| Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis. | Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis.
Zhang P, Frederick MI, Heinemann IU., Free PMC Article | 12/31/2022 |
| TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance. | TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
Yang A, Bofill-De Ros X, Stanton R, Shao TJ, Villanueva P, Gu S., Free PMC Article | 09/17/2022 |
| RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type. | RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.
Medhi R, Price J, Furlan G, Gorges B, Sapetschnig A, Miska EA., Free PMC Article | 03/5/2022 |
| Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11. | Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11.
Gaza A, Fritz V, Malek L, Wormser L, Treiber N, Danner J, Kremer AE, Thasler WE, Siebler J, Meister G, Neurath MF, Hellerbrand C, Bosserhoff AK, Dietrich P., Free PMC Article | 01/1/2022 |
| This tail-U-mediated repression (TUMR) is abolished in cells lacking the uridylation enzymes TUT4 and TUT7, indicating that uridylation alters miRNA function by modulating target recognition. We identified a set of non-canonical targets in human cells that are specifically regulated by uridylated miR-27a. | 3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.
Yang A, Bofill-De Ros X, Shao TJ, Jiang M, Li K, Villanueva P, Dai L, Gu S., Free PMC Article | 01/18/2020 |
| Uridylation by TUT4, which is enriched in cytoplasmic foci, destabilizes LINE-1 mRNAs. | Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.
Warkocki Z, Krawczyk PS, Adamska D, Bijata K, Garcia-Perez JL, Dziembowski A., Free PMC Article | 05/25/2019 |
| The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU). | Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Faehnle CR, Walleshauser J, Joshua-Tor L., Free PMC Article | 08/19/2017 |
| For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s | Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.
Qian F, Feng Y, Zheng Y, Ogundiran TO, Ojengbede O, Zheng W, Blot W, Ambrosone CB, John EM, Bernstein L, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Nathanson KL, Hennis A, Nemesure B, Ambs S, Kolonel LN, Olopade OI, Haiman CA, Huo D., Free PMC Article | 05/20/2017 |
| Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase) Zcchc11 (TUT4) activity. | Identification of small molecule inhibitors of Zcchc11 TUTase activity.
Lin S, Gregory RI., Free PMC Article | 06/4/2016 |
| Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway. | Uridylation by TUT4 and TUT7 marks mRNA for degradation.
Lim J, Ha M, Chang H, Kwon SC, Simanshu DK, Patel DJ, Kim VN., Free PMC Article | 02/14/2015 |
| miR-26a directly targets Lin28B and Zcchc11-two critical repressors of let-7 maturation. | miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis.
Fu X, Meng Z, Liang W, Tian Y, Wang X, Han W, Lou G, Wang X, Lou F, Yen Y, Yu H, Jove R, Huang W., Free PMC Article | 10/18/2014 |
| Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway. | Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.
Heo I, Ha M, Lim J, Yoon MJ, Park JE, Kwon SC, Chang H, Kim VN. | 01/12/2013 |
| Lin28 uses two different TUTases to control let-7 expression . | Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).
Thornton JE, Chang HM, Piskounova E, Gregory RI., Free PMC Article | 12/8/2012 |
| Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity | Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity.
Blahna MT, Jones MR, Quinton LJ, Matsuura KY, Mizgerd JP., Free PMC Article | 02/25/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| This study uncovers the role of TUT4 and Lin28 as specific suppressors of microRNA biogenesis, which has implications for stem cell research and cancer biology. | TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.
Heo I, Joo C, Kim YK, Ha M, Yoon MJ, Cho J, Yeom KH, Han J, Kim VN, Heo I, Joo C, Kim YK, Ha M, Yoon MJ, Cho J, Yeom KH, Han J, Kim VN. | 07/28/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| TUT4 adds an oligouridine tail to the pre-let-7, which blocks Dicer processing. Knockdown of TUT4 and Lin28 reduces the level of stem cell markers | TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.
Heo I, Joo C, Kim YK, Ha M, Yoon MJ, Cho J, Yeom KH, Han J, Kim VN, Heo I, Joo C, Kim YK, Ha M, Yoon MJ, Cho J, Yeom KH, Han J, Kim VN. | 12/2/2009 |
| Zcchc11 fine tunes IL-6 production by uridylating miR-26a. | Zcchc11-dependent uridylation of microRNA directs cytokine expression.
Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP., Free PMC Article | 01/21/2010 |
| We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB. | A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.
Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A. | 01/21/2010 |