| Human Smc5/6 recognises transcription-generated positive DNA supercoils. | Human Smc5/6 recognises transcription-generated positive DNA supercoils.
Diman A, Panis G, Castrogiovanni C, Prados J, Baechler B, Strubin M., Free PMC Article | 09/14/2024 |
| The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress. | The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress.
Fingerman DF, O'Leary DR, Hansen AR, Tran T, Harris BR, DeWeerd RA, Hayer KE, Fan J, Chen E, Tennakoon M, Meroni A, Szeto JH, Devenport J, LaVigne D, Weitzman MD, Shalem O, Bednarski J, Vindigni A, Zhao X, Green AM., Free PMC Article | 08/2/2024 |
| The SMC5/6 complex: folding chromosomes back into shape when genomes take a break. | The SMC5/6 complex: folding chromosomes back into shape when genomes take a break.
Roy S, Adhikary H, D'Amours D., Free PMC Article | 03/27/2024 |
| The structural maintenance of chromosomes 5 is a possible biomarker for individualized treatment of colorectal cancer. | The structural maintenance of chromosomes 5 is a possible biomarker for individualized treatment of colorectal cancer.
Gong X, Tian X, Xie H, Li Z., Free PMC Article | 02/24/2023 |
| In-frame deletion of SMC5 related with the phenotype of primordial dwarfism, chromosomal instability and insulin resistance. | In-frame deletion of SMC5 related with the phenotype of primordial dwarfism, chromosomal instability and insulin resistance.
Zhu W, Shi Y, Zhang C, Peng Y, Wan Y, Xu Y, Liu X, Han B, Zhao S, Kuang Y, Song H, Qiao J., Free PMC Article | 01/14/2023 |
| Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency. | Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency.
Irwan ID, Bogerd HP, Cullen BR., Free PMC Article | 12/10/2022 |
| Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy. | Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.
Grange LJ, Reynolds JJ, Ullah F, Isidor B, Shearer RF, Latypova X, Baxley RM, Oliver AW, Ganesh A, Cooke SL, Jhujh SS, McNee GS, Hollingworth R, Higgs MR, Natsume T, Khan T, Martos-Moreno GÁ, Chupp S, Mathew CG, Parry D, Simpson MA, Nahavandi N, Yüksel Z, Drasdo M, Kron A, Vogt P, Jonasson A, Seth SA, Gonzaga-Jauregui C, Brigatti KW, Stegmann APA, Kanemaki M, Josifova D, Uchiyama Y, Oh Y, Morimoto A, Osaka H, Ammous Z, Argente J, Matsumoto N, Stumpel CTRM, Taylor AMR, Jackson AP, Bielinsky AK, Mailand N, Le Caignec C, Davis EE, Stewart GS., Free PMC Article | 11/12/2022 |
| The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr. | The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr.
Dupont L, Bloor S, Williamson JC, Cuesta SM, Shah R, Teixeira-Silva A, Naamati A, Greenwood EJD, Sarafianos SG, Matheson NJ, Lehner PJ., Free PMC Article | 10/23/2021 |
| Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase. | Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase.
Venegas AB, Natsume T, Kanemaki M, Hickson ID. | 05/15/2021 |
| SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability. | SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability.
Rossi F, Helbling-Leclerc A, Kawasumi R, Jegadesan NK, Xu X, Devulder P, Abe T, Takata M, Xu D, Rosselli F, Branzei D., Free PMC Article | 05/8/2021 |
| The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine. | The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine.
Serrano D, Cordero G, Kawamura R, Sverzhinsky A, Sarker M, Roy S, Malo C, Pascal JM, Marko JF, D'Amours D., Free PMC Article | 01/16/2021 |
| Molecular Insights into the Architecture of the Human SMC5/6 Complex. | Molecular Insights into the Architecture of the Human SMC5/6 Complex.
Adamus M, Lelkes E, Potesil D, Ganji SR, Kolesar P, Zabrady K, Zdrahal Z, Palecek JJ. | 01/2/2021 |
| Data found that SMC5 protein interaction with papillomavirus E2 is mediated by SMC6. the SMC5/6 complex was found to be involved in the papillomavirus genome maintenance. | The SMC5/6 Complex Interacts with the Papillomavirus E2 Protein and Influences Maintenance of Viral Episomal DNA.
Bentley P, Tan MJA, McBride AA, White EA, Howley PM., Free PMC Article | 09/7/2019 |
| Study shows that the SMC5/6-hinge complex binds preferentially to ssDNA and that this interaction is affected by both 'latch' and 'hub' mutations, suggesting a key role for these unique features in controlling DNA association by the SMC5/6 complex. | Specialized interfaces of Smc5/6 control hinge stability and DNA association.
Alt A, Dang HQ, Wells OS, Polo LM, Smith MA, McGregor GA, Welte T, Lehmann AR, Pearl LH, Murray JM, Oliver AW., Free PMC Article | 11/24/2018 |
| SMC5/6 knockdown rescued HBx-deficient hepatitis b virus replication in human hepatocytes. | Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication.
Murphy CM, Xu Y, Li F, Nio K, Reszka-Blanco N, Li X, Wu Y, Yu Y, Xiong Y, Su L., Free PMC Article | 11/18/2017 |
| High SMC5 protein is associated with hepatitis B. | The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection.
Niu C, Livingston CM, Li L, Beran RK, Daffis S, Ramakrishnan D, Burdette D, Peiser L, Salas E, Ramos H, Yu M, Cheng G, Strubin M, Delaney WE IV, Fletcher SP., Free PMC Article | 08/12/2017 |
| The SMC5/6 complex physically interacts with the DNA topoisomerase II alpha (TOP2A). | Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress.
Verver DE, Zheng Y, Speijer D, Hoebe R, Dekker HL, Repping S, Stap J, Hamer G., Free PMC Article | 04/15/2017 |
| results uncover a novel role for the Smc5/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription; by destroying this complex, HBx relieves the inhibition to allow productive hepatitis B virus gene expression | Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor.
Decorsière A, Mueller H, van Breugel PC, Abdul F, Gerossier L, Beran RK, Livingston CM, Niu C, Fletcher SP, Hantz O, Strubin M. | 04/16/2016 |
| Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome dynamics | The maintenance of chromosome structure: positioning and functioning of SMC complexes.
Jeppsson K, Kanno T, Shirahige K, Sjögren C. | 10/18/2014 |
| Depletion of Smc5 and Smc6 resulted in aberrant mitotic chromosome phenotypes that were accompanied by the abnormal distribution of topoisomerase IIalpha (topo IIalpha) and condensins and by chromosome segregation errors | Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.
Gallego-Paez LM, Tanaka H, Bando M, Takahashi M, Nozaki N, Nakato R, Shirahige K, Hirota T., Free PMC Article | 09/13/2014 |
| Studies indicate that Nse1 may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex. | The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.
Stephan AK, Kliszczak M, Morrison CG. | 12/3/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes.
Luedeke M, Linnert CM, Hofer MD, Surowy HM, Rinckleb AE, Hoegel J, Kuefer R, Rubin MA, Vogel W, Maier C. | 12/2/2009 |
| SMC5 is crucial for mitotic progression and maintenance of sister chromatid cohesion during mitosis. | SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.
Behlke-Steinert S, Touat-Todeschini L, Skoufias DA, Margolis RL. | 01/21/2010 |
| Nse1 RING-like motif is a protein-protein interaction domain required for Smc5-Smc6 holocomplex integrity and recruitment to, or retention at, DNA lesions | Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.
Pebernard S, Perry JJ, Tainer JA, Boddy MN., Free PMC Article | 01/21/2010 |