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    FOXC1 forkhead box C1 [ Homo sapiens (human) ]

    Gene ID: 2296, updated on 1-Jul-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence.

    Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence.
    Li B, Xiong W, Zuo W, Shi Y, Wang T, Chang L, Wu Y, Ma H, Bian Q, Chang ACY., Free PMC Article

    06/25/2024
    Variants in FOXC1 and FOXC2 identified in patients with conotruncal heart defects.

    Variants in FOXC1 and FOXC2 identified in patients with conotruncal heart defects.
    Wei W, Li B, Li F, Sun K, Jiang X, Xu R.

    06/3/2024
    Reciprocal regulation of forkhead box C1 and L1 cell adhesion molecule contributes to triple-negative breast cancer progression.

    Reciprocal regulation of forkhead box C1 and L1 cell adhesion molecule contributes to triple-negative breast cancer progression.
    Zhang F, Xu Y, Lin J, Pan H, Giuliano AE, Cui X, Cui Y., Free PMC Article

    03/26/2024
    Research progress on the regulatory mechanisms of FOXC1 expression in cancers and its role in drug resistance.

    Research progress on the regulatory mechanisms of FOXC1 expression in cancers and its role in drug resistance.
    Yang Y, Li W, Yang H, Zhang Y, Zhang S, Xu F, Hao Y, Cao W, Du G, Wang J.

    02/5/2024
    FoxC1 activates limbal epithelial stem cells following corneal epithelial debridement.

    FoxC1 activates limbal epithelial stem cells following corneal epithelial debridement.
    Yang W, Lee SK, Lehmann OJ, Wu Z, Hiriyanna S, Swaroop A, Lavker RM, Peng H, Kume T.,

    08/28/2023
    Spectrum of white matter abnormalities associated with FOXC1-related disorders in two unrelated cases.

    Spectrum of white matter abnormalities associated with FOXC1-related disorders in two unrelated cases.
    Tabassum T, Maria Daniela D, La Piana R.

    06/22/2023
    LCK, FOXC1 and hsa-miR-146a-5p as potential immune effector molecules associated with rheumatoid arthritis.

    LCK, FOXC1 and hsa-miR-146a-5p as potential immune effector molecules associated with rheumatoid arthritis.
    Chen X, Xie L, Jiang Y, Zhang R, Wu W.

    02/4/2023
    Genotype-phenotype association of PITX2 and FOXC1 in Axenfeld-Rieger syndrome.

    Genotype-phenotype association of PITX2 and FOXC1 in Axenfeld-Rieger syndrome.
    Zhou L, Wang X, An J, Zhang Y, He M, Tang L.

    01/21/2023
    FOXC1mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblastlike synoviocytes in rheumatoid arthritis via NFkappaB signaling pathway.

    FOXC1‑mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast‑like synoviocytes in rheumatoid arthritis via NF‑κB signaling pathway.
    Wei Y, Huang X, Ma Y, Dai L., Free PMC Article

    08/20/2022
    FOXC1.

    FOXC1.
    Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W.

    12/2/2022
    Comparison of Anterior Segment Abnormalities in Individuals With FOXC1 and PITX2 Variants.

    Comparison of Anterior Segment Abnormalities in Individuals With FOXC1 and PITX2 Variants.
    Prem Senthil M, Knight LSW, Taranath D, Mackey DA, Ruddle JB, Chiang MY, Siggs OM, Souzeau E, Craig JE., Free PMC Article

    07/23/2022
    Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute Myeloid Leukemia Patients.

    Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute Myeloid Leukemia Patients.
    Nabawy SM, Refaat LA, Naser-Aldin HM, Rashed RA., Free PMC Article

    06/11/2022
    Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia.

    Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia.
    Wang Y, Ma X, Huang J, Yang X, Kang M, Sun X, Li H, Wu Y, Zhang H, Zhu Y, Xue Y, Fang Y., Free PMC Article

    05/14/2022
    Variable Anterior Segment Dysgenesis and Cardiac Anomalies Caused by a Novel Truncating Variant of FOXC1.

    Variable Anterior Segment Dysgenesis and Cardiac Anomalies Caused by a Novel Truncating Variant of FOXC1.
    Ahmed MR, Sethna S, Krueger LA, Yang MB, Hufnagel RB., Free PMC Article

    05/7/2022
    Identification and functional study of FOXC1 variants in Chinese families with glaucoma.

    Identification and functional study of FOXC1 variants in Chinese families with glaucoma.
    Wang X, Liu X, Li Y, Yang B, Sun X, Yang P, Zhong Z, Chen J.

    04/16/2022
    USP28 promotes aerobic glycolysis of colorectal cancer by increasing stability of FOXC1.

    USP28 promotes aerobic glycolysis of colorectal cancer by increasing stability of FOXC1.
    Liu Z, Chen M, Xu X, Zhang L, Pan Y, Chen D.

    03/19/2022
    Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis.

    Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis.
    Li M, Zhu L, Liu J, Huang H, Guo H, Wang L, Li L, Gu S, Tan J, Zhong J, Wang B, Mao Z, Fan Y, Liu C, Yuan J, Ouyang H., Free PMC Article

    03/5/2022
    Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

    Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
    Simeoni F, Romero-Camarero I, Camera F, Amaral FMR, Sinclair OJ, Papachristou EK, Spencer GJ, Lie-A-Ling M, Lacaud G, Wiseman DH, Carroll JS, Somervaille TCP., Free PMC Article

    02/19/2022
    [FOXC1 Knockdown Reverses Gefitinib Resistance in Non-small Cell Lung Cancer].

    [FOXC1 Knockdown Reverses Gefitinib Resistance in Non-small Cell Lung Cancer].
    Peng C, Li P, Yang M, Chen D, Huang Y., Free PMC Article

    02/5/2022
    miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1.

    miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1.
    Li D, Zhang Y, Li Y, Wang X, Wang F, Du J, Zhang H, Shi H, Wang Y, Gao Y, Feng Y, Yan J, Xue Y, Yang Y, Zhang J., Free PMC Article

    01/22/2022
    Knockdown of HCG18 Inhibits Cell Viability, Migration and Invasion in Pediatric Osteosarcoma by Targeting miR-188-5p/FOXC1 Axis.

    Knockdown of HCG18 Inhibits Cell Viability, Migration and Invasion in Pediatric Osteosarcoma by Targeting miR-188-5p/FOXC1 Axis.
    Zhao Z, Chen J, Xia D.

    01/8/2022
    MicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pathway.

    MicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pathway.
    Zhou X, Chen Z, Pei L, Sun J., Free PMC Article

    11/27/2021
    MicroRNA-495/TGF-beta/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells.

    MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells.
    Kumar U, Hu Y, Masrour N, Castellanos-Uribe M, Harrod A, May ST, Ali S, Speirs V, Coombes RC, Yagüe E.

    11/22/2021
    EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers.

    EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers.
    Zheng XJ, Li W, Yi J, Liu JY, Ren LW, Zhu XM, Liu SW, Wang JH, Du GH., Free PMC Article

    10/30/2021
    Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes.

    Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes.
    Yang J, Zhang D, Motojima M, Kume T, Hou Q, Pan Y, Duan A, Zhang M, Jiang S, Hou J, Shi J, Qin Z, Liu Z., Free PMC Article

    10/9/2021
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