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    TRIM2 tripartite motif containing 2 [ Homo sapiens (human) ]

    Gene ID: 23321, updated on 6-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.

    Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.
    Lv R, Lu F, Xu S.

    05/30/2023
    Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.

    Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
    Esposito D, Dudley-Fraser J, Garza-Garcia A, Rittinger K., Free PMC Article

    12/24/2022
    Expression and Role of TRIM2 in Human Diseases.

    Expression and Role of TRIM2 in Human Diseases.
    Xiao M, Li J, Liu Q, He X, Yang Z, Wang D., Free PMC Article

    09/10/2022
    Knockdown of long noncoding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA3693p/TRIM2 axis.

    Knockdown of long non‑coding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA‑369‑3p/TRIM2 axis.
    Yi H, Luo D, Xiao Y, Jiang D., Free PMC Article

    11/13/2021
    Long non-coding RNA NR2F1-AS1 promoted neuroblastoma progression through miR-493-5p/TRIM2 axis.

    Long non-coding RNA NR2F1-AS1 promoted neuroblastoma progression through miR-493-5p/TRIM2 axis.
    Liu L, Zhao H, He HH, Huang J, Xu YY, Li XL, Wu Y, Wang J, Zhu YB.

    07/3/2021
    Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.

    Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
    Sun Q, Ye Z, Qin Y, Fan G, Ji S, Zhuo Q, Xu W, Liu W, Hu Q, Liu M, Zhang Z, Xu X, Yu X.

    12/19/2020
    TRIM2 expression was significantly higher in colorectal cancer tissues than in non-cancerous tissues and was significantly associated with some clinicopathological factors. The results indicate that TRIM2 is a novel promoter of human colorectal cancer.

    TRIM2 is a novel promoter of human colorectal cancer.
    Cao H, Fang Y, Liang Q, Wang J, Luo B, Zeng G, Zhang T, Jing X, Wang X.

    03/14/2020
    TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.

    TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.
    Sarute N, Ibrahim N, Medegan Fagla B, Lavanya M, Cuevas C, Stavrou S, Otkiran-Clare G, Tyynismaa H, Henao-Mejia J, Ross SR., Free PMC Article

    11/30/2019
    Study revealed that TRIM2 performs important functions in regulating the development and metastasis of osteosarcoma.

    TRIM2 regulates the development and metastasis of tumorous cells of osteosarcoma.
    Qin Y, Ye J, Zhao F, Hu S, Wang S.

    12/22/2018
    TRIM2 is associated with clinical fibrotic phenotypes of eosinophilic esophagitis.

    Gene expression-phenotype associations in adults with eosinophilic esophagitis.
    Dellon ES, Selitsky SR, Genta RM, Lash RH, Parker JS., Free PMC Article

    11/17/2018
    We found that CREBRF and TRIM2 mRNA were significantly upregulated by rHDL, particularly in response to its phospholipid component 1-palmitoyl-2-linoleoyl-phosphatidylcholine, however, protein expression was not significantly altered.

    Exploring the Roles of CREBRF and TRIM2 in the Regulation of Angiogenesis by High-Density Lipoproteins.
    Wong NKP, Cheung H, Solly EL, Vanags LZ, Ritchie W, Nicholls SJ, Ng MKC, Bursill CA, Tan JTM., Free PMC Article

    10/27/2018
    Studies indicate most-studied TRIpartite Motif (TRIM)-NHL proteins TRIM2, TRIM3, TRIM32 and TRIM71, and their mutations have been linked to diseases.

    TRIM-NHL proteins in development and disease.
    Tocchini C, Ciosk R.

    10/1/2016
    TRIM2 homozygous missense mutation (c.2000A>C; p.D667A) in a patient with peripheral neuropathy and bilateral vocal cord paralysis

    Exome sequencing reveals homozygous TRIM2 mutation in a patient with early onset CMT and bilateral vocal cord paralysis.
    Pehlivan D, Coban Akdemir Z, Karaca E, Bayram Y, Jhangiani S, Yildiz EP, Muzny D, Uluc K, Gibbs RA, Baylor-Hopkins Center for Mendelian Genomics, Elcioglu N, Lupski JR, Harel T., Free PMC Article

    07/25/2015
    The functional role of the C-terminal NHL domain was characterized in TRIM2.

    Expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal NHL domain of human TRIM2.
    Guan X, Li J, Lü X, Dong Y, Chen W, Li X., Free PMC Article

    01/31/2015
    TRIM2 is repressed by miR-9 and -181c, either alone or in combination.

    Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.
    Schonrock N, Humphreys DT, Preiss T, Götz J.

    09/15/2012
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
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