| MGCG regulates glioblastoma tumorigenicity via hnRNPK/ATG2A and promotes autophagy. | MGCG regulates glioblastoma tumorigenicity via hnRNPK/ATG2A and promotes autophagy.
Chu F, Wu P, Mu M, Hu S, Niu C., Free PMC Article | 07/20/2023 |
| Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation. | Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation.
Broadbent DG, Barnaba C, Perez GI, Schmidt JC., Free PMC Article | 05/15/2023 |
| HIF-1alpha-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation. | HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.
Li Q, Ni Y, Zhang L, Jiang R, Xu J, Yang H, Hu Y, Qiu J, Pu L, Tang J, Wang X., Free PMC Article | 03/5/2022 |
| A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis. | A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis.
Ghanbarpour A, Valverde DP, Melia TJ, Reinisch KM., Free PMC Article | 12/11/2021 |
| A conserved ATG2-GABARAP family interaction is critical for phagophore formation. | A conserved ATG2-GABARAP family interaction is critical for phagophore formation.
Bozic M, van den Bekerom L, Milne BA, Goodman N, Roberston L, Prescott AR, Macartney TJ, Dawe N, McEwan DG., Free PMC Article | 05/8/2021 |
| N-terminal fragment of ATG2A that supports lipid transfer in vitro is both necessary and fully sufficient to rescue blocked autophagosome biogenesis in ATG2A/ATG2B KO cells | ATG2 transports lipids to promote autophagosome biogenesis.
Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ., Free PMC Article | 04/11/2020 |
| Here, the authors demonstrate that human ATG2A is a lipid transfer protein. ATG2A can extract lipids from membrane vesicles and unload them to other vesicles. Lipid transfer by ATG2A is more efficient between tethered vesicles than between untethered vesicles. | The autophagic membrane tether ATG2A transfers lipids between membranes.
Maeda S, Otomo C, Otomo T., Free PMC Article | 02/29/2020 |
| Authors demonstrate that inhibition of autophagosome completion by Atg2A/B deletion accumulates immature autophagosomal membranes that promote non-canonical caspase-8 activation in response to nutrient starvation via an intracellular death-inducing signaling complex (iDISC). | Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis.
Tang Z, Takahashi Y, Chen C, Liu Y, He H, Tsotakos N, Serfass JM, Gebru MT, Chen H, Young MM, Wang HG., Free PMC Article | 07/28/2018 |
| Among polymorphisms identified in the present study, rs76974938 [C/T (D67N)] of C21orf59 and rs188780113 [G/A (R478C)] of ATG2A may be novel determinants of estimated glomerular filtration rate and chronic kidney disease or of the serum concentration of uric acid, respectively. | Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese by exome-wide association studies.
Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki T, Horibe H, Muramatsu M, Sawabe M, Fujiwara Y, Taniguchi Y, Obuchi S, Kawai H, Shinkai S, Mori S, Arai T, Tanaka M., Free PMC Article | 05/19/2018 |
| These data provide evidence for additional roles of Atg2A and Atg14L in the formation of early autophagosomal membranes and also in lipid metabolism. | Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells.
Pfisterer SG, Bakula D, Frickey T, Cezanne A, Brigger D, Tschan MP, Robenek H, Proikas-Cezanne T., Free PMC Article | 01/13/2018 |
| The N-terminal amino acids 1-198 and the C-terminal amino acids 1830-1938 are required for the localization to isolation membranes and lipid droplets, respectively. We also identified an amphipathic helix in ATG2A that is required for both its localization to organelles and autophagosome formation. | Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.
Tamura N, Nishimura T, Sakamaki Y, Koyama-Honda I, Yamamoto H, Mizushima N. | 12/23/2017 |
| Depletion of both Atg2A and Atg2B causes clustering of enlarged lipid droplets in an autophagy-independent manner. These data suggest that mammalian Atg2 proteins function both in autophagosome formation and regulation of lipid droplet morphology and dispersion. | Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.
Velikkakath AK, Nishimura T, Oita E, Ishihara N, Mizushima N., Free PMC Article | 11/24/2012 |
| human hAtg2A can not function in autophagy in yeast, however, it is recruited to the preautophagosomal structure | Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Δ strain.
Romanyuk D, Polak A, Maleszewska A, Sieńko M, Grynberg M, Żołądek T. | 04/7/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |