| HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR inhibitors through the ETS1-FKBP12 axis. | HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR inhibitors through the ETS1-FKBP12 axis.
Guo JR, He KY, Yuan JL, An W, Yin WT, Li QT, Lu LY, Yang JY, Liu MJ, Li YJ, Zhao Y, Yang Q, Lei XY, Gao F, Zhang L, Wu DH, Li JQ, Zhao ZL, Liu H, Zhu LJ, Xiang XY, Sun QH, Jian YP, Xu ZX., Free PMC Article | 06/13/2024 |
| The high FKBP1A expression in WBCs as a potential screening biomarker for pancreatic cancer. | The high FKBP1A expression in WBCs as a potential screening biomarker for pancreatic cancer.
Watcharanurak P, Mutirangura A, Aksornkitti V, Bhummaphan N, Puttipanyalears C., Free PMC Article | 04/8/2024 |
| Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits Osteosarcoma Progression. | Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits Osteosarcoma Progression.
Yang X, Sun P. | 08/30/2023 |
| Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via Apoptosis Pathway. | Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via Apoptosis Pathway.
Cai S, Chen Z, Tang H, Meng S, Tao L, Wang Q., Free PMC Article | 12/31/2022 |
| The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma. | The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma.
Li Z, Cui Y, Duan Q, Zhang J, Shao D, Cao X, Gao Y, Wang S, Li J, Jones OD, Lei X, Wang L, Zhou X, Xu M, Ma J, Liu Y, Xu X., Free PMC Article | 11/19/2022 |
| FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC. | FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC.
Patel D, Dabhi AM, Dmello C, Seervi M, Sneha KM, Agrawal P, Sahani MH, Kanojia D. | 04/16/2022 |
| FKBP51 promotes invasion and migration by increasing the autophagic degradation of TIMP3 in clear cell renal cell carcinoma. | FKBP51 promotes invasion and migration by increasing the autophagic degradation of TIMP3 in clear cell renal cell carcinoma.
Mao S, Zhang D, Chen L, Tan J, Chu Y, Huang S, Zhou W, Qin H, Xia Q, Zhao Y, Li R, Qin S, Wei M., Free PMC Article | 02/5/2022 |
| CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis. | CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis.
Wang G, Zhao H, Duan X, Ren Z. | 11/22/2021 |
| Regulation of the Ca(2+)-activated chloride channel Anoctamin-1 (TMEM16A) by Ca(2+)-induced interaction with FKBP12 and calcineurin. | Regulation of the Ca(2+)-activated chloride channel Anoctamin-1 (TMEM16A) by Ca(2+)-induced interaction with FKBP12 and calcineurin.
Sánchez-Solano A, Corral N, Segura-Covarrubias G, Guzmán-Hernández ML, Arechiga-Figueroa I, Cruz-Rangel S, Pérez-Cornejo P, Arreola J. | 08/7/2021 |
| Study discovered that FKBP12 is essential for initiating necrosome formation and RIPK1-RIPK3-MLKL signaling pathway activation in response to TNF receptor 1 ligation. In addition, FKBP12 is indispensable for RIPK1 and RIPK3 expression and subsequent spontaneous phosphorylation, which are essential processes for initial necrosome formation and necroptotic signal transduction. | FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
Wang Z, Feng J, Yu J, Chen G. | 07/25/2020 |
| Results found that FKBP1A is post-transcriptional regulated in prostate neoplasm cells regulated after miR-388 is sponged in the cytoplasm by SNHG15. | LncRNA SNHG15 acts as an oncogene in prostate cancer by regulating miR-338-3p/FKBP1A axis.
Zhang Y, Zhang D, Lv J, Wang S, Zhang Q. | 06/15/2019 |
| FKBP1A rs6041749 C allele carriers are at higher risk for eGFR deterioration in renal transplant patients; the variant might serve as a biomarker to predict allograft function in renal transplant patients | FKBP1A rs6041749 polymorphism is associated with allograft function in renal transplant patients.
Wu Z, Xu Q, Qiu X, Xu L, Jiao Z, Zhang M, Zhong M. | 04/6/2019 |
| this study examined the effect of the suppressor FKBP12 on the signal transduction of a further 14 ALK2 mutations associated with fibrodysplasia ossificans progressiva or diffuse intrinsic pontine glioma. | Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders.
Machiya A, Tsukamoto S, Ohte S, Kuratani M, Fujimoto M, Kumagai K, Osawa K, Suda N, Bullock AN, Katagiri T. | 03/23/2019 |
| These findings of this study suggested that FKBP12 is linked to the accumulation of alpha-SYN and phosphorylated tau protein in alpha-synucleinopathies. FKBP12 may play important roles in the pathogenesis of alpha-synucleinopathies. | FKBP12-immunopositive inclusions in patients with α-synucleinopathies.
Honjo Y, Ayaki T, Horibe T, Ito H, Takahashi R, Kawakami K. | 08/18/2018 |
| ubiquitylation destabilizes the fold of two proteins, FKBP12 and FABP4 | Ubiquitylation Directly Induces Fold Destabilization of Proteins.
Morimoto D, Walinda E, Fukada H, Sugase K, Shirakawa M., Free PMC Article | 07/28/2018 |
| FKBP12 binding is required for full Met activation and everolimus can inhibit Met | Everolimus induces Met inactivation by disrupting the FKBP12/Met complex.
Raimondo L, D'Amato V, Servetto A, Rosa R, Marciano R, Formisano L, Di Mauro C, Orsini RC, Cascetta P, Ciciola P, De Maio AP, Di Renzo MF, Cosconati S, Bruno A, Randazzo A, Napolitano F, Montuori N, Veneziani BM, De Placido S, Bianco R., Free PMC Article | 01/20/2018 |
| Specifically tested on two model systems, the power of iSPOT is demonstrated to accurately predict the structures of a large protein-protein complex (TGFbeta-FKBP12) and a multidomain nuclear receptor homodimer (HNF-4alpha), based on the structures of individual components of the complexes. | Theoretical modeling of multiprotein complexes by iSPOT: Integration of small-angle X-ray scattering, hydroxyl radical footprinting, and computational docking.
Huang W, Ravikumar KM, Parisien M, Yang S., Free PMC Article | 12/23/2017 |
| These results identify a novel function for FKBP12 in downregulating MDM2, which directly enhances sensitivity of cancer cells to chemotherapy and nutlin-3 treatment. | FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2.
Liu T, Xiong J, Yi S, Zhang H, Zhou S, Gu L, Zhou M., Free PMC Article | 09/2/2017 |
| Data show that FKBP12 (FK506 binding protein 1A)conformational transition Is coupled to histidine tautomerization. | Dynamics of Aromatic Side Chains in the Active Site of FKBP12.
Weininger U, Modig K, Geitner AJ, Schmidpeter PA, Koch JR, Akke M. | 05/27/2017 |
| Electrostatic effects on the folding stability of FKBP12 | Electrostatic effects on the folding stability of FKBP12.
Batra J, Tjong H, Zhou HX., Free PMC Article | 05/7/2017 |
| Findings indicate that mutant huntingtin (mHTT) aggregates can be transformed into benign species by isomerase FKBP12. | Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect.
Sun CS, Lee CC, Li YN, Yao-Chen Yang S, Lin CH, Chang YC, Liu PF, He RY, Wang CH, Chen W, Chern Y, Jen-Tse Huang J., Free PMC Article | 08/20/2016 |
| How phosphorylation of RyR affects channel activity and whether proteins such as the FK-506 binding proteins (FKBP12 and FKBP12.6) are involved in heart failure | The ryanodine receptor provides high throughput Ca2+-release but is precisely regulated by networks of associated proteins: a focus on proteins relevant to phosphorylation.
O'Brien F, Venturi E, Sitsapesan R. | 02/27/2016 |
| RyRs have been identified as important targets of FKBP12 and FKBP12.6, members of the immunophilin family | Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulation.
Vervliet T, Parys JB, Bultynck G. | 02/27/2016 |
| Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11betaHSD1. | UFSRAT: Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11βHSD1.
Shave S, Blackburn EA, Adie J, Houston DR, Auer M, Webster SP, Taylor P, Walkinshaw MD., Free PMC Article | 01/16/2016 |
| Selectivity within the FKBP family, in particular selective inhibition of FKBP12 or FKBP51, is possible. FKBP51 is a pharmacologically tractable target for stress-related disorders. | FKBPs and their role in neuronal signaling.
Hausch F. | 11/14/2015 |