| SNW1 interacts with IKKgamma to positively regulate antiviral innate immune responses against influenza A virus infection. | SNW1 interacts with IKKγ to positively regulate antiviral innate immune responses against influenza A virus infection.
Zhang Q, Liang T, Gu S, Ye Y, Liu S. | 07/3/2021 |
| Skip is essential for Notch signaling to induce Sox2 in cerebral arteriovenous malformations. | Skip is essential for Notch signaling to induce Sox2 in cerebral arteriovenous malformations.
Zhang D, Qiao X, Wang L, Zhang L, Yao J, Wu X, Yu T, Boström KI, Yao Y., Free PMC Article | 06/12/2021 |
| SNW1 is a unique protein previously shown to be involved in both splicing and transcription, and in this case, its role involves binding to the NF-kappaB-p-TEFb complex to facilitate transcriptional elongation of some NF-kappaB target genes. | SNW1, a Novel Transcriptional Regulator of the NF-κB Pathway.
Verma S, De Jesus P, Chanda SK, Verma IM., Free PMC Article | 12/7/2019 |
| These results demonstrate that SNW1 overexpression is an independent prognostic marker in prostate cancer with potential clinical utility. | SNW1 is a prognostic biomarker in prostate cancer.
Höflmayer D, Willich C, Hube-Magg C, Simon R, Lang D, Neubauer E, Jacobsen F, Hinsch A, Luebke AM, Tsourlakis MC, Huland H, Graefen M, Haese A, Heinzer H, Minner S, Büscheck F, Sauter G, Schlomm T, Steurer S, Clauditz TS, Burandt E, Wilczak W, Bernreuther C., Free PMC Article | 11/30/2019 |
| SNW1 interacts with RBPJ to regulate the Notch signaling pathway in neuroblastoma | SNW1 regulates Notch signaling in neuroblastoma through interacting with RBPJ.
Hong M, He J, Li S. | 11/9/2019 |
| c-Abl promotes TGF-beta-induced SKIP/Smad3 interaction. | Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).
Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N. | 08/12/2017 |
| Higher SKIP expression is associated with poor prognosis in malignant pleural mesothelioma | Comparison of SKIP expression in malignant pleural mesotheliomas with Ki-67 proliferation index and prognostic parameters.
Türkcü G, AlabalIk U, Keles AN, Ibiloglu I, Küçüköner M, Sen HS, Büyükbayram H. | 01/28/2017 |
| Upon step 1 catalysis, Cwc25 contacts with the branch-site region, and enhanced crosslinks of Prp8 and Prp45 with nucleotides surrounding the branch-site were observed. | Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes.
Schneider C, Agafonov DE, Schmitzová J, Hartmuth K, Fabrizio P, Lührmann R., Free PMC Article | 04/30/2016 |
| Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP | Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP.
Ishida M, Ohbayashi N, Fukuda M., Free PMC Article | 11/28/2015 |
| Results show that SNW1 directly associates with EFTUD2 and SNRNP200 and that disruption of SNW1 association with these proteins promotes the apoptosis of breast cancer cells. | Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells.
Sato N, Maeda M, Sugiyama M, Ito S, Hyodo T, Masuda A, Tsunoda N, Kokuryo T, Hamaguchi M, Nagino M, Senga T., Free PMC Article | 09/26/2015 |
| A transcriptome-wide analysis revealed that SNW1 or PRPF8 depletion affects the splicing of specific introns in a subset of pre-mRNAs, including pre-mRNAs encoding the cohesion protein sororin and the APC/C subunit APC2. | SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
van der Lelij P, Stocsits RR, Ladurner R, Petzold G, Kreidl E, Koch B, Schmitz J, Neumann B, Ellenberg J, Peters JM., Free PMC Article | 02/14/2015 |
| SKIP overexpression is involved in the pathogenesis of breast cancer. | Expression and prognostic role of SKIP in human breast carcinoma.
Liu X, Ni Q, Xu J, Sheng C, Wang Q, Chen J, Yang S, Wang H. | 10/25/2014 |
| High SKIP expression was detected in clinical HCC samples. | High SKIP expression is correlated with poor prognosis and cell proliferation of hepatocellular carcinoma.
Liu G, Huang X, Cui X, Zhang J, Wei L, Ni R, Lu C. | 04/19/2014 |
| SKIP increased 5alpha-dihydrotestosterone (DHT) induced N-terminal/C-terminal AR interaction from 12-fold to almost 300-fold in a two-hybrid assay, and enhanced AR ligand-independent AF-1 transactivation. | Ski-interacting protein (SKIP) interacts with androgen receptor in the nucleus and modulates androgen-dependent transcription.
Abankwa D, Millard SM, Martel N, Choong CS, Yang M, Butler LM, Buchanan G, Tilley WD, Ueki N, Hayman MJ, Leong GM., Free PMC Article | 09/28/2013 |
| Arl8 and SKIP are required for lysosomes to distribute away from the microtubule-organizing center. We identify two kinesin light chain binding motifs in SKIP that are required for lysosomes to accumulate kinesin-1 and redistribute to the cell periphery. | Arl8 and SKIP act together to link lysosomes to kinesin-1.
Rosa-Ferreira C, Munro S., Free PMC Article | 02/18/2012 |
| SKIP is required for epithelial mesenchymal transition and invasiveness induced by TGF-beta1 in transformed cells. | SKIP is required for TGF-β1-induced epithelial mesenchymal transition and migration in transformed keratinocytes.
Villar V, Kocic J, Bugarski D, Jovcic G, Santibanez JF. | 02/3/2012 |
| This suggests that transcription of stress response genes, unlike, e.g., the SNW1-sensitive mitosis-specific genes, can proceed uncoupled from regulators that normally function under physiological conditions. | Stress-induced expression of p53 target genes is insensitive to SNW1/SKIP downregulation.
Tolde O, Folk P., Free PMC Article | 12/10/2011 |
| molecular model for the binding mode of SKIP to PPIL1 which emphasizes the versatility of cyclophilin-type PPIases to engage in additional interactions with other proteins apart from active site contacts despite their limited surface area. | The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein.
Stegmann CM, Lührmann R, Wahl MC., Free PMC Article | 06/18/2011 |
| SKIP is essential for p53 stress-induced expression of the p21 | SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing.
Chen Y, Zhang L, Jones KA., Free PMC Article | 05/21/2011 |
| The large disordered region in SKIP provides an interaction platform. Its disorder-order transition, induced by PPIL1 binding, may adapt the requirement for a large structural rearrangement occurred in the activation of spliceosome | A large intrinsically disordered region in SKIP and its disorder-order transition induced by PPIL1 binding revealed by NMR.
Wang X, Zhang S, Zhang J, Huang X, Xu C, Wang W, Liu Z, Wu J, Shi Y., Free PMC Article | 05/31/2010 |
| SIRT1 associates with SKI-interacting protein (SKIP) and modulates its activity as a coactivator of retinoic acid receptor. | Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells.
Kang MR, Lee SW, Um E, Kang HT, Hwang ES, Kim EJ, Um SJ., Free PMC Article | 04/12/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.
Couch FJ, Wang X, Bamlet WR, de Andrade M, Petersen GM, McWilliams RR., Free PMC Article | 04/7/2010 |
| SKIP acts with c-Myc and Menin to promote HIV-1 Tat:P-TEFb transcription at an elongation step that is bypassed under stress. | SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation.
Brès V, Yoshida T, Pickle L, Jones KA., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Asthma and genes encoding components of the vitamin D pathway.
Bossé Y, Lemire M, Poon AH, Daley D, He JQ, Sandford A, White JH, James AL, Musk AW, Palmer LJ, Raby BA, Weiss ST, Kozyrskyj AL, Becker A, Hudson TJ, Laprise C., Free PMC Article | 12/2/2009 |
| SifA, SKIP, SseJ, and RhoA family GTPases cooperatively promote host membrane tubulation. | Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation.
Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI., Free PMC Article | 01/21/2010 |