| The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy. | The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy.
Xu WN, Zheng HL, Yang RZ, Sun YF, Peng BR, Liu C, Song J, Jiang SD, Zhu LX., Free PMC Article | 03/15/2024 |
| ATF5 promotes malignant T cell survival through the PI3K/AKT/mTOR pathway in cutaneous T cell lymphoma. | ATF5 promotes malignant T cell survival through the PI3K/AKT/mTOR pathway in cutaneous T cell lymphoma.
Cao M, Lai P, Liu X, Liu F, Qin Y, Tu P, Wang Y., Free PMC Article | 02/15/2024 |
| Activating Transcription Factor 5 Promotes Neuroblastoma Metastasis by Inducing Anoikis Resistance. | Activating Transcription Factor 5 Promotes Neuroblastoma Metastasis by Inducing Anoikis Resistance.
Banerjee D, Boboila S, Okochi S, Angelastro JM, Kadenhe-Chiweshe AV, Lopez G, Califano A, Connolly EP, Greene LA, Yamashiro DJ., Free PMC Article | 12/21/2023 |
| ATF5 Attenuates Apoptosis in Hippocampal Neurons with Seizures Evoked by Mg[2+]-Free Medium via Regulating Mitochondrial Unfolded Protein Response. | ATF5 Attenuates Apoptosis in Hippocampal Neurons with Seizures Evoked by Mg(2+)-Free Medium via Regulating Mitochondrial Unfolded Protein Response.
Wang X, Yu X, Li Y, Liu F, Du L, Xie N, Wang C. | 01/28/2023 |
| ATF5 and HIF1alpha cooperatively activate HIF1 signaling pathway in esophageal cancer. | ATF5 and HIF1α cooperatively activate HIF1 signaling pathway in esophageal cancer.
He F, Xiao H, Cai Y, Zhang N., Free PMC Article | 01/29/2022 |
| Influence of genetic variants in asparaginase pathway on the susceptibility to asparaginase-related toxicity and patients' outcome in childhood acute lymphoblastic leukemia. | Influence of genetic variants in asparaginase pathway on the susceptibility to asparaginase-related toxicity and patients' outcome in childhood acute lymphoblastic leukemia.
Youssef YH, Makkeyah SM, Soliman AF, Meky NH. | 11/13/2021 |
| Human Cytomegalovirus Infection Activates Glioma Activating Transcription Factor 5 via microRNA in a Stress-Induced Manner. | Human Cytomegalovirus Infection Activates Glioma Activating Transcription Factor 5 via microRNA in a Stress-Induced Manner.
Hu M, Yu B, Zhang B, Wang B, Qian D, Li H, Ma J, Liu DX. | 11/6/2021 |
| ATF5, a putative therapeutic target for the mitochondrial DNA 3243A > G mutation-related disease. | ATF5, a putative therapeutic target for the mitochondrial DNA 3243A > G mutation-related disease.
Gao X, Jiang Z, Yan X, Liu J, Li F, Liu P, Li J, Wei Y, Sun YE, Zhang Y, Wang C., Free PMC Article | 09/25/2021 |
| Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to rapamycin-induced radio-sensitivity in lung cancer cell line A549. | Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to rapamycin-induced radio-sensitivity in lung cancer cell line A549.
Lai C, Zhang J, Tan Z, Shen LF, Zhou RR, Zhang YY., Free PMC Article | 07/24/2021 |
| ATF5 involved in radioresistance in nasopharyngeal carcinoma by promoting epithelial-to-mesenchymal phenotype transition. | ATF5 involved in radioresistance in nasopharyngeal carcinoma by promoting epithelial-to-mesenchymal phenotype transition.
Shuai Y, Fan E, Zhong Q, Feng G, Chen Q, Gou X, Zhang G. | 05/1/2021 |
| Dominant-Negative ATF5 Compromises Cancer Cell Survival by Targeting CEBPB and CEBPD. | Dominant-Negative ATF5 Compromises Cancer Cell Survival by Targeting CEBPB and CEBPD.
Sun X, Jefferson P, Zhou Q, Angelastro JM, Greene LA., Free PMC Article | 12/5/2020 |
| Expression of activating transcription factor 5 (ATF5) is mediated by microRNA-520b-3p under diverse cellular stress in cancer cells. | Expression of activating transcription factor 5 (ATF5) is mediated by microRNA-520b-3p under diverse cellular stress in cancer cells.
Gaither KA, Watson CJW, Madarampalli B, Lazarus P., Free PMC Article | 08/29/2020 |
| Data suggest that ATF5 is modified by SUMO2/3 at a conserved SUMO-targeting consensus site; this SUMOylation of ATF5 appears to be required for transport of ATF5 to centrosome. (ATF5 = activating transcription factor-5; SUMO = small ubiquitin-like modifier) | SUMO2/3 modification of activating transcription factor 5 (ATF5) controls its dynamic translocation at the centrosome.
Yuan Y, Gaither K, Kim E, Liu E, Hu M, Lengel K, Qian D, Xu Y, Wang B, Knipprath H, Liu DX., Free PMC Article | 12/22/2018 |
| Study reports that reduced levels of ATF5 in brain of Huntington's disease patients, probably due to its sequestration into the characteristic PolyQ containing neuronal inclusion bodies, correlates with decreased levels of the antiapoptotic protein MCL1, a transcriptional target of ATF5. Also provides evidence of decreased ATF5 being deleterious by rendering neurons more vulnerable to polyQ-induced apoptosis. | The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease.
Hernández IH, Torres-Peraza J, Santos-Galindo M, Ramos-Morón E, Fernández-Fernández MR, Pérez-Álvarez MJ, Miranda-Vizuete A, Lucas JJ. | 06/16/2018 |
| ATF5 expression can rescue UPR(mt) signaling in atfs-1-deficient worms requiring the same UPR(mt) promoter element identified in C. elegans. Furthermore, mammalian cells require ATF5 to maintain mitochondrial activity during mitochondrial stress and promote organelle recovery. Combined, these data suggest that regulation of the UPR(mt) is conserved from worms to mammals. | The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR.
Fiorese CJ, Schulz AM, Lin YF, Rosin N, Pellegrino MW, Haynes CM., Free PMC Article | 12/30/2017 |
| Our results suggest that ATF5 promotes invasion by inducing the expression of integrin-alpha2 and integrin-beta1 in several human cancer cell lines. | Role of ATF5 in the invasive potential of diverse human cancer cell lines.
Nukuda A, Endoh H, Yasuda M, Mizutani T, Kawabata K, Haga H. | 05/13/2017 |
| This study provides the first evidence that the methylation level of ATF5 decreased, and its mRNA expression was evidently up-regulated in glioma. | DNA methylation level of promoter region of activating transcription factor 5 in glioma.
Hua XM, Wang J, Qian DM, Song JY, Chen H, Zhu XL, Zhou R, Zhao YD, Zhou XZ, Li L, Zhang L, Song XX, Wang B., Free PMC Article | 06/28/2016 |
| These results suggest that the hepatic functions of the human iPS-HLCs could be enhanced by ATF5, c/EBPalpha, and PROX1 transduction. | Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction.
Nakamori D, Takayama K, Nagamoto Y, Mitani S, Sakurai F, Tachibana M, Mizuguchi H. | 05/28/2016 |
| Activating transcription factor 5 enhances radioresistance and malignancy in cancer. | Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells.
Ishihara S, Yasuda M, Ishizu A, Ishikawa M, Shirato H, Haga H., Free PMC Article | 01/16/2016 |
| Data show that ATF5 is an essential structural protein that is required for the interaction between the mother centriole and the pericentriolar material. | ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole.
Madarampalli B, Yuan Y, Liu D, Lengel K, Xu Y, Li G, Yang J, Liu X, Lu Z, Liu DX. | 10/31/2015 |
| Low expression level of ATF5 in hepatocellular carcinoma indicated aggressive tumor behavior and predicted a worse clinical outcome. | High ATF5 expression is a favorable prognostic indicator in patients with hepatocellular carcinoma after hepatectomy.
Wu Y, Wu B, Chen R, Zheng Y, Huang Z. | 10/24/2015 |
| Report a global loss of 5hmC identified three new genes (ECM1, ATF5, and EOMES) with potential anti-cancer functions that may promote the understanding of the molecular mechanisms of hepatocellular carcinoma development and progression. | Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma.
Gao F, Xia Y, Wang J, Lin Z, Ou Y, Liu X, Liu W, Zhou B, Luo H, Zhou B, Wen B, Zhang X, Huang J., Free PMC Article | 08/22/2015 |
| the TAK1-NLK pathway is a novel regulator of basal or IL-1beta-triggered C/EBP activation though stabilization of ATF5 | Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway.
Zhang ZY, Li SZ, Zhang HH, Wu QR, Gong J, Liang T, Gao L, Xing NN, Liu WB, Du RL, Zhang XD., Free PMC Article | 04/18/2015 |
| ATF5 promotes the proliferation of HSV-1 via a potential mechanism by which ATF5 enhances the transcription of viral genes during the course of an HSV-1 infection | A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5.
Wu L, Zhang X, Che Y, Zhang Y, Tang S, Liao Y, Na R, Xiong X, Liu L, Li Q. | 08/23/2014 |
| N-terminal hydrophobic amino acids play an important role in the regulation of ATF5 protein expression in IL-1beta-mediated immune response and that ATF5 is a negative regulator for IL-1beta-induced expression of SAA1 and SAA2 in HepG2 cells. | N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization.
Abe T, Kojima M, Akanuma S, Iwashita H, Yamazaki T, Okuyama R, Ichikawa K, Umemura M, Nakano H, Takahashi S, Takahashi Y., Free PMC Article | 05/3/2014 |