| Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase Acts as a Tumor Suppressor in Oral Squamous Cell Carcinoma. | Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase Acts as a Tumor Suppressor in Oral Squamous Cell Carcinoma.
Etemad-Moghadam S, Mohammadpour H, Emami Razavi A, Alaeddini M. | 05/29/2024 |
| PHLPP1 inhibits the growth and aerobic glycolysis activity of human ovarian granular cells through inactivating AKT pathway. | PHLPP1 inhibits the growth and aerobic glycolysis activity of human ovarian granular cells through inactivating AKT pathway.
Yang X, A M, Gegen T, Daoerji B, Zheng Y, Wang A., Free PMC Article | 01/10/2024 |
| NAP1L5 facilitates pancreatic ductal adenocarcinoma progression via TRIM29-mediated ubiquitination of PHLPP1. | NAP1L5 facilitates pancreatic ductal adenocarcinoma progression via TRIM29-mediated ubiquitination of PHLPP1.
Xiao B, Ge Y, Zhao R, Zhang Y, Guo Y, Zhang S, Li B, Qiu P, Chao Z, Zuo S. | 11/14/2023 |
| SKP2 Contributes to AKT Activation by Ubiquitination Degradation of PHLPP1, Impedes Autophagy, and Facilitates the Survival of Thyroid Carcinoma. | SKP2 Contributes to AKT Activation by Ubiquitination Degradation of PHLPP1, Impedes Autophagy, and Facilitates the Survival of Thyroid Carcinoma.
Shao Y, Ren W, Dai H, Yang F, Li X, Zhang S, Liu J, Yao X, Zhao Q, Sun X, Zheng Z, Xu C., Free PMC Article | 06/9/2023 |
| PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble. | PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble.
Sharma M, Dey CS., Free PMC Article | 11/26/2022 |
| Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells in diabetes. | Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, Pal A, Awal S, Joshi A, Rafizadeh S, Madduri MK, Khazaei M, Liu H, Yuan T, He W, Gorrepati KDD, Azizi Z, Qi Q, Ye K, Oberholzer J, Maedler K, Ardestani A., Free PMC Article | 02/12/2022 |
| Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2alpha phosphorylation and chemoresistance in colon cancer. | Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer.
Guo B, Xiong X, Hasani S, Wen YA, Li AT, Martinez R, Skaggs AT, Gao T., Free PMC Article | 02/5/2022 |
| Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer. | Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer.
Chern Y, Zhang P, Ju H, Tai IT., Free PMC Article | 10/9/2021 |
| USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway. | USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway.
Wang W, Chen M, Xu H, Lv D, Zhou S, Yang H., Free PMC Article | 05/15/2021 |
| PTEN and PHLPP crosstalk in cancer cells and in TGFbeta-activated stem cells. | PTEN and PHLPP crosstalk in cancer cells and in TGFβ-activated stem cells.
Ghalali A, Ye ZW, Högberg J, Stenius U. | 02/20/2021 |
| [Down-regulation of PHLPP1 expression ameliorates high glucose-induced autophagy inhibition and apoptosis promotion of podocytes by activating PI3K/AKT/mTOR pathway]. | [Down-regulation of PHLPP1 expression ameliorates high glucose-induced autophagy inhibition and apoptosis promotion of podocytes by activating PI3K/AKT/mTOR pathway].
Cai G, Zhang J, Wang R. | 02/6/2021 |
| Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1. | Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1.
Ohwada W, Tanno M, Yano T, Ong SB, Abe K, Sato T, Kuno A, Miki T, Sugawara H, Igaki Y, Miura T. | 12/12/2020 |
| Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. | Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice.
Zhang C, Smith MP, Zhou GK, Lai A, Hoy RC, Mroz V, Torre OM, Laudier DM, Bradley EW, Westendorf JJ, Iatridis JC, Illien-Jünger S., Free PMC Article | 08/22/2020 |
| PHLPP1 provides a proofreading step that maintains the fidelity of PKC autoinhibition and reveals a prominent loss-of-function mechanism in cancer by suppressing the steady-state levels of PKC. | Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.
Baffi TR, Van AN, Zhao W, Mills GB, Newton AC., Free PMC Article | 10/19/2019 |
| miR-190 promotes hepatocellular carcinoma cell proliferation and metastasis by targeting PHLPP1. | miR-190 promotes HCC proliferation and metastasis by targeting PHLPP1.
Xiong Y, Wu S, Yu H, Wu J, Wang Y, Li H, Huang H, Zhang H. | 09/21/2019 |
| PHLPP1 functions as a metastasis suppressor through its phosphatase activity, and PHLPP1 represents a novel diagnostic and therapeutic marker for metastatic melanoma. | PHLPP1 mediates melanoma metastasis suppression through repressing AKT2 activation.
Yu Y, Dai M, Lu A, Yu E, Merlino G., Free PMC Article | 03/16/2019 |
| Data suggest a tumor suppressor role of Xist in inhibiting AKT activation via regulation of non-X-chromosome gene PHLPP1 expression. | Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression.
Huang YS, Chang CC, Lee SS, Jou YS, Shih HM., Free PMC Article | 12/30/2017 |
| Low PHLPP expression is associated with gallbladder cancer. | SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling.
Qin Y, Meng L, Fu Y, Quan Z, Ma M, Weng M, Zhang Z, Gao C, Shi X, Han K., Free PMC Article | 10/14/2017 |
| nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. | LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1α translation.
Zhou C, Huang C, Wang J, Huang H, Li J, Xie Q, Liu Y, Zhu J, Li Y, Zhang D, Zhu Q, Huang C., Free PMC Article | 09/23/2017 |
| Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41-mediated SGT1 degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 = ring finger protein 41; SGT1 = suppressor of G2 allele of SKP1) | Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1.
Gangula NR, Maddika S., Free PMC Article | 09/16/2017 |
| Studies indicate that two PHLPP isozymes, PHLPP1 and PHLPP2, were identified in a search for phosphatases that dephosphorylate Akt, and thus suppress growth factor signaling. | PHLPPing through history: a decade in the life of PHLPP phosphatases.
Grzechnik AT, Newton AC., Free PMC Article | 07/22/2017 |
| During LPS induced macrophage inflammatory response, PHLPP levels in macrophages are depleted through the inhibition of SP1 dependent transcriptional regulation. | LPS depletes PHLPP levels in macrophages through the inhibition of SP1 dependent transcriptional regulation.
Alamuru-Yellapragada NP, Vundyala S, Behera S, Parsa KV. | 06/10/2017 |
| results identify a novel role of PHLPP in regulating aPKC and cell polarity. | Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.
Xiong X, Li X, Wen YA, Gao T., Free PMC Article | 05/27/2017 |
| Abnormal PHLPP, FoxO3a, and RAD51 protein expressions may be involved in the development of high- and low-grade ovarian serous adenocarcinomas, suggesting common molecular pathways. | Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma.
Zhang J, Wang JC, Li YH, Wang RX, Fan XM., Free PMC Article | 03/25/2017 |
| this study shows that PHLPP1 played a suppression role in inflammatory response of glioma | Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression.
Teng DC, Sun J, An YQ, Hu ZH, Liu P, Ma YC, Han B, Shi Y. | 12/31/2016 |