| Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1. | Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1.
He Y, Zhang X, Pan W, Zhang J, Zhu W, Zhang J, Shi J., Free PMC Article | 06/13/2024 |
| The Scaffold Protein KATNIP Enhances CILK1 Control of Primary Cilia. | The Scaffold Protein KATNIP Enhances CILK1 Control of Primary Cilia.
Turner JS, McCabe EA, Kuang KW, Gailey CD, Brautigan DL, Limerick A, Wang EX, Fu Z., Free PMC Article | 09/21/2023 |
| BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1. | BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1.
Satoda Y, Noguchi T, Fujii T, Taniguchi A, Katoh Y, Nakayama K., Free PMC Article | 07/30/2022 |
| Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy. | Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy.
Wang EJ, Gailey CD, Brautigan DL, Fu Z., Free PMC Article | 03/13/2021 |
| Anterograde trafficking of ciliary MAP kinase-like ICK/CILK1 by the intraflagellar transport machinery is required for intraciliary retrograde protein trafficking. | Anterograde trafficking of ciliary MAP kinase-like ICK/CILK1 by the intraflagellar transport machinery is required for intraciliary retrograde protein trafficking.
Nakamura K, Noguchi T, Takahara M, Omori Y, Furukawa T, Katoh Y, Nakayama K., Free PMC Article | 02/2/2021 |
| Previously known as intestinal cell kinase because it was cloned from that origin, CILK1 is now recognized as a widely expressed and highly conserved. Mutations in the human CILK1 gene have been associated with ciliopathies. Thus, CILK1 has a fundamental role in the function of the cilium. Several candidate substrates have been proposed for CILK1. [review] | Ciliogenesis associated kinase 1: targets and functions in various organ systems.
Fu Z, Gailey CD, Wang EJ, Brautigan DL., Free PMC Article | 06/20/2020 |
| Study demonstrates that human ICK (intestinal cell kinase) that authors herein call CAPK (ciliopathy-associated protein kinase) interacts with human KIF3A and phosphorylates a conserved site Thr672 both in vitro and in vivo. Long, unstructured, non-catalytic carboxyl-terminal domain (CTD) of CAPK is required for this interaction with and phosphorylation of KIF3A. | Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis.
Oh YS, Wang EJ, Gailey CD, Brautigan DL, Allen BL, Fu Z., Free PMC Article | 01/4/2020 |
| Our data provide evidence that heterozygous variants in ICK caused juvenile myoclonic epilepsy in 7% of the patients included in our analysis. Variant ICK affects cell processes that help explain microdysgenesis and polyspike networks observed on EEG in juvenile myoclonic epilepsy. | Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy.
Bailey JN, de Nijs L, Bai D, Suzuki T, Miyamoto H, Tanaka M, Patterson C, Lin YC, Medina MT, Alonso ME, Serratosa JM, Durón RM, Nguyen VH, Wight JE, Martínez-Juárez IE, Ochoa A, Jara-Prado A, Guilhoto L, Molina Y, Yacubian EM, López-Ruiz M, Inoue Y, Kaneko S, Hirose S, Osawa M, Oguni H, Fujimoto S, Grisar TM, Stern JM, Yamakawa K, Lakaye B, Delgado-Escueta AV. | 03/24/2018 |
| These data identify ICK as an short rib polydactyly syndromes (SRPS)-associated gene and reveal that abnormalities in signalling pathways contribute to defective skeletogenesis | An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.
Paige Taylor S, Kunova Bosakova M, Varecha M, Balek L, Barta T, Trantirek L, Jelinkova I, Duran I, Vesela I, Forlenza KN, Martin JH, Hampl A, University of Washington Center for Mendelian Genomics, Bamshad M, Nickerson D, Jaworski ML, Song J, Ko HW, Cohn DH, Krakow D, Krejci P., Free PMC Article | 07/22/2017 |
| findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress. | Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition.
Bolick DT, Chen T, Alves LA, Tong Y, Wu D, Joyner LT 2nd, Oriá RB, Guerrant RL, Fu Z., Free PMC Article | 12/5/2015 |
| the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. | Distinct expression patterns of ICK/MAK/MOK protein kinases in the intestine implicate functional diversity.
Chen T, Wu D, Moskaluk CA, Fu Z., Free PMC Article | 11/29/2014 |
| In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation. | CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner.
Yang Y, Roine N, Mäkelä TP., Free PMC Article | 10/26/2013 |
| High ICK expression is associated with prostate cancer. | Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen.
Whitworth H, Bhadel S, Ivey M, Conaway M, Spencer A, Hernan R, Holemon H, Gioeli D., Free PMC Article | 03/30/2013 |
| an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor Thr-908. | Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.
Wu D, Chapman JR, Wang L, Harris TE, Shabanowitz J, Hunt DF, Fu Z., Free PMC Article | 06/9/2012 |
| Findings demonstrate an important role for ICK in proliferation and differentiation of intestinal epithelial cells. | Intestinal cell kinase, a MAP kinase-related kinase, regulates proliferation and G1 cell cycle progression of intestinal epithelial cells.
Fu Z, Kim J, Vidrich A, Sturgill TW, Cohn SM, Fu Z, Kim J, Vidrich A, Sturgill TW, Cohn SM., Free PMC Articles: PMC2763805, PMC2763805 | 10/30/2010 |
| ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. | The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors.
Sturgill TW, Stoddard PB, Cohn SM, Mayo MW., Free PMC Article | 08/2/2010 |
| PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe, an essential regulator of proliferation and apoptosis during mammalian development. | Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase.
Fu Z, Larson KA, Chitta RK, Parker SA, Turk BE, Lawrence MW, Kaldis P, Galaktionov K, Cohn SM, Shabanowitz J, Hunt DF, Sturgill TW., Free PMC Article | 03/5/2010 |
| ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1, c-Myc and p21Cip1. | Intestinal cell kinase, a MAP kinase-related kinase, regulates proliferation and G1 cell cycle progression of intestinal epithelial cells.
Fu Z, Kim J, Vidrich A, Sturgill TW, Cohn SM, Fu Z, Kim J, Vidrich A, Sturgill TW, Cohn SM., Free PMC Articles: PMC2763805, PMC2763805 | 03/5/2010 |
| ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity | A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems.
Lahiry P, Wang J, Robinson JF, Turowec JP, Litchfield DW, Lanktree MB, Gloor GB, Puffenberger EG, Strauss KA, Martens MB, Ramsay DA, Rupar CA, Siu V, Hegele RA., Free PMC Article | 02/1/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C. | 04/1/2009 |
| ICK is the prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs. | Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase.
Fu Z, Schroeder MJ, Shabanowitz J, Kaldis P, Togawa K, Rustgi AK, Hunt DF, Sturgill TW., Free PMC Article | 01/21/2010 |