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    FLG filaggrin [ Homo sapiens (human) ]

    Gene ID: 2312, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Evaluation of OVOL1 and Filaggrin immunohistochemical expression and clinical relevance in psoriasis.

    Evaluation of OVOL1 and Filaggrin immunohistochemical expression and clinical relevance in psoriasis.
    Hemida AS, Hammam MA, Swilam AA, Shehata WA., Free PMC Article

    07/29/2024
    Influence of household pet ownership and filaggrin loss-of-function mutations on eczema prevalence in children: A birth cohort study.

    Influence of household pet ownership and filaggrin loss-of-function mutations on eczema prevalence in children: A birth cohort study.
    Toyokuni K, Yamamoto-Hanada K, Yang L, Hagino K, Harama D, Omori M, Matsumoto Y, Suzuki D, Umezawa K, Takada K, Shimada M, Hirai S, Ishikawa F, Hamaguchi S, Saito-Abe M, Sato M, Miyaji Y, Kabashima S, Fukuie T, Noguchi E, Suzuki K, Ohya Y.

    07/10/2024
    Immunolabeling for filaggrin and acidic keratins in the granular layer of mammalian epidermis indicates that an acidic-basic interaction is involved in cornification.

    Immunolabeling for filaggrin and acidic keratins in the granular layer of mammalian epidermis indicates that an acidic-basic interaction is involved in cornification.
    Alibardi L.

    06/28/2024
    Rare Filaggrin Variants Are Associated with Pustular Skin Diseases in Asians.

    Rare Filaggrin Variants Are Associated with Pustular Skin Diseases in Asians.
    Lo Piccolo L, Wongkummool W, Jantaree P, Daroontum T, Chaowattanapanit S, Choonhakarn C, Amornpinyo W, Chaiwarith R, Kiratikanon S, Rujiwetpongstorn R, Tovanabutra N, Chiewchanvit S, Ngamphiw C, Intachai W, Kantaputra P, Chuamanochan M., Free PMC Article

    06/27/2024
    Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort.

    Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort.
    Virolainen SJ, Satish L, Biagini JM, Chaib H, Chang WC, Dexheimer PJ, Dixon MR, Dunn K, Fletcher D, Forney C, Granitto M, Hestand MS, Hurd M, Kauffman K, Lawson L, Martin LJ, Peña LD, Phelan KJ, Shook M, Weirauch MT, Khurana Hershey GK, Kottyan LC., Free PMC Article

    05/10/2024
    Association between filaggrin gene mutations and the clinical features of molluscum contagiosum: The Yamanashi Adjunct Study of the Japan Environment and Children's Study.

    Association between filaggrin gene mutations and the clinical features of molluscum contagiosum: The Yamanashi Adjunct Study of the Japan Environment and Children's Study.
    Kojima R, Miyake K, Shinohara R, Kushima M, Yui H, Otawa S, Horiuchi S, Yokomichi H, Akiyama Y, Ooka T, Yamagata Z, Yamanashi Adjunct Study of the Japan Environment and Children's Study Group., Free PMC Article

    04/5/2024
    Human filaggrin monomer does not seem to be a proteasome target.

    Human filaggrin monomer does not seem to be a proteasome target.
    Briot J, Arbey E, Goudounèche D, Bernard D, Simon M, Méchin MC.

    02/7/2024
    Temporal relationships between Staphylococcus aureus colonization, filaggrin expression, and pediatric atopic dermatitis.

    Temporal relationships between Staphylococcus aureus colonization, filaggrin expression, and pediatric atopic dermatitis.
    Dahal A, Chang WC, Almasri C, Johansson E, Hurd M, Velasquez V, Grashel B, Spagna D, Jenkins S, Morgan D, Satish L, Martin LJ, Biagini JM, Khurana Hershey GK.,

    01/16/2024
    Filaggrin gene polymorphisms in Indian children with atopic dermatitis: A cross-sectional multicentre study.

    Filaggrin gene polymorphisms in Indian children with atopic dermatitis: A cross-sectional multicentre study.
    Srinivas SM, Dhar S, Gowdra A, Saha A, Sundararajan L, Geetha TS, Banerjee R, Malakar R, Sil A, Lakshminarayana Shyam Prasad A.

    11/8/2023
    Filaggrin gene variants among Saudi patients with ichthyosis vulgaris.

    Filaggrin gene variants among Saudi patients with ichthyosis vulgaris.
    Alakloby OM, Almuqarrab F, Zschocke J, Schmuth M, Abdulkareem A, Alnutaifi K, Borgio F, Gruber R, Hennies HC., Free PMC Article

    11/1/2023
    Variants in the Gene Encoding Filaggrin Cause Autosomal-Dominant Symmetrical Acral Keratoderma.

    Variants in the Gene Encoding Filaggrin Cause Autosomal-Dominant Symmetrical Acral Keratoderma.
    Liu C, Han C, Liang J, Yang C, Wang Y, Chen P, Chen H, Lu H, Cai Y, Wang Q, Zhang X, Zeng K, Li C.

    06/26/2023
    Deep palmar phenotyping in atopic eczema: patterns associated with filaggrin variants, disease severity and barrier function in a South Asian population.

    Deep palmar phenotyping in atopic eczema: patterns associated with filaggrin variants, disease severity and barrier function in a South Asian population.
    Thomas BR, Tan XL, Van Duijvenboden S, Hogan SC, Hughes AJ, Tawfik SS, Dhoat S, Atkar R, Robinson EJ, Rahman SR, Rahman S, Ahmed RA, Begum R, Khanam H, Bourne EL, Wozniak EL, Mein CA, Kelsell DP, O'Toole EA.

    05/28/2023
    FLG mutations, eczema control, and respiratory symptom at one-year-old in early-onset atopic dermatitis infants (PACI-ON cohort study).

    FLG mutations, eczema control, and respiratory symptom at one-year-old in early-onset atopic dermatitis infants (PACI-ON cohort study).
    Kumagai F, Yamamoto-Hanada K, Saito-Abe M, Sato M, Ishikawa F, Irahara M, Miyaji Y, Kabashima S, Ohya Y, Akiyama M, Kono M.

    04/24/2023
    Biallelic mutations in FLG, TGM1, and STS genes segregated with different types of ichthyoses in eight families of Pakistani origin.

    Biallelic mutations in FLG, TGM1, and STS genes segregated with different types of ichthyoses in eight families of Pakistani origin.
    Khan N, Shah K, Fozia F, Khan SA, Muhammad N, Nasir A, Ahmad I, Rehman ZU, Jan A, Muhammad N, Khan S.

    04/20/2023
    Skin Barrier Function and Its Relationship With IL-17, IL-33, and Filaggrin in Malar Melasma.

    Skin Barrier Function and Its Relationship With IL-17, IL-33, and Filaggrin in Malar Melasma.
    Castanedo-Cázares JP, Cortés-García JD, Pérez-Coronado G, Hernández-Blanco D, Torres-Alvarez B.

    04/20/2023
    IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.

    IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.
    Kaymak T, Kaya B, Wuggenig P, Nuciforo S, Göldi A, Swiss EoE Cohort Study Group (SEECS), Oswald F, Roux J, Noti M, Melhem H, Hruz P, Niess JH., Free PMC Article

    04/7/2023
    Palmoplantar keratoderma as a clinical feature of pathogenic variants in the filaggrin gene.

    Palmoplantar keratoderma as a clinical feature of pathogenic variants in the filaggrin gene.
    Clabbers JMK, Bolling MC, Burms C, Vreeburg M, Lemmink HH, van den Akker PC, Steijlen PM, van Geel M, Gostyński AH.

    03/23/2023
    Prevalence of filaggrin gene polymorphisms (exon-3) in patients with atopic dermatitis in a multiracial Brazilian population.

    Prevalence of filaggrin gene polymorphisms (exon-3) in patients with atopic dermatitis in a multiracial Brazilian population.
    Laczynski CMM, Machado Filho CDS, Miot HA, Christofolini DM, Rodart IF, Criado PR., Free PMC Article

    02/24/2023
    FLG Gene Mutation Up-regulates the Abnormal Tumor Immune Response and Promotes the Progression of Prostate Cancer.

    FLG Gene Mutation Up-regulates the Abnormal Tumor Immune Response and Promotes the Progression of Prostate Cancer.
    Zhang P, An Z, Sun C, Xu Y, Zhang Z.

    10/29/2022
    The Skin and Nose Microbiome and Its Association with Filaggrin Gene Mutations in Pediatric Atopic Dermatitis.

    The Skin and Nose Microbiome and Its Association with Filaggrin Gene Mutations in Pediatric Atopic Dermatitis.
    van Mierlo MMF, Pardo LM, Fieten KB, van den Broek TJ, Schuren FHJ, van Geel M, Pasmans SGMA., Free PMC Article

    09/10/2022
    Barrier proteins and eosinophilic esophagitis in children: the role of E-cadherin and filaggrin.

    Barrier proteins and eosinophilic esophagitis in children: the role of E-cadherin and filaggrin.
    Rezende E, Faria M, Candelori I, Daud JS, Alves FA, Junior JC, Segundo GS.

    07/9/2022
    Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation.

    Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation.
    Oláh P, Szlávicz E, Kuchner M, Nemmer J, Zeeuwen P, Lefèvre-Utile A, Fyhrquist N, Prast-Nielsen S, Skoog T, Serra A, Rodríguez E, Raap U, Meller S, Gyulai R, Hupé P, Kere J, Levi-Schaffer F, Tsoka S, Alexander H, Nestle FO, Schröder JM, Weidinger S, van den Bogaard E, Soumelis V, Greco D, Barker J, Lauerma A, Ranki A, Andersson B, Alenius H, Homey B.

    06/25/2022
    Rare Variant Analysis and Molecular Dynamics Simulation in Alzheimer's Disease Identifies Exonic Variants in FLG.

    Rare Variant Analysis and Molecular Dynamics Simulation in Alzheimer's Disease Identifies Exonic Variants in FLG.
    Xiong W, Cai J, Li R, Wen C, Tan H, On Behalf Of The Alzheimer's Disease Neuroimaging Initiative Adni Database., Free PMC Article

    06/11/2022
    Filaggrin mutations in relation to skin barrier and atopic dermatitis in early infancy.

    Filaggrin mutations in relation to skin barrier and atopic dermatitis in early infancy.
    Hoyer A, Rehbinder EM, Färdig M, Asad S, Lødrup Carlsen KC, Endre KMA, Granum B, Haugen G, Hedlin G, Monceyron Jonassen C, Katayama S, Konradsen JR, Landrø L, LeBlanc M, Olsson Mägi CA, Rudi K, Skjerven HO, Staff AC, Vettukattil R, Bradley M, Nordlund B, Söderhäll C.

    04/30/2022
    Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children.

    Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children.
    Venter C, Palumbo MP, Sauder KA, Glueck DH, O'Mahony L, Yang I, Davidson EJ, Brough HA, Holloway JW, Fleischer DM, Ben-Abdallah M, Dabelea D., Free PMC Article

    04/16/2022
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