| USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells. | USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells.
Zhong B, Zhu Q, Wang L, Wang F, Zheng Y, Lin S, Cheng X. | 07/17/2023 |
| Downregulation of USP33 inhibits Slit/Robo signaling pathway and is associated with poor patient survival of glioma. | Downregulation of USP33 inhibits Slit/Robo signaling pathway and is associated with poor patient survival of glioma.
Han PP, Zhang GQ, Li L, Yue L. | 02/14/2023 |
| USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells. | USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells.
Zhang A, Huang Z, Tao W, Zhai K, Wu Q, Rich JN, Zhou W, Bao S., Free PMC Article | 04/16/2022 |
| Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma. | Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma.
Wang H, Liu Z, Sun Z, Zhou D, Mao H, Deng G., Free PMC Article | 04/16/2022 |
| Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins. | Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.
Culver JA, Mariappan M., Free PMC Article | 10/2/2021 |
| USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy. | USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.
Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, Li Y, Balajee AS, Zhao Y., Free PMC Article | 06/12/2021 |
| SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia. | SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia.
Mishra R, Banerjea AC., Free PMC Article | 05/15/2021 |
| USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma. | USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma.
Gan Q, Shao J, Cao Y, Lei J, Xie P, Ge J, Hu G. | 11/21/2020 |
| Our study reveals the inhibitory function of Slit-Robo signalling in gastric cancer (GC) and uncovers a role of USP33 in suppressing cancer cell migration and epithelial-mesenchymal transition by enhancing Slit2-Robo1 signalling. USP33 represents a feasible choice as a prognostic biomarker for GC. | Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT.
Xia Y, Wang L, Xu Z, Kong R, Wang F, Yin K, Xu J, Li B, He Z, Wang L, Xu H, Zhang D, Yang L, Wu JY, Xu Z., Free PMC Article | 06/23/2019 |
| USP33 was downregulated in gastric adenocarcinoma. | Reduced Expression of Deubiquitinase USP33 Is Associated with Tumor Progression and Poor Prognosis of Gastric Adenocarcinoma.
Chen Y, Pang X, Ji L, Sun Y, Ji Y., Free PMC Article | 10/6/2018 |
| Fluorescence-activated cell sorting experiment found no significant effect of USP33 on cell cycle, whereas the apoptotic caspase proteins were activated by USP33-overexpression and the interaction between USP33 and Robo1 protein was identified, and knockdown of Robo1 enhancing the oncogenic effect upon USP33-knockdown, suggesting that USP33 may inhibit tumor progression through Robo1 signaling. | USP33 is a Biomarker of Disease Recurrence in Papillary Thyroid Carcinoma.
Jia M, Guo Y, Lu X. | 05/19/2018 |
| USP33 may indirectly regulate the degradation and recycling of CXCR4 through deubiquitinating beta-arrestin2, promoting colorectal tumor cell metastasis. | Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into β-arrestin-dependent ERK signaling.
Liu H, Zhang Q, Li K, Gong Z, Liu Z, Xu Y, Swaney MH, Xiao K, Chen Y., Free PMC Article | 02/24/2018 |
| the E3 ligase beta-TrCP regulates cellular USP33 levels by the ubiquitin-proteasomal proteolysis. | Deubiquitinase USP33 is negatively regulated by β-TrCP through ubiquitin-dependent proteolysis.
Cheng Q, Yuan Y, Li L, Guo T, Miao Y, Ren Y, Liu J, Feng Q, Wang X, Zhao P, Zuo Y, Qian L, Zhang L, Zheng H. | 09/30/2017 |
| Data show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression. | Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E., Free PMC Article | 09/10/2016 |
| Data show that ubiquitin specific peptidase 33 (USP33) mediates nerve tissue proteins Slit-Robo signaling in lung cancer cell migration. | USP33, a new player in lung cancer, mediates Slit-Robo signaling.
Wen P, Kong R, Liu J, Zhu L, Chen X, Li X, Nie Y, Wu K, Wu JY., Free PMC Article | 05/16/2015 |
| USP33 as a previously unknown tumor-suppressing gene. | USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration.
Huang Z, Wen P, Kong R, Cheng H, Zhang B, Quan C, Bian Z, Chen M, Zhang Z, Chen X, Du X, Liu J, Zhu L, Fushimi K, Hua D, Wu JY., Free PMC Article | 04/18/2015 |
| Knockdown or chemical inhibition of p97 causes robust accumulation of USP33 due to inhibition of its degradation | Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.
Chan NC, den Besten W, Sweredoski MJ, Hess S, Deshaies RJ, Chan DC., Free PMC Article | 10/4/2014 |
| nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 to RALB-positive vesicles | The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Simicek M, Lievens S, Laga M, Guzenko D, Aushev VN, Kalev P, Baietti MF, Strelkov SV, Gevaert K, Tavernier J, Sablina AA. | 12/21/2013 |
| using human cells, identification of a new mechanism for the regulation of centrosome duplication that requires USP33, a deubiquitinating enzyme that is able to regulate CP110 levels | USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.
Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD., Free PMC Article | 04/20/2013 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility.
Meulenbelt I, Bos SD, Chapman K, van der Breggen R, Houwing-Duistermaat JJ, Kremer D, Kloppenburg M, Carr A, Tsezou A, González A, Loughlin J, Slagboom PE. | 09/15/2010 |
| Data uncover a previously unknown function of USP33 and reveal a new player in Slit-Robo signaling in cancer cell migration. | Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.
Yuasa-Kawada J, Kinoshita-Kawada M, Rao Y, Wu JY., Free PMC Article | 01/21/2010 |
| Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling | Midline crossing and Slit responsiveness of commissural axons require USP33.
Yuasa-Kawada J, Kinoshita-Kawada M, Wu G, Rao Y, Wu JY., Free PMC Article | 01/21/2010 |
| USPs 20 and 33 serve as novel regulators that dictate both post-endocytic sorting as well as the intensity and extent of beta(2)AR signalling from the cell surface. | The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.
Berthouze M, Venkataramanan V, Li Y, Shenoy SK., Free PMC Article | 01/21/2010 |
| USP33 and Mdm2 function reciprocally and favor respectively the stability or lability of the receptor beta-arrestin complex | Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.
Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, Lefkowitz RJ., Free PMC Article | 01/21/2010 |
| VDU1 was identified as a protein partner of hSP56. | Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner.
Jeong JY, Wang Y, Sytkowski AJ. | 01/21/2010 |