| UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis. | UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis.
Geng T, Yang D, Lin T, Cahoon JG, Wang P., Free PMC Article | 03/3/2023 |
| Role of ubiquitin regulatory X domaincontaining protein 3B in the development of hepatocellular carcinoma (Review). | Role of ubiquitin regulatory X domain‑containing protein 3B in the development of hepatocellular carcinoma (Review).
Guo Z, Liang J., Free PMC Article | 02/22/2023 |
| Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner. | Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
Gwon Y, Maxwell BA, Kolaitis RM, Zhang P, Kim HJ, Taylor JP., Free PMC Article | 11/22/2021 |
| We present physiological evidence that UBXN3B positively regulates stimulator-of-interferon genes (STING) signaling. Mechanistic studies demonstrate that UBXN3B interacts with both STING and its E3 ligase TRIM56, and facilitates STING ubiquitination, dimerization, trafficking, and consequent recruitment and phosphorylation of TBK1. | UBXN3B positively regulates STING-mediated antiviral immune responses.
Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P., Free PMC Article | 12/22/2018 |
| UBXD8 is necessary for sterol-stimulated dislocation of ubiquitylated HMGCR from the endoplasmic reticulum membrane en route to proteasomal degradation, a function dependent on its UBX domain. | Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.
Loregger A, Raaben M, Tan J, Scheij S, Moeton M, van den Berg M, Gelberg-Etel H, Stickel E, Roitelman J, Brummelkamp T, Zelcer N., Free PMC Article | 11/11/2017 |
| that newly synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis | Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains.
Schrul B, Kopito RR., Free PMC Article | 06/10/2017 |
| role of UBXD8 in cellular responses to excess fatty acids | Cellular responses to excess fatty acids: focus on ubiquitin regulatory X domain-containing protein 8.
Kim H, Ye J. | 11/8/2014 |
| the UAS domain of Ubxd8 mediates it's polymerization upon interaction with long-chain unsaturated fatty acids | UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids.
Kim H, Zhang H, Meng D, Russell G, Lee JN, Ye J., Free PMC Article | 03/1/2014 |
| UBXD8-mediated recruitment of p97/VCP to LDs increases lipid droplet (LD) size by inhibiting the activity of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis. | Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.
Olzmann JA, Richter CM, Kopito RR., Free PMC Article | 03/23/2013 |
| Ubx2 and Ubxd8 regulates lipid droplet homeostasis. | The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis.
Wang CW, Lee SC. | 01/26/2013 |
| These results indicate that ApoB after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 are engaged in the predislocation and postdislocation steps, respectively. | Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets.
Suzuki M, Otsuka T, Ohsaki Y, Cheng J, Taniguchi T, Hashimoto H, Taniguchi H, Fujimoto T., Free PMC Article | 07/28/2012 |
| These results suggest that Ubxd8 acts as a brake that limits triglyceride synthesis, and this brake is released when its structure is altered by exposure to unsaturated fatty acids. | Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis.
Lee JN, Kim H, Yao H, Chen Y, Weng K, Ye J., Free PMC Article | 05/14/2011 |
| These findings provide evidence for conserved ubiquitination pathways regulating the RasGAP proteins Ira2 (in yeast) and neurofibromin (in humans). | The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.
Phan VT, Ding VW, Li F, Chalkley RJ, Burlingame A, McCormick F., Free PMC Article | 05/3/2010 |
| ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients | Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.
Imai Y, Nakada A, Hashida R, Sugita Y, Tanaka T, Tsujimoto G, Matsumoto K, Akasawa A, Saito H, Oshida T. | 01/21/2010 |