| Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies. | Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies.
Scalia F, Lo Bosco G, Paladino L, Vitale AM, Noori L, Conway de Macario E, Macario AJL, Bucchieri F, Cappello F, Lo Celso F., Free PMC Article | 03/1/2023 |
| CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/beta-catenin signalling pathway. | CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway.
Li Y, Liu C, Zhang X, Huang X, Liang S, Xing F, Tian H., Free PMC Article | 06/18/2022 |
| CCT5 interacts with cyclin D1 promoting lung adenocarcinoma cell migration and invasion. | CCT5 interacts with cyclin D1 promoting lung adenocarcinoma cell migration and invasion.
Meng Y, Yang L, Wei X, Luo H, Hu Y, Tao X, He J, Zheng X, Xu Q, Luo K, Yu G, Luo Q. | 11/22/2021 |
| A Novel CCT5 Missense Variant Associated with Early Onset Motor Neuropathy. | A Novel CCT5 Missense Variant Associated with Early Onset Motor Neuropathy.
Antona V, Scalia F, Giorgio E, Radio FC, Brusco A, Oliveri M, Corsello G, Lo Celso F, Vadalà M, Conway de Macario E, Macario AJL, Cappello F, Giuffrè M., Free PMC Article | 02/27/2021 |
| CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex | Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.
Darrow MC, Sergeeva OA, Isas JM, Galaz-Montoya JG, King JA, Langen R, Schmid MF, Chiu W., Free PMC Article | 10/3/2015 |
| H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5. | Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy.
Sergeeva OA, Tran MT, Haase-Pettingell C, King JA., Free PMC Article | 12/20/2014 |
| Both CCT4 and CCT5 homo-oligomers have the property of forming 8-fold double rings absent the other subunits, and these complexes carry out chaperonin reactions without other partner subunits. | Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.
Sergeeva OA, Chen B, Haase-Pettingell C, Ludtke SJ, Chiu W, King JA., Free PMC Article | 08/31/2013 |
| introduction of the truncated human CCT epsilon subunit into yeast cells | A novel function of the human chaperonin CCT epsilon subunit in yeast.
Nikawa J, Kimura M. | 05/19/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation study of 182 candidate genes in anorexia nervosa.
Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB. Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation.
Rotthier A, Baets J, De Vriendt E, Jacobs A, Auer-Grumbach M, Lévy N, Bonello-Palot N, Kilic SS, Weis J, Nascimento A, Swinkels M, Kruyt MC, Jordanova A, De Jonghe P, Timmerman V. A genome-wide scan maps a novel high myopia locus to 5p15.
Lam CY, Tam PO, Fan DS, Fan BJ, Wang DY, Lee CW, Pang CP, Lam DS. | 05/11/2008 |
| mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel. | Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers.
Ooe A, Kato K, Noguchi S. | 01/21/2010 |
| A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia. | Mutation in the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia.
Bouhouche A, Benomar A, Bouslam N, Chkili T, Yahyaoui M., Free PMC Article | 01/21/2010 |