| PDZ interaction of the GABA transporter GAT1 with the syntenin-1 in Neuro-2a cells. | PDZ interaction of the GABA transporter GAT1 with the syntenin-1 in Neuro-2a cells.
Jahodova I, Baliova M, Jursky F. | 04/19/2023 |
| Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery. | Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery.
Lin Y, Yao M, Wu H, Wu F, Cao S, Ni H, Dong J, Yang D, Sun Y, Kou X, Li J, Xiao H, Chang L, Wu J, Liu Y, Luo C, Zhu D., Free PMC Article | 07/31/2021 |
| Microglial expression of GAT-1 in the cerebral cortex. | Microglial expression of GAT-1 in the cerebral cortex.
Fattorini G, Catalano M, Melone M, Serpe C, Bassi S, Limatola C, Conti F. | 11/21/2020 |
| GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model. | GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Roberts BM, Doig NM, Brimblecombe KR, Lopes EF, Siddorn RE, Threlfell S, Connor-Robson N, Bengoa-Vergniory N, Pasternack N, Wade-Martins R, Magill PJ, Cragg SJ., Free PMC Article | 10/24/2020 |
| the expression of inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 in inferior colliculus and hippocampus astrocytes, was examined. | Expression of functional inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 by astrocytes of inferior colliculus and hippocampus.
Ghirardini E, Wadle SL, Augustin V, Becker J, Brill S, Hammerich J, Seifert G, Stephan J., Free PMC Article | 10/27/2018 |
| Results demonstrated that GAT-1-/- mice have phenotypes of hyperactivity, impaired sustained attention and learning deficiency, and the performance of GAT-1-/- mice is similar to ADHD symptoms. | Hyperactivity and impaired attention in Gamma aminobutyric acid transporter subtype 1 gene knockout mice.
Chen L, Yang X, Zhou X, Wang C, Gong X, Chen B, Chen Y. | 06/28/2016 |
| Results suggest that the excessive GAT-1 and GlyT-1/2 heterotransporter-mediated Glu release, in the spinal cord of SOD1(G93A) mice, is due to the heterotransporter over-expression at the nerve terminal membrane, promoted by the excessive Glu exocytosis | Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.
Milanese M, Bonifacino T, Fedele E, Rebosio C, Cattaneo L, Benfenati F, Usai C, Bonanno G. | 01/16/2016 |
| Results demonstrate that high-affinity activation by GABA of GAT1 transporters provokes release of [3H]GABA from nerve terminals by different mechanisms | High-affinity GABA uptake by neuronal GAT1 transporters provokes release of [(3)H]GABA by homoexchange and through GAT1-independent Ca(2+)-mediated mechanisms.
Romei C, Sabolla C, Raiteri L. | 10/10/2015 |
| these data show that during paclitaxel-induced neuropathic pain there is significant increase in GAT-1 expression in the ACC. GAT-1 is the main transporter of GABA from the synapse | Comprehensive analysis of the GABAergic system gene expression profile in the anterior cingulate cortex of mice with Paclitaxel-induced neuropathic pain.
Masocha W., Free PMC Article | 05/2/2015 |
| Development of GABA-removal system and its relationship to development of GABAergic networks studied by examination of changes in GAT-1 and GAT-3 expression and localization in embryonic and postnatal mouse spinal cord | Characteristic development of the GABA-removal system in the mouse spinal cord.
Kim J, Kosaka Y, Shimizu-Okabe C, Niizaki A, Takayama C. | 11/29/2014 |
| GAT1 plays a critical role in the regulation of rapid eye movement (REM) sleep and homeostasis of non-REM sleep. | Essential roles of GABA transporter-1 in controlling rapid eye movement sleep and in increased slow wave activity after sleep deprivation.
Xu XH, Qu WM, Bian MJ, Huang F, Fei J, Urade Y, Huang ZL., Free PMC Article | 06/21/2014 |
| results suggest that GAT1 ko mouse is a new animal model for ADHD studying and GAT1 may be a new target to treat ADHD | Gamma aminobutyric acid transporter subtype 1 gene knockout mice: a new model for attention deficit/hyperactivity disorder.
Yang P, Cai G, Cai Y, Fei J, Liu G. | 01/18/2014 |
| We failed to provide proof-of-concept evidence that lower PV and GAT1 expression in schizophrenia are a consequence of lower GAD67 expression | Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia.
Curley AA, Eggan SM, Lazarus MS, Huang ZJ, Volk DW, Lewis DA., Free PMC Article | 06/1/2013 |
| Results suggest that a moderate reduction in GAT1 activity causes the enhancement of learning and memory in mice. | Enhanced learning and memory in GAT1 heterozygous mice.
Shi J, Cai Y, Liu G, Gong N, Liu Z, Xu T, Wang Z, Fei J. | 08/18/2012 |
| We used immunohistochemistry to analyze the spatiotemporal patterns of GABA and GABA Transporter-1 (GAT1) immunoreactivities in the developing and adult mouse amygdala | Patterns of GABA and GABA Transporter-1 immunoreactivities in the developing and adult mouse brain amygdala.
Avila MA, Real MA, Guirado S. | 08/13/2011 |
| the terminal sialic acid of N-linked oligosaccharides of GAT1 plays a crucial role in the gamma aminobutyric acid transport process | Involvement of sialic acid in the regulation of γ--aminobutyric acid uptake activity of γ-aminobutyric acid transporter 1.
Hu J, Fei J, Reutter W, Fan H. | 07/2/2011 |
| GABA Transporter Mutagenesis Database (GATMD), a web-accessible, relational database of manually annotated biochemical, functional and pharmacological data reported on GAT1. | GATMD: γ-aminobutyric acid transporter mutagenesis database.
Anderson CM, Kidd PD, Eskandari S., Free PMC Article | 03/12/2011 |
| abnormal expression of GAT1 could result in spermiogenesis function injury, sperm paramorphia and dysgenesis. | Expression of GAT1 in male reproductive system and its effects on reproduction in mice.
Zhang J, Gui Y, Yuan T, Bian C, Guo L. | 03/1/2010 |
| GAT1 deletion reduces the frequency of hippocampal theta oscillation in vivo; behavioral studies show that GAT1 knock-out mice exhibit impaired hippocampus-dependent learning and memory. | GABA transporter-1 activity modulates hippocampal theta oscillation and theta burst stimulation-induced long-term potentiation.
Gong N, Li Y, Cai GQ, Niu RF, Fang Q, Wu K, Chen Z, Lin LN, Xu L, Fei J, Xu TL., Free PMC Article | 02/1/2010 |
| The gamma-aminobutyric acid transporter 1 protomer exists in membranes as dimers and higher order oligomers. Important C-terminal motifs are critical in oligomer assembly and trafficking. | GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET.
Moss FJ, Imoukhuede PI, Scott K, Hu J, Jankowsky JL, Quick MW, Lester HA., Free PMC Article | 01/13/2010 |
| GAT-1 expression on T lymphocytes is modulated by protein kinase C activation; GAT-1 deficiency induces more vigorous cell cycle entry and less cell apoptosis in T cells, thus leading to enhanced cell proliferation. | Gamma-aminobutyric acid transporter 1 negatively regulates T cell activation and survival through protein kinase C-dependent signaling pathways.
Wang Y, Luo Q, Xu Y, Feng D, Fei J, Cheng Q, Xu L. | 01/21/2010 |
| Actin confines GAT1 to the plasma membrane via ezrin, and this interaction is mediated through the PDZ-interacting domain of GAT1. | Ezrin mediates tethering of the gamma-aminobutyric acid transporter GAT1 to actin filaments via a C-terminal PDZ-interacting domain.
Imoukhuede PI, Moss FJ, Michael DJ, Chow RH, Lester HA., Free PMC Article | 01/21/2010 |
| In the developing murine postnatal neostriatum GAT-1 operates in a net uptake mode. It prevents the persistent activation of presynaptic GABA(B)Rs (P12-34) and prevents (P7-14) or reduces (P19-34) tonic postsynaptic GABA(A)R activity. | GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum.
Kirmse K, Dvorzhak A, Kirischuk S, Grantyn R., Free PMC Article | 01/21/2010 |
| GAT-1 is a critical modulator in T cell-mediated immune responses and in the pathogenesis of experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis. | Gamma-aminobutyric acid transporter 1 negatively regulates T cell-mediated immune responses and ameliorates autoimmune inflammation in the CNS.
Wang Y, Feng D, Liu G, Luo Q, Xu Y, Lin S, Fei J, Xu L. | 01/21/2010 |
| These findings demonstrate that GABA uptake and release via GAT-1, GAT-3, and VGAT are initially established in the inner retina during the first postnatal week and that these systems then mature in the outer retina during the second postnatal week. | Plasmalemmal and vesicular gamma-aminobutyric acid transporter expression in the developing mouse retina.
Guo C, Stella SL Jr, Hirano AA, Brecha NC., Free PMC Article | 01/21/2010 |