| Analysis and Investigation of Bioinformatics and Epigenetics Reveal the Underlying Mechanisms by which FLOT2 Modulates the Progression of Diffuse Large B-cell Lymphoma. | Analysis and Investigation of Bioinformatics and Epigenetics Reveal the Underlying Mechanisms by which FLOT2 Modulates the Progression of Diffuse Large B-cell Lymphoma.
Zhang Y, Chen Y, Guo Q, Zhang Y, Liu A. | 03/29/2024 |
| EFR3A: a new raft domain organizing protein? | EFR3A: a new raft domain organizing protein?
Trybus M, Hryniewicz-Jankowska A, Wójtowicz K, Trombik T, Czogalla A, Sikorski AF., Free PMC Article | 11/14/2023 |
| Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth. | Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.
Wisniewski DJ, Liyasova MS, Korrapati S, Zhang X, Ratnayake S, Chen Q, Gilbert SF, Catalano A, Voeller D, Meerzaman D, Guha U, Porat-Shliom N, Annunziata CM, Lipkowitz S., Free PMC Article | 02/4/2023 |
| FLOT2 Promotes the Proliferation and Epithelial-mesenchymal Transition of Cervical Cancer by Activating the MEK/ERK1/2 Pathway. | FLOT2 Promotes the Proliferation and Epithelial-mesenchymal Transition of Cervical Cancer by Activating the MEK/ERK1/2 Pathway.
Li Y, Dou S., Free PMC Article | 07/30/2022 |
| The differential role of the lipid raft-associated protein flotillin 2 for progression of myeloid leukemia. | The differential role of the lipid raft-associated protein flotillin 2 for progression of myeloid leukemia.
Kumar R, Pereira RS, Niemann J, Azimpour AI, Zanetti C, Karantanou C, Minka W, Minciacchi VR, Kowarz E, Meister M, Godavarthy PS, Maguer-Satta V, Lefort S, Wiercinska E, Bonig H, Marschalek R, Krause DS., Free PMC Article | 06/25/2022 |
| N6-methyladenosine Demethylase FTO Induces the Dysfunctions of Ovarian Granulosa Cells by Upregulating Flotillin 2. | N6-methyladenosine Demethylase FTO Induces the Dysfunctions of Ovarian Granulosa Cells by Upregulating Flotillin 2.
Zhou L, Han X, Li W, Wang N, Yao L, Zhao Y, Zhang L. | 05/7/2022 |
| MicroRNA-486-3p promotes the proliferation and metastasis of cutaneous squamous cell carcinoma by suppressing flotillin-2. | MicroRNA-486-3p promotes the proliferation and metastasis of cutaneous squamous cell carcinoma by suppressing flotillin-2.
Li X, Yuan Y, Wang Y, Xie K, Lu S, Chen F, Zhou M, Zhen P. | 03/12/2022 |
| Anaplasma phagocytophilum Hijacks Flotillin and NPC1 Complex To Acquire Intracellular Cholesterol for Proliferation, Which Can Be Inhibited with Ezetimibe. | Anaplasma phagocytophilum Hijacks Flotillin and NPC1 Complex To Acquire Intracellular Cholesterol for Proliferation, Which Can Be Inhibited with Ezetimibe.
Huang W, Xiong Q, Lin M, Rikihisa Y., Free PMC Article | 02/12/2022 |
| FLOT2 upregulation promotes growth and invasion by interacting and stabilizing EphA2 in gliomas. | FLOT2 upregulation promotes growth and invasion by interacting and stabilizing EphA2 in gliomas.
Song T, Hu Z, Liu J, Huang W. | 09/11/2021 |
| Flotillin-2 promotes cell proliferation via activating the c-Myc/BCAT1 axis by suppressing miR-33b-5p in nasopharyngeal carcinoma. | Flotillin-2 promotes cell proliferation via activating the c-Myc/BCAT1 axis by suppressing miR-33b-5p in nasopharyngeal carcinoma.
Liu R, Liu J, Wu P, Yi H, Zhang B, Huang W., Free PMC Article | 07/24/2021 |
| Long non-coding RNA MIR4435-2HG recruits miR-802 from FLOT2 to promote melanoma progression. | Long non-coding RNA MIR4435-2HG recruits miR-802 from FLOT2 to promote melanoma progression.
Ma DM, Sun D, Wang J, Jin DH, Li Y, Han YE. | 03/20/2021 |
| analysis of how flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis | Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis.
Fan W, Guo J, Gao B, Zhang W, Ling L, Xu T, Pan C, Li L, Chen S, Wang H, Zhang J, Wang X. | 07/11/2020 |
| miR-34c-5p can inhibit the proliferation, migration and invasion of osteosarcoma cells | The study of mechanism of miR-34c-5p targeting FLOT2 to regulate proliferation, migration and invasion of osteosarcoma cells.
Wang Y, Wang X, Tang J, Su X, Miao Y. | 01/18/2020 |
| the presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported. | Flotillins in the intercalated disc are potential modulators of cardiac excitability.
Kessler EL, van Stuijvenberg L, van Bavel JJA, van Bennekom J, Zwartsen A, Rivaud MR, Vink A, Efimov IR, Postma AV, van Tintelen JP, Remme CA, Vos MA, Banning A, de Boer TP, Tikkanen R, van Veen TAB. | 01/11/2020 |
| In invasive cells, MT1-MMP endocytosis to the endolysosomal reservoir compartment requires flotillin 1 and flotillin 2. | MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins.
Planchon D, Rios Morris E, Genest M, Comunale F, Vacher S, Bièche I, Denisov EV, Tashireva LA, Perelmuter VM, Linder S, Chavrier P, Bodin S, Gauthier-Rouvière C. | 12/7/2019 |
| It has been concluded that miR-485-5p, as a tumor suppressor, inhibits the growth and metastasis in small cell lung cancer cells by targeting FLOT2. | MicroRNA-485-5p suppresses the proliferation, migration and invasion of small cell lung cancer cells by targeting flotillin-2.
Gao F, Wu H, Wang R, Guo Y, Zhang Z, Wang T, Zhang G, Liu C, Liu J., Free PMC Article | 08/24/2019 |
| Together, the data revealed that FLOT1 and FLOT2 are crucial for Anaplasma replication in host cells, likely by aiding vesicular traffic of low-density lipoprotein-derived free cholesterol to Anaplasma inclusions. | Infection by Anaplasma phagocytophilum Requires Recruitment of Low-Density Lipoprotein Cholesterol by Flotillins.
Xiong Q, Lin M, Huang W, Rikihisa Y., Free PMC Article | 05/18/2019 |
| Results showed that flotillin-1 and flotillin-2 expression were upregulated in HCCLM3 cells following 45 degrees C heat treatment and in residual HCCLM3 xenografts cells after insufficient RFA. | Insufficient radiofrequency ablation promotes the metastasis of residual hepatocellular carcinoma cells via upregulating flotillin proteins.
Zhang N, Li H, Qin C, Ma D, Zhao Y, Zhu W, Wang L., Free PMC Article | 04/20/2019 |
| miR-133 involves in lung adenocarcinoma cell metastasis by targeting FLOT2 | miR-133 involves in lung adenocarcinoma cell metastasis by targeting FLOT2.
Wei G, Xu Y, Peng T, Yan J. | 08/18/2018 |
| Results provide evidence that Flot2 plays an important role in the progression of nasopharyngeal carcinoma cells, which may be partially related to its interaction with PLCD3. | PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells.
Liu W, Liu X, Wang L, Zhu B, Zhang C, Jia W, Zhu H, Liu X, Zhong M, Xie D, Liu Y, Li S, Shi J, Lin J, Xia X, Jiang X, Ren C., Free PMC Article | 07/21/2018 |
| Flot-2 protein expression was significantly elevated in cancerous tissues and Flot-2 played pivotal roles in the development and progression of cancers. Increased expression of Flot-2 was correlated to a poor prognosis in cancer patients. Review. | Up-regulation of Flot-2 protein is related to lymph node metastasis and poor prognosis in human solid tumors.
Liu FT, Qu QG, Zhu ZM. | 01/6/2018 |
| We demonstrated that LXR stimulation decreases mRNA and protein expression of FLOT2 and DHHC5 in MCF-7 cells. LXR stimulation also reduces Akt phosphorylation and its localization at the plasma membrane | LXR Activation Down-regulates Lipid Raft Markers FLOT2 and DHHC5 in MCF-7 Breast Cancer Cells.
Carbonnelle D, Luu TH, Chaillou C, Huvelin JM, Bard JM, Nazih H. | 08/12/2017 |
| Ectopic Flot2 could significantly reverse miR-485-mediated inhibition of metastasis and EMT, demonstrating Flot2 downregulation is involved in function of miR-485 | MiR-485 inhibits metastasis and EMT of lung adenocarcinoma by targeting Flot2.
Mou X, Liu S. | 06/3/2017 |
| Western blot experiments designed to detect flotillin 2, TMEM256, Rab3B and LAMTOR1 showed that the level of these proteins was higher in urinary exosomes from prostate cancer patients compared to healthy males, and ELISA-based detection of flotillin 2 and PARK7 showed that the combination of these proteins was able to distinguish prostate cancer patients and healthy controls with 68% sensitivity and 93% specificity | Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation.
Wang L, Skotland T, Berge V, Sandvig K, Llorente A. | 05/13/2017 |
| This study presents the endocytic pathways of internalization for muscarinic type 3 receptor and flotillin-1/2 in salivary gland epithelial cells. knockdown of flot-1 or -2 by flotillin-specific siRNA prevented internalization and reduced the endocytic efficiency of muscarinic type 3 receptor. | Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells.
Park MY, Kim N, Wu LL, Yu GY, Park K. | 05/13/2017 |