| Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production. | Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production.
Bracci N, de la Fuente C, Saleem S, Pinkham C, Narayanan A, García-Sastre A, Balaraman V, Richt JA, Wilson W, Kehn-Hall K., Free PMC Article | 02/19/2022 |
| A new 1p36.13-1p36.12 microdeletion syndrome characterized by learning disability, behavioral abnormalities, and ptosis. | A new 1p36.13-1p36.12 microdeletion syndrome characterized by learning disability, behavioral abnormalities, and ptosis.
Aagaard Nolting L, Brasch-Andersen C, Cox H, Kanani F, Parker M, Fry AE, Loddo S, Novelli A, Dentici ML, Joss S, Jørgensen JP, Fagerberg CR. | 06/5/2021 |
| UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD. | UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD.
Tang D, Sandoval W, Lam C, Haley B, Liu P, Xue D, Roy D, Patapoff T, Louie S, Snedecor B, Misaghi S., Free PMC Article | 03/20/2021 |
| The endosomal recruitment of UBR4 is essential for the biogenesis of early endosomes and endosome-related processes. | The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome.
Kim ST, Lee YJ, Tasaki T, Mun SR, Hwang J, Kang MJ, Ganipisetti S, Yi EC, Kim BY, Kwon YT. | 12/7/2019 |
| Pathogenic mutation in UBR4 gene is associated with Episodic Ataxia. | Genetic Variants Associated with Episodic Ataxia in Korea.
Choi KD, Kim JS, Kim HJ, Jung I, Jeong SH, Lee SH, Kim DU, Kim SH, Choi SY, Shin JH, Kim DS, Park KP, Kim HS, Choi JH., Free PMC Article | 07/20/2019 |
| Ubiquitin ligase Ubr4 is a key component of the podocin interactome purified from podocytes. Ubiquitylation of one podocin site, K301, do not only target podocin for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex. | The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Saez I, Schermer B, Höhne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Müller RU, Krüger M, Benzing T., Free PMC Article | 01/28/2017 |
| Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4. | KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.
Hong JH, Kaustov L, Coyaud E, Srikumar T, Wan J, Arrowsmith C, Raught B., Free PMC Article | 12/5/2015 |
| This review summarizes the central nervous system functions of p600 and proposes new perspectives on its biological complexity in neuronal physiology and neurological diseases. | p600/UBR4 in the central nervous system.
Parsons K, Nakatani Y, Nguyen MD. | 04/25/2015 |
| Although UBR4 is not an ion channel gene, the potential for disrupted Ca(2+) control within neuronal cells highlights its potential for a role in this form of episodic ataxia. | A novel locus for episodic ataxia:UBR4 the likely candidate.
Conroy J, McGettigan P, Murphy R, Webb D, Murphy SM, McCoy B, Albertyn C, McCreary D, McDonagh C, Walsh O, Lynch S, Ennis S., Free PMC Article | 11/22/2014 |
| Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling. | Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.
Morrison J, Laurent-Rolle M, Maestre AM, Rajsbaum R, Pisanelli G, Simon V, Mulder LC, Fernandez-Sesma A, García-Sastre A., Free PMC Article | 10/19/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| p600 is a cellular target of the human papillomavirus type 16 E7 oncoprotein that regulates cellular pathways that contribute to anchorage-independent growth and cellular transformation. | Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.
Huh KW, DeMasi J, Ogawa H, Nakatani Y, Howley PM, Münger K, Huh KW, DeMasi J, Ogawa H, Nakatani Y, Howley PM, Münger K., Free PMC Articles: PMC1182135, PMC1182135 | 01/21/2010 |
| Results identify and characterize p600, a unique 600-kDa retinoblastoma protein- and calmodulin-binding protein. | p600, a unique protein required for membrane morphogenesis and cell survival.
Nakatani Y, Konishi H, Vassilev A, Kurooka H, Ishiguro K, Sawada J, Ikura T, Korsmeyer SJ, Qin J, Herlitz AM., Free PMC Article | 01/21/2010 |
| Human papillomavirus E7 oncoprotein associates with p600; interaction strongly contributes to cellular transformation independent of ability of E7 to bind pRB. | Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.
Huh KW, DeMasi J, Ogawa H, Nakatani Y, Howley PM, Münger K, Huh KW, DeMasi J, Ogawa H, Nakatani Y, Howley PM, Münger K., Free PMC Articles: PMC1182135, PMC1182135 | 10/26/2005 |