| SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma. | SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma.
Leeksma AC, Derks IAM, Garrick B, Jongejan A, Colombo M, Bloedjes T, Trowe T, Leisten JC, Howarth M, Malek M, Mortensen DS, Blease K, Groza MC, Narla RK, Loos R, Kersten MJ, Moerland PD, Guikema JEJ, Kater AP, Eldering E, Filvaroff EH., Free PMC Article | 02/13/2023 |
| Large-scale genomic sequencing reveals adaptive opportunity of targeting mutated-PI3Kalpha in early and advanced HER2-positive breast cancer. | Large-scale genomic sequencing reveals adaptive opportunity of targeting mutated-PI3Kα in early and advanced HER2-positive breast cancer.
Guo LW, Li XG, Yang YS, Lu XX, Han XC, Lang GT, Chen L, Shao ZM, Hu X., Free PMC Article | 03/5/2022 |
| SMG1 and CDK12 Link DeltaNp63alpha Phosphorylation to RNA Surveillance in Keratinocytes. | SMG1 and CDK12 Link ΔNp63α Phosphorylation to RNA Surveillance in Keratinocytes.
Bamberger C, Pankow S, Yates JR 3rd., Free PMC Article | 03/5/2022 |
| Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. | Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity.
Langer LM, Gat Y, Bonneau F, Conti E., Free PMC Article | 03/20/2021 |
| Cryo-EM structure of SMG1-SMG8-SMG9 complex. | Cryo-EM structure of SMG1-SMG8-SMG9 complex.
Zhu L, Li L, Qi Y, Yu Z, Xu Y., Free PMC Article | 09/19/2020 |
| MicroRNA-18a promotes cancer progression through SMG1 suppression and mTOR pathway activation in nasopharyngeal carcinoma. | MicroRNA-18a promotes cancer progression through SMG1 suppression and mTOR pathway activation in nasopharyngeal carcinoma.
Mai S, Xiao R, Shi L, Zhou X, Yang T, Zhang M, Weng N, Zhao X, Wang R, Liu J, Sun R, Qin H, Wang H., Free PMC Article | 08/29/2020 |
| SMG1 variants c.4249A>G and c.103G>A are associated with pancreatic cancer in large study | A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene.
Wong C, Chen F, Alirezaie N, Wang Y, Cuggia A, Borgida A, Holter S, Lenko T, Domecq C, Alzheimer’s Disease Neuroimaging Initiative, Petersen GM, Syngal S, Brand R, Rustgi AK, Cote ML, Stoffel E, Olson SH, Roberts NJ, Akbari MR, Majewski J, Klein AP, Greenwood CMT, Gallinger S, Zogopoulos G., Free PMC Article | 03/7/2020 |
| This study reports the 3.45-A resolution cryo-EM structure of human SMG1-SMG8-SMG9, a phosphatidylinositol-3-kinase (PI(3)K)-related protein kinase (PIKK) complex central to messenger RNA surveillance. | InsP(6) binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex.
Gat Y, Schuller JM, Lingaraju M, Weyher E, Bonneau F, Strauss M, Murray PJ, Conti E. | 02/29/2020 |
| SMG-1 is a target of the oncomiRs, miR-192 and -215, and that its downregulation is associated with tumor size and serosal invasion of gastric cancer (GC). SMG-1 appears to mediate at least some of the oncogenic function of miR-192 and -215 by participating in epithelial-mesenchymal transition, triggered by activation of the Wnt pathway in GC. | SMG-1 inhibition by miR-192/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling.
Zhang X, Peng Y, Huang Y, Yang M, Yan R, Zhao Y, Cheng Y, Liu X, Deng S, Feng X, Lin H, Yu H, Chen S, Zhao Z, Li S, Li K, Wang L, Wei Y, He Z, Fan X, Meltzer SJ, Li S, Jin Z., Free PMC Article | 06/29/2019 |
| Because SMG-1-p53 signaling attenuates production of mitochondrial ROS. | SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia.
Resseguie EA, Brookes PS, O'Reilly MA., Free PMC Article | 06/30/2018 |
| ionizing radiation (IR) inhibits the activity of SMG1, a phosphoinositide-3-kinase-like kinase family member, reducing the binding of SMG1 to a specific region near exon 9 of p53 precursor mRNA and promoting the binding of ribosomal protein L26 (RPL26) to p53 pre-mRNA | Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.
Chen J, Crutchley J, Zhang D, Owzar K, Kastan MB., Free PMC Article | 03/31/2018 |
| Knock down of the expression of SMG-1 inhibited tumor cell proliferation and induced the chemosensitivity of pancreatic cancer cells in vitro. | Overexpression of serine/threonine-protein kinase-1 in pancreatic cancer tissue: Serine/threonine-protein kinase-1 knockdown increases the chemosensitivity of pancreatic cancer cells.
Wang Q, Xu D, Han C, Tu M, Du Q, Zhang J, Zhu Y, Xu L. | 01/16/2016 |
| SMG1 was hypermethylated in 66% of AML samples compared with none in controls. mTOR expression level was negatively correlated to SMG1 expression in AML patients which indicated that SMG1 and mTOR maybe act antagonistically to regulate AML cell growth. | SMG1 acts as a novel potential tumor suppressor with epigenetic inactivation in acute myeloid leukemia.
Du Y, Lu F, Li P, Ye J, Ji M, Ma D, Ji C., Free PMC Article | 06/27/2015 |
| A genome-wide RNA interference screen Hepatocellular carcinoma cell lines revealed the role of suppressor of SMG-1 as determinant of sorafenib resistance. | Genetic screen identifies suppressor of morphogenesis in genitalia-1 (SMG-1) as a modulator of sorafenib resistance in hepatocellular carcinoma cell lines.
Nam SW, Park KC, Yang KJ, Lee B, Kim SW. | 06/20/2015 |
| SMG1 regulates NMD by recruiting UPF1 and UPF2 to distinct nearby positions, and can form a complex with UPF2 in vivo in an UPF1-independent manner. | Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.
Melero R, Uchiyama A, Castaño R, Kataoka N, Kurosawa H, Ohno S, Yamashita A, Llorca O. | 04/4/2015 |
| We conclude that SMG-1 is downregulated in HCC and may represent a promising biomarker for predicting the prognosis of HCC, including the prognosis of early-stage patients. | Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma.
Han LL, Nan HC, Tian T, Guo H, Hu TH, Wang WJ, Ma JQ, Jiang LL, Guo QQ, Yang CC, Kang XM, Liu Y, Gao Y, Liu QL, Nan KJ. | 12/20/2014 |
| Novel role for SMG-1 is identified in regulating Cdc25A and suppressing oncogenic CDK2 driven proliferation, confirming SMG-1 as a tumor suppressor. | SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways.
Gubanova E, Issaeva N, Gokturk C, Djureinovic T, Helleday T., Free PMC Article | 09/13/2014 |
| This study demonstrated the quantitative regulation of Upf1 and Upf2 proteins by ubiquitin-proteasome system and SMG1. | Proteasome inhibitors and knockdown of SMG1 cause accumulation of Upf1 and Upf2 in human cells.
Zhao X, Nogawa A, Matsunaga T, Takegami T, Nakagawa H, Ishigaki Y. | 08/23/2014 |
| SMG1 protein levels were significantly reduced in brain. | SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.
Henderson-Smith A, Chow D, Meechoovet B, Aziz M, Jacobson SA, Shill HA, Sabbagh MN, Caviness JN, Adler CH, Driver-Dunckley ED, Beach TG, Yin H, Dunckley T., Free PMC Article | 08/9/2014 |
| Downregulation of SMG1 causes the reduction in the level of Upf1 phosphorylation and delays adipogenesis, suggesting the functional involvement of SMG1 in adipogenesis via SMD. | SMG1 regulates adipogenesis via targeting of staufen1-mediated mRNA decay.
Cho H, Han S, Park OH, Kim YK. | 02/15/2014 |
| Data indicate that down-regulation of SMG1 expression is mediated by miRNA-125 binding to a microRNA response element in the 3' untranslated region of SMG1 mRNA, which leads to degradation of the SMG1 mRNA. | MicroRNA 125 represses nonsense-mediated mRNA decay by regulating SMG1 expression.
Wang G, Jiang B, Jia C, Chai B, Liang A. | 08/31/2013 |
| the inflammation observed in Smg1 haploinsufficiency contributes to susceptibility to cancer, and Smg1-deficient animals represent a model of inflammation-enhanced cancer development | Smg1 haploinsufficiency predisposes to tumor formation and inflammation.
Roberts TL, Ho U, Luff J, Lee CS, Apte SH, MacDonald KP, Raggat LJ, Pettit AR, Morrow CA, Waters MJ, Chen P, Woods RG, Thomas GP, St Pierre L, Farah CS, Clarke RA, Brown JA, Lavin MF., Free PMC Article | 03/23/2013 |
| Levels of SMG-1 expression negatively correlated with HPV status in cancer cell lines and tumors. | Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.
Gubanova E, Brown B, Ivanov SV, Helleday T, Mills GB, Yarbrough WG, Issaeva N., Free PMC Article | 06/30/2012 |
| Hyperglycemia (both 10 and 20 mM)-treated monocyte showed up-regulated phosphorylation of p101 and p110gamma subunits of PI-3 kinase in comparison to 5 mM glucose. | Effect of hyperglycemia on human monocyte activation.
Nandy D, Janardhanan R, Mukhopadhyay D, Basu A., Free PMC Article | 02/11/2012 |
| stress granule formation appears more complex than originally envisaged and hSMG-1 plays a central role in this process. | A novel role for hSMG-1 in stress granule formation.
Brown JA, Roberts TL, Richards R, Woods R, Birrell G, Lim YC, Ohno S, Yamashita A, Abraham RT, Gueven N, Lavin MF., Free PMC Article | 12/24/2011 |