| PHLDA1 is a P53 target gene involved in P53-mediated cell apoptosis. | PHLDA1 is a P53 target gene involved in P53-mediated cell apoptosis.
Song X, Zhou L, Yang W, Li X, Ma J, Qi K, Liang R, Li M, Xie L, Su T, Huang D, Liang B. | 03/27/2024 |
| Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice. | Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice.
Yousof TR, Bouchard CC, Alb M, Lynn EG, Lhoták S, Jiang H, MacDonald M, Li H, Byun JH, Makda Y, Athanasopoulos M, Maclean KN, Cherrington NJ, Naqvi A, Igdoura SA, Krepinsky JC, Steinberg GR, Austin RC., Free PMC Article | 03/6/2024 |
| PHLDA1 promotes glioblastoma cell growth via sustaining the activation state of Ras. | PHLDA1 promotes glioblastoma cell growth via sustaining the activation state of Ras.
Wang J, Yao N, Hu Y, Lei M, Wang M, Yang L, Patel S, Li X, Liu K, Dong Z. | 10/1/2022 |
| Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer. | Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer.
R Mangone F, Av Valoyes M, G do Nascimento R, Pf Conceição M, R Bastos D, C Pavanelli A, C Soares I, S de Mello E, Nonogaki S, Ab de T Osório C, A Nagai M. | 10/16/2021 |
| BMP4 and PHLDA1 are plausible drug-targetable candidate genes for KRAS G12A-, G12D-, and G12V-driven colorectal cancer. | BMP4 and PHLDA1 are plausible drug-targetable candidate genes for KRAS G12A-, G12D-, and G12V-driven colorectal cancer.
Ohnami S, Maruyama K, Chen K, Takahashi Y, Hatakeyama K, Ohshima K, Shimoda Y, Sakai A, Kamada F, Nakatani S, Naruoka A, Ohnami S, Kusuhara M, Akiyama Y, Kagawa H, Shiomi A, Nagashima T, Urakami K, Yamaguchi K., Free PMC Article | 09/11/2021 |
| TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells. | TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells.
Platko K, Lebeau PF, Gyulay G, Lhoták Š, MacDonald ME, Pacher G, Hyun Byun J, Boivin FJ, Igdoura SA, Cutz JC, Bridgewater D, Ingram AJ, Krepinsky JC, Austin RC. | 10/10/2020 |
| there was no virtual stimulation of autophagy in the 14G2a mAb-treated CHP-134 neuroblastoma cells, we were able to show that PHLDA1 protein positively regulates autophagy and this process exists in a mutually exclusive manner with apoptosis in PHLDA1-silenced CHP-134 cells. | GD2 ganglioside-binding antibody 14G2a and specific aurora A kinase inhibitor MK-5108 induce autophagy in IMR-32 neuroblastoma cells.
Durbas M, Pabisz P, Wawak K, Wiśniewska A, Boratyn E, Nowak I, Horwacik I, Woźnicka O, Rokita H., Free PMC Article | 09/28/2019 |
| PHLDA1 is a biomarker for drug response. | PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer.
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y, Wang J, Gadaleta E, Chelala C, Moore KM, Marshall JF, Chupin J, Schmid P, Jones JL, Lockley M, Cutillas PR, Grose RP., Free PMC Article | 06/22/2019 |
| that PHLDA1 downregulation in MCF10A cells leads to morphological changes and a more aggressive behavior | PHLDA1 (pleckstrin homology-like domain, family A, member 1) knockdown promotes migration and invasion of MCF10A breast epithelial cells.
Bonatto N, Carlini MJ, de Bessa Garcia SA, Nagai MA., Free PMC Article | 05/18/2019 |
| suggest a unique regulatory feature of PHLDA1 to inhibit the ErbB receptor oligomerization process and thereby control the activity of receptor signaling network. | Transcriptionally inducible Pleckstrin homology-like domain, family A, member 1, attenuates ErbB receptor activity by inhibiting receptor oligomerization.
Magi S, Iwamoto K, Yumoto N, Hiroshima M, Nagashima T, Ohki R, Garcia-Munoz A, Volinsky N, Von Kriegsheim A, Sako Y, Takahashi K, Kimura S, Kholodenko BN, Okada-Hatakeyama M., Free PMC Article | 12/22/2018 |
| Data identified PHLDA1 as a novel p53 target with an ability to repress Akt. PHLDA1 has a so-called split PH domain divided into an N-terminal and a C-terminal portions and seems to be responsible for its localization to the plasma membrane and binding to phosphatidylinositol. In addition, PHLDA1 expression analysis suggests that PHLDA1 has a tumor suppressive function in breast and ovarian cancers. | PHLDA1, another PHLDA family protein that inhibits Akt.
Chen Y, Takikawa M, Tsutsumi S, Yamaguchi Y, Okabe A, Shimada M, Kawase T, Sada A, Ezawa I, Takano Y, Nagata K, Suzuki Y, Semba K, Aburatani H, Ohki R., Free PMC Article | 11/24/2018 |
| Our study negatively correlates expression of PHLDA1 and Aurora A in IMR-32 cells and sheds new light on functions of PHLDA1 in the neuroblastoma tumor cells, suggesting its role as a pro-apoptotic protein | Downregulation of the PHLDA1 gene in IMR-32 neuroblastoma cells increases levels of Aurora A, TRKB and affects proteins involved in apoptosis and autophagy pathways.
Durbas M, Horwacik I, Boratyn E, Rokita H. | 04/8/2017 |
| Suggest decreased expression of PHLDA1 may play an important role in tumor progression, and may become a new adjunct biomarker in the prognosis in gastric adenocarcinoma. | Correlation of decreased expression of PHLDA1 protein with malignant phenotype of gastric adenocarcinoma.
Zhao P, Lu Y, Liu L., Free PMC Article | 04/23/2016 |
| Data suggest that high PHLDA1 expression is controlled through an ER-NFkappaB-miR-181 regulatory axis and may contribute to a poor clinical outcome in patients with ER+ breast tumors by enhancing stem-like properties in these tumors. | PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
Kastrati I, Canestrari E, Frasor J., Free PMC Article | 07/25/2015 |
| PHLDA1 expression is a useful addition in differentiating trichoblastoma and basal cell carcinoma. | PHLDA1, a follicular stem cell marker, differentiates clear-cell/granular-cell trichoblastoma and clear-cell/granular cell basal cell carcinoma: a case-control study, with first description of granular-cell trichoblastoma.
Battistella M, Peltre B, Cribier B. | 04/11/2015 |
| A role for PHLDA1 as an apoptosis suppressor in oral cancer cells. | Differential susceptibility to hydrogen sulfide-induced apoptosis between PHLDA1-overexpressing oral cancer cell lines and oral keratinocytes: role of PHLDA1 as an apoptosis suppressor.
Murata T, Sato T, Kamoda T, Moriyama H, Kumazawa Y, Hanada N. | 03/15/2014 |
| Data show that downregulation of aurora A kinase by the therapeutic antibody is associated with decreased levels of MYCN protein in cytoplasm, and induced expression of PHLDA1 and P53 proteins. | Targeting GD2 ganglioside and aurora A kinase as a dual strategy leading to cell death in cultures of human neuroblastoma cells.
Horwacik I, Durbas M, Boratyn E, Węgrzyn P, Rokita H. | 01/18/2014 |
| The follicular stem cell marker PHLDA1 (TDAG51) indicates that most basaloid tumors in nevus sebaceus are basal cell carcinomas and not trichoblastomas. | Basaloid tumors in nevus sebaceus revisited: the follicular stem cell marker PHLDA1 (TDAG51) indicates that most are basal cell carcinomas and not trichoblastomas.
Sellheyer K, Cribier B, Nelson P, Kutzner H, Rütten A. | 10/19/2013 |
| PHLDA1 differentiates between desmoplastic trichoepithelioma and morpheaform basal cell carcinoma but shows variable staining in microcystic adnexal carcinoma. | The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers.
Sellheyer K, Nelson P, Kutzner H, Patel RM. | 09/7/2013 |
| the release of Ca(2+) from endoplasmic reticulum stores mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium via the induction of TDAG51 | TDAG51 mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium.
Carlisle RE, Heffernan A, Brimble E, Liu L, Jerome D, Collins CA, Mohammed-Ali Z, Margetts PJ, Austin RC, Dickhout JG. | 10/13/2012 |
| crucial negative regulator and effector of Aurora A kinase in breast cancer | PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.
Johnson EO, Chang KH, de Pablo Y, Ghosh S, Mehta R, Badve S, Shah K. | 12/10/2011 |
| PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis | PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.
Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. | 07/23/2011 |
| The anti-estrogen ICI 182,780 (1 microM) inhibited PHLDA1 mRNA expression and completely abolished the effect of 10 nM 17beta-estradiol on PHLDA1 expression (P < 0.05), suggesting that PHLDA1 is regulated by estrogen via ER. | Transcriptional up-regulation of PHLDA1 by 17beta-estradiol in MCF-7 breast cancer cells.
Marchiori AC, Casolari DA, Nagai MA. | 01/21/2010 |
| Reduced PHLDA1 expression is important in breast cancer progression and could serve as useful prognostic marker of disease outcome. | Down-regulation of PHLDA1 gene expression is associated with breast cancer progression.
Nagai MA, Fregnani JH, Netto MM, Brentani MM, Soares FA. | 01/21/2010 |
| TDAG51 in patients with intractable epilepsy was significantly higher when compared with levels in the controls. | TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy.
Xi ZQ, Wang LY, Sun JJ, Liu XZ, Zhu X, Xiao F, Guan LF, Li JM, Wang L, Wang XF. | 01/21/2010 |