| Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals. | Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals.
Herr LA, Fiala GJ, Sagar, Schaffer AM, Hummel JF, Zintchenko M, Raute K, Velasco Cárdenas RM, Heizmann B, Ebert K, Fehrenbach K, Janowska I, Chan S, Tanriver Y, Minguet S, Schamel WW., Free PMC Article | 03/20/2024 |
| Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos. | Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing Actions of the Related Transcription Factors Eos and Aiolos.
Jones DM, Tuazon JA, Read KA, Leonard MR, Pokhrel S, Sreekumar BK, Warren RT, Yount JS, Collins PL, Oestreich KJ., | 03/20/2024 |
| IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression. | IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression.
Rodrigues de Oliveira B, Iansavitchous J, Rysan H, Wang WC, Sams MP, Knight D, Xu LS, Jeong J, Qu TP, Zorzi AP, DeKoter RP. | 02/4/2024 |
| The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes. | The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes.
Yomogida K, Trsan T, Sudan R, Rodrigues PF, Ulezko Antonova A, Ingle H, Luccia BD, Collins PL, Cella M, Gilfillan S, Baldridge MT, Oltz EM, Colonna M. | 01/9/2024 |
| Impaired tissue homing by the Ikzf3[N159S] variant is mediated by interfering with Ikaros function. | Impaired tissue homing by the Ikzf3(N159S) variant is mediated by interfering with Ikaros function.
Chang J, Yamashita M, Padhi AK, Zhang KYJ, Taniuchi I., Free PMC Article | 09/27/2023 |
| Aiolos represses CD4[+] T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity. | Aiolos represses CD4(+) T cell cytotoxic programming via reciprocal regulation of T(FH) transcription factors and IL-2 sensitivity.
Read KA, Jones DM, Pokhrel S, Hales EDS, Varkey A, Tuazon JA, Eisele CD, Abdouni O, Saadey A, Leonard MR, Warren RT, Powell MD, Boss JM, Hemann EA, Yount JS, Xin G, Ghoneim HE, Lio CJ, Freud AG, Collins PL, Oestreich KJ., Free PMC Article | 03/28/2023 |
| IKZF3 modulates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation. | IKZF3 modulates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation.
Meng C, Chen S, He Q, Tan J, Wu J, Zhao J. | 01/14/2023 |
| AIOLOS Variants Causing Immunodeficiency in Human and Mice. | AIOLOS Variants Causing Immunodeficiency in Human and Mice.
Yamashita M, Morio T., Free PMC Article | 04/30/2022 |
| Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity. | Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity.
Qiu J, Zhang J, Ji Y, Sun H, Gu Z, Sun Q, Bai M, Gong J, Tang J, Zhang Y, Li S, Shao Z, Li J, Sheng H, Shen L, Qiu J., Free PMC Article | 03/19/2022 |
| Aiolos regulates eosinophil migration into tissues. | Aiolos regulates eosinophil migration into tissues.
Felton JM, Bouffi C, Schwartz JT, Schollaert KL, Malik A, Vallabh S, Wronowski B, Magier AZ, Merlin L, Barski A, Weirauch MT, Fulkerson PC, Rothenberg ME., Free PMC Article | 03/19/2022 |
| T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients. | T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients.
Kuehn HS, Chang J, Yamashita M, Niemela JE, Zou C, Okuyama K, Harada J, Stoddard JL, Nunes-Santos CJ, Boast B, Baxter RM, Hsieh EWY, Garofalo M, Fleisher TA, Morio T, Taniuchi I, Dutmer CM, Rosenzweig SD., Free PMC Article | 01/1/2022 |
| These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function. | Peripheral natural killer cell maturation depends on the transcription factor Aiolos.
Holmes ML, Huntington ND, Thong RP, Brady J, Hayakawa Y, Andoniou CE, Fleming P, Shi W, Smyth GK, Degli-Esposti MA, Belz GT, Kallies A, Carotta S, Smyth MJ, Nutt SL., Free PMC Article | 02/14/2015 |
| study demonstrated that Aiolos silenced the Il2 locus, promoting TH17 differentiation in vitro and in vivo | Aiolos promotes TH17 differentiation by directly silencing Il2 expression.
Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK., Free PMC Article | 10/13/2012 |
| Aiolos and Ikaros bind to the c-myc promoter in vivo and directly suppress c-myc expression in pre-B cells. | Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression.
Ma S, Pathak S, Mandal M, Trinh L, Clark MR, Lu R., Free PMC Article | 09/20/2010 |
| Aiolos knockout mice develop the symptoms of human systemic lupus erythematosus (SLE). This finding implicates Aiolos as a possible candidate gene for SLE. | Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice.
Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P, Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P. | 05/20/2010 |
| A novel role for OBF-1 and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR function. | Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1.
Karnowski A, Cao C, Matthias G, Carotta S, Corcoran LM, Martensson IL, Skok JA, Matthias P., Free PMC Article | 01/21/2010 |
| Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations. | Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity.
Cortés M, Georgopoulos K., Free PMC Article | 01/21/2010 |
| A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4-deprived cells via association to the transcription factor Aiolos. | The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis.
Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A. | 01/21/2010 |
| Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus. | Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice.
Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P, Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P. | 01/21/2010 |