| CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins. | CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
Chen M, Li J, Zhang L, Wang L, Cheng C, Ji H, Altilia S, Ding X, Cai G, Altomare D, Shtutman M, Byrum SD, Mackintosh SG, Feoktistov A, Soshnikova N, Mogila VA, Tatarskiy V, Erokhin M, Chetverina D, Prawira A, Ni Y, Urban S, McInnes C, Broude EV, Roninson IB., Free PMC Article | 08/16/2023 |
| CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF. | CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.
Dannappel MV, Zhu D, Sun X, Chua HK, Poppelaars M, Suehiro M, Khadka S, Lim Kam Sian TC, Sooraj D, Loi M, Gao H, Croagh D, Daly RJ, Faridi P, Boyer TG, Firestein R., Free PMC Article | 10/22/2022 |
| Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer. | Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.
Offermann A, Joerg V, Becker F, Roesch MC, Kang D, Lemster AL, Tharun L, Behrends J, Merseburger AS, Culig Z, Sailer V, Brägelmann J, Kirfel J, Perner S. | 05/7/2022 |
| Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis. | Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis.
Fan L, Lei H, Lin Y, Zhou Z, Li J, Wu A, Shu G, Roger S, Yin G., Free PMC Article | 05/7/2022 |
| CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21. | CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21.
Zhang Z, Lu Y, Qi Y, Xu Y, Wang S, Chen F, Shen M, Chen M, Chen N, Yang L, Chen S, Wang F, Su Y, Hu M, Wang J. | 04/16/2022 |
| A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms. | A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms.
Yang S, Yu W, Chen Q, Wang X., Free PMC Article | 12/4/2021 |
| Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma. | Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma.
Cai X, Deng J, Zhou J, Cai H, Chen Z., Free PMC Article | 10/23/2021 |
| CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants. | CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants.
Zarate YA, Uehara T, Abe K, Oginuma M, Harako S, Ishitani S, Lehesjoki AE, Bierhals T, Kloth K, Ehmke N, Horn D, Holtgrewe M, Anderson K, Viskochil D, Edgar-Zarate CL, Sacoto MJG, Schnur RE, Morrow MM, Sanchez-Valle A, Pappas J, Rabin R, Muona M, Anttonen AK, Platzer K, Luppe J, Gburek-Augustat J, Kaname T, Okamoto N, Mizuno S, Kaido Y, Ohkuma Y, Hirose Y, Ishitani T, Kosaki K. | 08/7/2021 |
| ISOC1 promotes the proliferation of gastric cancer cells by positively regulating CDK19. | ISOC1 promotes the proliferation of gastric cancer cells by positively regulating CDK19.
Zhao JQ, Li XN, Fu LP, Zhang N, Cai JH. | 07/3/2021 |
| CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC. | CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC.
Paulsen FO, Idel C, Ribbat-Idel J, Kuppler P, Klapper L, Rades D, Bruchhage KL, Wollenberg B, Brägelmann J, Perner S, Offermann A., Free PMC Article | 02/27/2021 |
| Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection. | Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.
Butler M, Chotiwan N, Brewster CD, DiLisio JE, Ackart DF, Podell BK, Basaraba RJ, Perera R, Quackenbush SL, Rovnak J., Free PMC Article | 02/20/2021 |
| findings demonstrate that human CDK19 fully replaces the function of Cdk8 in the fly, the human disease-associated CDK19 variants behave as strong loss-of-function variants, and deleterious CDK19 variants underlie a syndromic neurodevelopmental disorder | De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy.
Chung HL, Mao X, Wang H, Park YJ, Marcogliese PC, Rosenfeld JA, Burrage LC, Liu P, Murdock DR, Yamamoto S, Wangler MF, Undiagnosed Diseases Network, Chao HT, Long H, Feng L, Bacino CA, Bellen HJ, Xiao B., Free PMC Article | 08/1/2020 |
| siRNA knockdown of CDK8 or CDK19 had no effect on HIV transcription. This result was confirmed using CDK8 or CDK19 inhibitors, Cortistatin A and Senexin A. these results indicate that CDK8 or CDK19 are not required for HIV transcription. | HIV Transcription Is Independent of Mediator Kinases.
Cary DC, Rheinberger M, Rojc A, Peterlin BM., Free PMC Article | 07/11/2020 |
| Study highlights CDK19 as a prognostic biomarker for prostate cancer (PCa) predicting disease recurrence independently from established prognostic markers. Furthermore, the results support the recently identified highly relevant role of CDK19 and CDK8 for PCa progression. | Increased mediator complex subunit CDK19 expression associates with aggressive prostate cancer.
Becker F, Joerg V, Hupe MC, Roth D, Krupar R, Lubczyk V, Kuefer R, Sailer V, Duensing S, Kirfel J, Merseburger AS, Brägelmann J, Perner S, Offermann A. | 02/22/2020 |
| lncRNA CASC2 activated paclitaxel resistance in breast cancer through regulation of miR-18a-5p/CDK19 | Long noncoding RNA CASC2 promotes paclitaxel resistance in breast cancer through regulation of miR-18a-5p/CDK19.
Zheng P, Dong L, Zhang B, Dai J, Zhang Y, Wang Y, Qin S. | 12/7/2019 |
| The CDK19 may enable metabolic and transcriptional reprogramming through enhancers and chromatin looping. | Regulatory functions of the Mediator kinases CDK8 and CDK19.
Fant CB, Taatjes DJ., Free PMC Article | 05/4/2019 |
| These findings confirm that UF-linked mutations in MED12 disrupt composite Mediator-associated kinase activity and identify CDK8/19 as prospective therapeutic targets in uterine fibroids. | Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
Park MJ, Shen H, Spaeth JM, Tolvanen JH, Failor C, Knudtson JF, McLaughlin J, Halder SK, Yang Q, Bulun SE, Al-Hendy A, Schenken RS, Aaltonen LA, Boyer TG., Free PMC Article | 04/13/2019 |
| Genes coregulated by CDK8/19 and NFkappaB include IL8, CXCL1, and CXCL2. | CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.
Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB., Free PMC Article | 06/9/2018 |
| Moreover, it identified CDK19 and CDK8 to be specifically overexpressed during prostate cancer progression, highlighting their potential as novel therapeutic targets in advanced prostate cancer. | Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.
Brägelmann J, Klümper N, Offermann A, von Mässenhausen A, Böhm D, Deng M, Queisser A, Sanders C, Syring I, Merseburger AS, Vogel W, Sievers E, Vlasic I, Carlsson J, Andrén O, Brossart P, Duensing S, Svensson MA, Adler D, Kirfel J, Perner S. | 02/10/2018 |
| High CDK19 expression is associated with osteosarcoma. | A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.
Audetat KA, Galbraith MD, Odell AT, Lee T, Pandey A, Espinosa JM, Dowell RD, Taatjes DJ., Free PMC Article | 09/16/2017 |
| On stimulation of TLR9, CDK8/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB and C/EBPbeta. | Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.
Yamamoto S, Hagihara T, Horiuchi Y, Okui A, Wani S, Yoshida T, Inoue T, Tanaka A, Ito T, Hirose Y, Ohkuma Y. | 04/1/2017 |
| Data suggest that, during neurogenesis, Mediator complex cyclin-dependent kinases (CDK8, CDK19) interact directly with PRC2 (polycomb repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2), as well as SUZ12 (suppressor of zeste 12 homolog). | Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.
Fukasawa R, Iida S, Tsutsui T, Hirose Y, Ohkuma Y. | 07/30/2016 |
| Mediator-associated kinases CDK8 and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML) cells | Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
Pelish HE, Liau BB, Nitulescu II, Tangpeerachaikul A, Poss ZC, Da Silva DH, Caruso BT, Arefolov A, Fadeyi O, Christie AL, Du K, Banka D, Schneider EV, Jestel A, Zou G, Si C, Ebmeier CC, Bronson RT, Krivtsov AV, Myers AG, Kohl NE, Kung AL, Armstrong SA, Lemieux ME, Taatjes DJ, Shair MD., Free PMC Article | 04/2/2016 |
| Microarrays identified target genes for each CDK, and we selected six genes: two target genes of CDK8, two target genes of CDK19 and two genes that were targets for both. | Identification of target genes for the CDK subunits of the Mediator complex.
Tsutsui T, Fukasawa R, Tanaka A, Hirose Y, Ohkuma Y. | 08/29/2015 |
| CDK8 and CDK19, individually interact with PRMT5 and WDR77, and their interactions with PRMT5 cause transcriptional repression of C/EBPbeta target genes. | Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.
Tsutsui T, Fukasawa R, Shinmyouzu K, Nakagawa R, Tobe K, Tanaka A, Ohkuma Y., Free PMC Article | 11/30/2013 |