| Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1. | Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1.
Wang F, Liu Y, Dong Y, Zhao M, Huang H, Jin J, Fan L, Xiang R. | 05/9/2024 |
| Hydroxychloroquine sulfate: A novel treatment for lipin-1 deficiency? | Hydroxychloroquine sulfate: A novel treatment for lipin-1 deficiency?
Renard P, Caccavelli L, Legendre A, Tuchmann-Durand C, Balakirouchenane D, Blanchet B, Narjoz C, Straube M, Hubas A, Garros A, Mention K, Bednarek N, Goudin N, Broissand C, Schlatter J, Cisternino S, Cagnard N, van Endert P, Diana J, de Calbiac H, de Lonlay P. | 06/13/2023 |
| LPIN1 Is a Regulatory Factor Associated With Immune Response and Inflammation in Sepsis. | LPIN1 Is a Regulatory Factor Associated With Immune Response and Inflammation in Sepsis.
Dai W, Zheng P, Luo D, Xie Q, Liu F, Shao Q, Zhao N, Qian K., Free PMC Article | 04/16/2022 |
| Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis. | Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis.
Hamel Y, Mauvais FX, Madrange M, Renard P, Lebreton C, Nemazanyy I, Pellé O, Goudin N, Tang X, Rodero MP, Tuchmann-Durand C, Nusbaum P, Brindley DN, van Endert P, de Lonlay P., Free PMC Article | 03/5/2022 |
| NLIP and HAD-like Domains of Pah1 and Lipin 1 Phosphatidate Phosphatases Are Essential for Their Catalytic Activities. | NLIP and HAD-like Domains of Pah1 and Lipin 1 Phosphatidate Phosphatases Are Essential for Their Catalytic Activities.
Hsu WH, Huang YH, Chen PR, Hsieh LS., Free PMC Article | 11/22/2021 |
| Identification of lipidomic profiles associated with drug-resistant prostate cancer cells. | Identification of lipidomic profiles associated with drug-resistant prostate cancer cells.
Ingram LM, Finnerty MC, Mansoura M, Chou CW, Cummings BS., Free PMC Article | 11/6/2021 |
| Whole-exome sequencing reveals common and rare variants in immunologic and neurological genes implicated in achalasia. | Whole-exome sequencing reveals common and rare variants in immunologic and neurological genes implicated in achalasia.
Li Q, Chen W, Wang C, Liu Z, Gu Y, Xu X, Xu J, Jiang T, Xu M, Wang Y, Chen C, Zhong Y, Zhang Y, Yao L, Jin G, Hu Z, Zhou P., Free PMC Article | 09/4/2021 |
| Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. | Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Lu S, Lyu Z, Wang Z, Kou Y, Liu C, Li S, Hu M, Zhu H, Wang W, Zhang C, Kuan YS, Liu YW, Chen J, Tian J., Free PMC Article | 07/31/2021 |
| Lipid-associated PML structures assemble nuclear lipid droplets containing CCTalpha and Lipin1. | Lipid-associated PML structures assemble nuclear lipid droplets containing CCTα and Lipin1.
Lee J, Salsman J, Foster J, Dellaire G, Ridgway ND., Free PMC Article | 07/17/2021 |
| Use of dexamethasone in idiopathic, acute pediatric rhabdomyolysis. | Use of dexamethasone in idiopathic, acute pediatric rhabdomyolysis.
Summerlin ML, Regier DS, Fraser JL, Chapman KA, Kafashzadeh D, Billington C Jr, Kisling M, Grochowsky A, Ah Mew N, Shur N. | 07/10/2021 |
| Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity. | Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity.
Lutkewitte AJ, Finck BN., Free PMC Article | 07/3/2021 |
| UVB-dependent inhibition of lipin-1 protects against proinflammatory responses in human keratinocytes. | UVB-dependent inhibition of lipin-1 protects against proinflammatory responses in human keratinocytes.
Chae M, Son ED, Bae IH, Cho EG, Kim HJ, Jung JY., Free PMC Article | 07/3/2021 |
| Expression and clinicopathological significance of lipin-1 in human breast cancer and its association with p53 tumor suppressor gene. | Expression and clinicopathological significance of lipin-1 in human breast cancer and its association with p53 tumor suppressor gene.
Dinarvand N, Khanahmad H, Hakimian SM, Sheikhi A, Rashidi B, Bakhtiari H, Pourfarzam M. | 03/13/2021 |
| LPIN1 downregulation enhances anticancer activity of the novel HDAC/PI3K dual inhibitor FK-A11. | LPIN1 downregulation enhances anticancer activity of the novel HDAC/PI3K dual inhibitor FK-A11.
Imai H, Saijo K, Chikamatsu S, Kawamura Y, Ishioka C., Free PMC Article | 03/6/2021 |
| MiRNA-584 suppresses the progression of ovarian cancer by negatively regulating LPIN1. | MiRNA-584 suppresses the progression of ovarian cancer by negatively regulating LPIN1.
Yang L, Ma HL. | 02/13/2021 |
| Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy. | Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy.
Song L, Liu Z, Hu HH, Yang Y, Li TY, Lin ZZ, Ye J, Chen J, Huang X, Liu DT, Zhou J, Shi Y, Zhao H, Xie C, Chen L, Song E, Lin SY, Lin SC., Free PMC Article | 12/19/2020 |
| Study identified lipin1 to be involved in the production of a subset of cellular lipids, as a rate-limiting factor for HCV infection, and indicated that the enzymatic activity of lipin1 is required to build the membranous compartment dedicated to viral genome replication. Lipin1 is probably contributing to the formation of the viral replication machinery by locally providing certain lipids required. | Differential Roles of Lipin1 and Lipin2 in the Hepatitis C Virus Replication Cycle.
Castro V, Calvo G, Ávila-Pérez G, Dreux M, Gastaminza P., Free PMC Article | 07/25/2020 |
| Activation of endogenous PGAM5, promoted dephosphorylation and nuclear accumulation of Lipin-1 | Lipin-1 is a novel substrate of protein phosphatase PGAM5.
Okuno H, Okuzono H, Hayase A, Kumagai F, Tanii S, Hino N, Okada Y, Tachibana K, Doi T, Ishimoto K. | 11/9/2019 |
| we show lack of lipin-1 enhances the sensitivity of LUAD cells to cisplatin treatment. Our results suggest that lipin-1 is a potential target, alone or combined with other treatment, for lung cancer therapy. | Lipin-1 determines lung cancer cell survival and chemotherapy sensitivity by regulation of endoplasmic reticulum homeostasis and autophagy.
Fan X, Weng Y, Bai Y, Wang Z, Wang S, Zhu J, Zhang F., Free PMC Article | 11/2/2019 |
| This study provides the novel finding that exosomal miR-451a targets LPIN1 to inhibit hepatocellular tumorigenesis by regulating tumor cell apoptosis and angiogenesis. | Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1.
Zhao S, Li J, Zhang G, Wang Q, Wu C, Zhang Q, Wang H, Sun P, Xiang R, Yang S. | 06/29/2019 |
| The physical interaction between lipin1 and eEF1A1 was further affirmed in 293T cells transfected with 6-His tagged lipin1 and hepatocyte SMMC7721 cells by protein immunoprecipitation and immunofluorescence microscopy. Lipin1 also interacted with HIST1H2BK, which was confirmed in SMMC7721 cells by protein immunoprecipitation. | Mass spectrometry-based proteomic analysis reveals the interacting partners of lipin1.
Wang J, Wang S, Yan C, Deng Y, Huang Z, Shi P. | 06/22/2019 |
| findings advance our understanding of how phosphorylation of lipin 1beta phosphatidate phosphatase regulates its interaction with 14-3-3beta protein and intracellular localization and uncover a mechanism by which CKII regulates cellular physiology. | Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein.
Hennessy M, Granade ME, Hassaninasab A, Wang D, Kwiatek JM, Han GS, Harris TE, Carman GM., Free PMC Article | 05/4/2019 |
| Data indicate a general mechanism centered on Lipin-1 and SREBP that links the physical cell microenvironment to a key metabolic pathway. | Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP.
Romani P, Brian I, Santinon G, Pocaterra A, Audano M, Pedretti S, Mathieu S, Forcato M, Bicciato S, Manneville JB, Mitro N, Dupont S. | 04/20/2019 |
| Using surrogate models that recapitulate different aspects of HCV infection, we concluded that lipin1 is rate limiting for the generation of functional replicase complexes, in a step downstream primary translation that leads to early HCV RNA replication. | Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation.
Mingorance L, Castro V, Ávila-Pérez G, Calvo G, Rodriguez MJ, Carrascosa JL, Pérez-Del-Pulgar S, Forns X, Gastaminza P., Free PMC Article | 01/26/2019 |
| Normal human adipose tissue functions and differentiation has been found in rhabdomyolysis patients with biallelic LPIN1 inactivating mutations. | Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations.
Pelosi M, Testet E, Le Lay S, Dugail I, Tang X, Mabilleau G, Hamel Y, Madrange M, Blanc T, Odent T, McMullen TPW, Alfò M, Brindley DN, de Lonlay P., Free PMC Article | 07/21/2018 |