 as a novel potential regulator of calcium homeostasis in both fish and humans and have implicated it in isolated hypoparathyroidism. | A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism.
Pillar N, Pleniceanu O, Fang M, Ziv L, Lahav E, Botchan S, Cheng L, Dekel B, Shomron N., Free PMC Article | 08/19/2017 |
| Mutations in FHL1 cause unclassifiable cardiomyopathy with coexisting Emery-Dreifuss muscular dystrophy. | Unclassifiable arrhythmic cardiomyopathy associated with Emery-Dreifuss caused by a mutation in FHL1.
San Román I, Navarro M, Martínez F, Albert L, Polo L, Guardiola J, García-Molina E, Muñoz-Esparza C, López-Ayala JM, Sabater-Molina M, Gimeno JR. | 05/27/2017 |
| results provide evidence that FHL1A interacts with PLEKHG2 and regulates cell morphological change through the activity of PLEKHG2. | Four-and-a-half LIM Domains 1 (FHL1) Protein Interacts with the Rho Guanine Nucleotide Exchange Factor PLEKHG2/FLJ00018 and Regulates Cell Morphogenesis.
Sato K, Kimura M, Sugiyama K, Nishikawa M, Okano Y, Nagaoka H, Nagase T, Kitade Y, Ueda H., Free PMC Article | 05/27/2017 |