| RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32. | RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32.
Wang L, Song YY, Wang Y, Liu XX, Yin YL, Gao S, Zhang F, Li LY, Zhang ZS. | 12/6/2023 |
| TRIM32 promotes oral squamous cell carcinoma progression by enhancing FBP2 ubiquitination and degradation. | TRIM32 promotes oral squamous cell carcinoma progression by enhancing FBP2 ubiquitination and degradation.
Yang X, Ma H, Zhang M, Wang R, Li X. | 09/19/2023 |
| Tripartite Motif-Containing Protein 32 (TRIM32): What Does It Do for Skeletal Muscle? | Tripartite Motif-Containing Protein 32 (TRIM32): What Does It Do for Skeletal Muscle?
Jeong SY, Choi JH, Kim J, Woo JS, Lee EH., Free PMC Article | 08/28/2023 |
| Overexpression of TRIM32 promotes pancreatic beta-cell autophagic cell death through Akt/mTOR pathway under high glucose conditions. | Overexpression of TRIM32 promotes pancreatic β-cell autophagic cell death through Akt/mTOR pathway under high glucose conditions.
Wan T, Wang Y, Wang C, Wang H, Li X, Li Y. | 11/29/2022 |
| TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3beta/Nrf2 Pathway. | TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Chen Z, Tian L, Wang L, Ma X, Lei F, Chen X, Fu R. | 05/21/2022 |
| TRIM32 promotes radioresistance by disrupting TC45-STAT3 interaction in triple-negative breast cancer. | TRIM32 promotes radioresistance by disrupting TC45-STAT3 interaction in triple-negative breast cancer.
Ma Y, Zhang H, Chen C, Liu L, Ding T, Wang Y, Ma D, Ling X, Chen X, Li J, Guansheng, Zhong, Ru G, Zhang L, Tang J. | 04/30/2022 |
| TRIM32 inhibits the proliferation and migration of pulmonary artery smooth muscle cells through the inactivation of PI3K/Akt pathway in pulmonary arterial hypertension. | TRIM32 inhibits the proliferation and migration of pulmonary artery smooth muscle cells through the inactivation of PI3K/Akt pathway in pulmonary arterial hypertension.
Hu Z, Song Q, Ma H, Guo Y, Zhang T, Xie H, Luo X. | 02/5/2022 |
| TRIM32 regulates mitochondrial mediated ROS levels and sensitizes the oxidative stress induced cell death. | TRIM32 regulates mitochondrial mediated ROS levels and sensitizes the oxidative stress induced cell death.
Prajapati P, Gohel D, Shinde A, Roy M, Singh K, Singh R. | 12/4/2021 |
| Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling. | Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling.
Zhu JW, Zou MM, Li YF, Chen WJ, Liu JC, Chen H, Fang LP, Zhang Y, Wang ZT, Chen JB, Huang W, Li S, Jia WQ, Wang QQ, Zhen XC, Liu CF, Li S, Xiao ZC, Xu GQ, Schwamborn JC, Schachner M, Ma QH, Xu RX. | 11/22/2021 |
| Generation of the short TRIM32 isoform is regulated by Lys 247 acetylation and a PEST sequence. | Generation of the short TRIM32 isoform is regulated by Lys 247 acetylation and a PEST sequence.
Garcia-Garcia J, Overå KS, Khan W, Sjøttem E., Free PMC Article | 10/16/2021 |
| Deletion of HNF1A-AS1 Suppresses the Malignant Phenotypes of Breast Cancer Cells In Vitro and In Vivo Through Targeting miRNA-20a-5p/TRIM32 Axis. | Deletion of HNF1A-AS1 Suppresses the Malignant Phenotypes of Breast Cancer Cells In Vitro and In Vivo Through Targeting miRNA-20a-5p/TRIM32 Axis.
Meng Q, Wang L, Lv Y, Wu J, Shi W. | 10/9/2021 |
| Costameric integrin and sarcoglycan protein levels are altered in a Drosophila model for Limb-girdle muscular dystrophy type 2H. | Costameric integrin and sarcoglycan protein levels are altered in a Drosophila model for Limb-girdle muscular dystrophy type 2H.
Bawa S, Gameros S, Baumann K, Brooks DS, Kollhoff JA, Zolkiewski M, Re Cecconi AD, Panini N, Russo M, Piccirillo R, Johnson DK, Kashipathy MM, Battaile KP, Lovell S, Bouyain SEA, Kawakami J, Geisbrecht ER., Free PMC Article | 08/21/2021 |
| Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner. | Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner.
Cai Y, Gu WT, Cheng K, Jia PF, Li F, Wang M, Zhang WF, Qiu JT, Wu ZB, Zhao WG. | 06/26/2021 |
| TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma. | TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma.
Luo Q, Wu X, Nan Y, Chang W, Zhao P, Zhang Y, Su D, Liu Z. | 01/9/2021 |
| TRIM32 Promotes the Growth of Gastric Cancer Cells through Enhancing AKT Activity and Glucose Transportation. | TRIM32 Promotes the Growth of Gastric Cancer Cells through Enhancing AKT Activity and Glucose Transportation.
Wang J, Fang Y, Liu T., Free PMC Article | 11/21/2020 |
| A TRIM32(LGMD2H) disease mutant was unable to undergo autophagic degradation and to mono-ubiquitylate p62, and its reintroduction into the TRIM32-knockout cells did not affect p62 dot formation. | TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1.
Overå KS, Garcia-Garcia J, Bhujabal Z, Jain A, Øvervatn A, Larsen KB, Deretic V, Johansen T, Lamark T, Sjøttem E., Free PMC Article | 07/25/2020 |
| TRIM32 may regulate lung cancer cell proliferation, apoptosis, and motility. | Expression and the potential functions of TRIM32 in lung cancer tumorigenesis.
Yin H, Li Z, Chen J, Hu X. | 07/11/2020 |
| this study shows that TRIM32 promotes inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes | TRIM32 promotes inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes.
Liang T, Song M, Xu K, Guo C, Xu H, Zhang H, Xu L. | 06/13/2020 |
| A mutation in TRIM32 causes muscle dystrophy and reduced levels of TRIM32 was observed in all patient muscle studied. | Altered myogenesis and premature senescence underlie human TRIM32-related myopathy.
Servián-Morilla E, Cabrera-Serrano M, Rivas-Infante E, Carvajal A, Lamont PJ, Pelayo-Negro AL, Ravenscroft G, Junckerstorff R, Dyke JM, Fletcher S, Adams AM, Mavillard F, Fernández-García MA, Nieto-González JL, Laing NG, Paradas C., Free PMC Article | 04/4/2020 |
| In a cohort of non-Hutterite TRIM32 myopathy patients, several pathogenic variants are identified. | Extending the clinical and mutational spectrum of TRIM32-related myopathies in a non-Hutterite population.
Johnson K, De Ridder W, Töpf A, Bertoli M, Phillips L, De Jonghe P, Baets J, Deconinck T, Rakocevic Stojanovic V, Perić S, Durmus H, Jamal-Omidi S, Nafissi S, Mongini T, Łusakowska A, Busby M, Miller J, Norwood F, Hudson J, Barresi R, Lek M, MacArthur DG, Straub V., Free PMC Article | 12/14/2019 |
| the RING domain of TRIM32 protein is crucial for E3 ligase activity and E2 specificity, whereas a complete B-box domain is involved in chain assembly rate modulation. | Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.
Lazzari E, El-Halawany MS, De March M, Valentino F, Cantatore F, Migliore C, Onesti S, Meroni G., Free PMC Article | 12/7/2019 |
| we found that the mechanism behind the TRIM32-promoted GC progression was related to the b-catenin signalling pathway. Collectively, these data suggest that TRIM32 promotes GC cell proliferation, migration, and invasion by activating the b-catenin signalling pathway. | TRIM32 promotes cell proliferation and invasion by activating β-catenin signalling in gastric cancer.
Wang C, Xu J, Fu H, Zhang Y, Zhang X, Yang D, Zhu Z, Wei Z, Hu Z, Yan R, Cai Q., Free PMC Article | 11/23/2019 |
| TRIM32 as a crucial positive regulator of Herpes Simplex Virus type 1 (HSV-1) induced IFN-beta production in corneal epithelial cells, and it played a predominant role in clearing HSV-1 from the cornea. | Roles of TRIM32 in Corneal Epithelial Cells After Infection with Herpes Simplex Virus.
Cui H, Liu Y, Huang Y. | 11/4/2017 |
| HSP70-TRIM32 complex is biochemically distinct from the previously characterized 14-3-3-TRIM32 phospho-complex. | TRIM32-Cytoplasmic-Body Formation Is an ATP-Consuming Process Stimulated by HSP70 in Cells.
Kawaguchi Y, Taoka M, Takekiyo T, Uekita T, Shoji I, Hachiya N, Ichimura T., Free PMC Article | 08/12/2017 |
| Data suggest that, in cardiomyocytes, TRIM32 attenuates activation of SRF signaling and hypertrophy due to dysbindin; TRIM24 promotes these effects. TRIM32 promotes dysbindin degradation; TRIM24 protects dysbindin from degradation. (TRIM = tripartite motif-containing protein; SRF = serum response factor) | TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels.
Borlepawar A, Rangrez AY, Bernt A, Christen L, Sossalla S, Frank D, Frey N., Free PMC Article | 07/8/2017 |